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Keywords: cancer-associated mutation
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Biochem J (2010) 432 (1): 77–87.
Published: 25 October 2010
...-specific N-terminus of Fbw7α are phosphorylated in a PKC-dependent manner, both in vitro and in mammalian cells (Ser 10 and Ser 18 ). Mutational analyses reveal that phosphorylation of Fbw7α at Ser 10 can regulate its nuclear localization. Cancer-associated mutations in nearby residues (K11R...