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Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity

Maria A. Voronkova, Heather L. Hansen, Madison P. Cooper, Jacob Miller, Narayanasami Sukumar, Werner J. Geldenhuys, Aaron R. Robart, Bradley A. Webb

Biochem J (2023) 480 (17): 1411–1427.

https://doi.org/10.1042/BCJ20230207

Published: 04 September 2023

...Maria A. Voronkova; Heather L. Hansen; Madison P. Cooper; Jacob Miller; Narayanasami Sukumar; Werner J. Geldenhuys; Aaron R. Robart; Bradley A. Webb Metabolic reprogramming, including increased glucose uptake and lactic acid excretion, is a hallmark of cancer. The glycolytic ‘gatekeeper’ enzyme...

View article titled, Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity

Includes: Supplementary data

Articles

Dynamic regulation of RAS and RAS signaling

In Collection

Cell signaling in the 21st century

Walter Kolch, Dénes Berta, Edina Rosta

Biochem J (2023) 480 (1): 1–23.

https://doi.org/10.1042/BCJ20220234

Published: 06 January 2023

...Walter Kolch; Dénes Berta; Edina Rosta RAS proteins regulate most aspects of cellular physiology. They are mutated in 30% of human cancers and 4% of developmental disorders termed Rasopathies. They cycle between active GTP-bound and inactive GDP-bound states. When active, they can interact...

View article titled, Dynamic regulation of RAS and RAS signaling

Articles

CORM-3 induces DNA damage through Ru(II) binding to DNA

Rhiannon F. Lyon, Hannah M. Southam, Clare R. Trevitt, Chunyan Liao, Sherif F. El-Khamisy, Robert K. Poole, Mike P. Williamson

Biochem J (2022) 479 (13): 1429–1439.

https://doi.org/10.1042/BCJ20220254

Published: 04 July 2022

..., but not identical, because Ru(II) shows no evidence of forming intramolecular crossbridges in the DNA. The reaction is slow, and with excess Ru, intermolecular DNA crossbridges are formed. The addition of CORM-3 to human colorectal cancer cells leads to strand breaks in the DNA, as assessed by the alkaline comet...

View article titled, CORM-3 induces DNA damage through Ru(II) binding to DNA

Articles

Distinct interactors define the p63 transcriptional signature in epithelial development or cancer

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Cell death and survival

Rosalba Pecorari, Francesca Bernassola, Gerry Melino, Eleonora Candi

Biochem J (2022) 479 (12): 1375–1392.

https://doi.org/10.1042/BCJ20210737

Published: 24 June 2022

..., self-renewal capacity of epithelial stem cells, proliferation/expansion of basal keratinocytes, differentiation of stratified epithelia. In cancer, ΔNp63 is implicated in squamous cancers pathogenesis of different origin including skin, head and neck and lung and in sustaining self-renewal of cancer...

View article titled, Distinct interactors define the p63 transcriptional signature in epithelial development or cancer

Articles

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Emily C. Matchett, Elise C. Ambrose, Jacki Kornbluth

Biochem J (2022) 479 (11): 1149–1164.

https://doi.org/10.1042/BCJ20210770

Published: 08 June 2022

... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . cancer metastasis natural killer nucleoside kinase uridine kinase Uridine-cytidine kinase (UCK) is a pyrimidine ribonucleoside kinase that catalyzes...

View article titled, Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Articles

The complex interplay between autophagy and cell death pathways

In Collection

Cell death and survival

Christina Ploumi, Margarita-Elena Papandreou, Nektarios Tavernarakis

Biochem J (2022) 479 (1): 75–90.

https://doi.org/10.1042/BCJ20210450

Published: 14 January 2022

... autophagic cell death autophagy cancer necroptosis neurodegeneration Cellular recycling is essential for both survival and organismal homeostasis. These clearance mechanisms bidirectionally interact with cell death pathways either to prevent them or to promote cell destruction due to extensive...

View article titled, The complex interplay between autophagy and cell death pathways

Articles

Meiosis initiation: a story of two sexes in all creatures great and small

Ieng Fong Sou, Rebecca M. Pryce, Wee-Wei Tee, Urszula Lucja McClurg

Biochem J (2021) 478 (20): 3791–3805.

https://doi.org/10.1042/BCJ20210412

Published: 28 October 2021

... explain the frequent re-expression of normally silent meiotic genes in a variety of human cancers. cancer cancer testis antigen meiosis meiosis initiation model organisms TEX12 Ultimately, the decision to enter into meiosis is vital for the creation of variance within species. therefore...

View article titled, Meiosis initiation: a story of two sexes in all creatures great and small

Articles

Anti-glycan antibodies: roles in human disease

J. Sebastian Temme, Dorothy L. Butler, Jeffrey C. Gildersleeve

Biochem J (2021) 478 (8): 1485–1509.

https://doi.org/10.1042/BCJ20200610

Published: 21 April 2021

... Press Limited on behalf of the Biochemical Society 2021 antibodies antigens autoimmunity cancer glycobiology Antibodies, immunoglobulin proteins produced by B cells, are a critical component of the immune system. The primary function of an antibody is to bind a target molecule...

View article titled, Anti-glycan antibodies: roles in human disease

Articles

Reprogramming the tumor metastasis cascade by targeting galectin-driven networks

Ramiro M. Perrotta, Camila A. Bach, Mariana Salatino, Gabriel A. Rabinovich

Biochem J (2021) 478 (3): 597–617.

https://doi.org/10.1042/BCJ20200167

Published: 12 February 2021

... ) or ( gabriel.r@ibyme.conicet.gov.ar ) 29 11 2020 28 12 2020 21 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cancer galectins lectins metastasis tumor immunity Along with the improvement of surgical techniques...

View article titled, Reprogramming the tumor metastasis cascade by targeting galectin-driven networks

Articles

Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids

Giulia Pinto, Inés Saenz-de-Santa-Maria, Patricia Chastagner, Emeline Perthame, Caroline Delmas, Christine Toulas, Elizabeth Moyal-Jonathan-Cohen, Christel Brou, Chiara Zurzolo

Biochem J (2021) 478 (1): 21–39.

https://doi.org/10.1042/BCJ20200710

Published: 08 January 2021

...Giulia Pinto; Inés Saenz-de-Santa-Maria; Patricia Chastagner; Emeline Perthame; Caroline Delmas; Christine Toulas; Elizabeth Moyal-Jonathan-Cohen; Christel Brou; Chiara Zurzolo Glioblastoma (GBM) is the most aggressive brain cancer and its relapse after surgery, chemo and radiotherapy appears...

View article titled, Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids

Includes: Multimedia, Supplementary data

Articles

Impairing activation of phospholipid synthesis by c-Fos interferes with glioblastoma cell proliferation

César G. Prucca, Ana C. Racca, Fabiola N. Velazquez, Andrés M. Cardozo Gizzi, Lucia Rodríguez Berdini, Beatriz L. Caputto

Biochem J (2020) 477 (23): 4675–4688.

https://doi.org/10.1042/BCJ20200465

Published: 11 December 2020

.... † Current Address: Stony Brook Cancer Center and the Department of Medicine, Stony Brook University, Stony Brook, U.S.A. 15 6 2020 11 11 2020 19 11 2020 19 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 c-fos...

View article titled, Impairing activation of phospholipid synthesis by c-Fos interferes with glioblastoma cell proliferation

Includes: Supplementary data

Articles

Exploiting S- nitrosylation for cancer therapy: facts and perspectives

Salvatore Rizza, Giuseppe Filomeni

Biochem J (2020) 477 (19): 3649–3672.

https://doi.org/10.1042/BCJ20200064

Published: 05 October 2020

... found in pathological states. In the last few years, a role in cancer has been proposed, supported by the evidence that various oncoproteins undergo gain- or loss-of-function modifications upon S -nitrosylation. Here, we aim at providing insight into the current knowledge about the role of S...

View article titled, Exploiting S- nitrosylation for cancer therapy: facts and perspectives

Articles

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity

Lucas A. Luna, Zachary Lesecq, Katharine A. White, An Hoang, David A. Scott, Olga Zagnitko, Andrey A. Bobkov, Diane L. Barber, Jamie M. Schiffer, Daniel G. Isom, Christal D. Sohl

Biochem J (2020) 477 (16): 2999–3018.

https://doi.org/10.1042/BCJ20200311

Published: 21 August 2020

... to question whether IDH1 catalysis is pH-regulated, which would have functional implications under conditions that alter cellular pH, like apoptosis, hypoxia, cancer, and neurodegenerative diseases. Here, we show evidence of catalytic regulation of IDH1 by pH, identifying a trend of increasing k cat values...

View article titled, An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity

Includes: Supplementary data

Articles

RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics

Walaa E. Kattan, John F. Hancock

Biochem J (2020) 477 (15): 2893–2919.

https://doi.org/10.1042/BCJ20190839

Published: 14 August 2020

...Walaa E. Kattan; John F. Hancock The three human RAS proteins are mutated and constitutively activated in ∼20% of cancers leading to cell growth and proliferation. For the past three decades, many attempts have been made to inhibit these proteins with little success. Recently; however, multiple...

View article titled, RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics

Articles

The molecular functions of RIT1 and its contribution to human disease

Richard Van, Antonio Cuevas-Navarro, Pau Castel, Frank McCormick

Biochem J (2020) 477 (15): 2755–2770.

https://doi.org/10.1042/BCJ20200442

Published: 07 August 2020

... and mutations in these are pathogenic in cancer and a class of developmental disorders termed RASopathies. Emerging clinical evidences have now demonstrated a role for RIT1 in RASopathies, namely Noonan syndrome, and various cancers including lung adenocarcinoma and myeloid malignancies. While RIT1 has been...

View article titled, The molecular functions of RIT1 and its contribution to human disease

Articles

Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging

Susana Castro-Obregón

Biochem J (2020) 477 (14): 2715–2720.

https://doi.org/10.1042/BCJ20200165

Published: 29 July 2020

.... showed that when DNA is damaged by ɣ-radiation in cancer cells, LBR is lost causing chromatin structure changes and promoting cellular senescence. Cellular senescence is characterized by terminal cell cycle arrest and the expression and secretion of various growth factors, cytokines, metalloproteinases...

View article titled, Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging

Articles

Cell-penetrating peptides: two faces of the same coin

Giovanna Maria Pierantoni, Simona Paladino

Biochem J (2020) 477 (8): 1363–1366.

https://doi.org/10.1042/BCJ20200006

Published: 23 April 2020

... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer cell penetrating peptide lipid microdomains membranes therapeutics trafficking In a recent issue of this journal Eissa et al. highlight a novel membrane-active...

View article titled, Cell-penetrating peptides: two faces of the same coin

Articles

Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity

Sunil Singh, J. Sivaraman

Biochem J (2020) 477 (5): 905–923.

https://doi.org/10.1042/BCJ20200027

Published: 04 March 2020

...’ subfamily HECT and influences several crucial cellular processes, including innate immunity, proteasome processivity, and cancer metastasis. Here, we report the crystal structure of the HECT domain of UBE3C (amino acids (aa) 744–1083) with an additional fifty N-terminal amino acids (aa 693–743) at 2.7...

View article titled, Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity

Includes: Supplementary data

Articles

Biophysical characterization of p53 core domain aggregates

Igor Lima, Ambuja Navalkar, Samir K. Maji, Jerson L. Silva, Guilherme A.P. de Oliveira, Elio A. Cino

Biochem J (2020) 477 (1): 111–120.

https://doi.org/10.1042/BCJ20190778

Published: 08 January 2020

..., such as oligomers and amyloid fibrils. p53 is an essential tumor suppressor that is prone to such conformational transitions, resulting in its compromised ability to avert cancer. This work explores the biophysical properties of early-, mid-, and late-stage p53 core domain (p53C) aggregates. Atomistic and coarse...

View article titled, Biophysical characterization of p53 core domain aggregates

Articles

BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress

Han-Sae Lee, Hye-Ran Seo, Shin-Ai Lee, Soohee Choi, Dongmin Kang, Jongbum Kwon

Biochem J (2019) 476 (20): 3053–3066.

https://doi.org/10.1042/BCJ20190622

Published: 28 October 2019

...Han-Sae Lee; Hye-Ran Seo; Shin-Ai Lee; Soohee Choi; Dongmin Kang; Jongbum Kwon The recovery from replication stress by restarting stalled forks to continue DNA synthesis is crucial for maintaining genome stability and thereby preventing diseases such as cancer. We previously showed that BRCA1...

View article titled, BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress

Includes: Supplementary data

Articles

Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies

Catherine E. Scull, Yinfeng Zhang, Nichole Tower, Lynn Rasmussen, Indira Padmalayam, Robert Hunter, Ling Zhai, Robert Bostwick, David A. Schneider

Biochem J (2019) 476 (15): 2209–2219.

https://doi.org/10.1042/BCJ20190207

Published: 09 August 2019

...Catherine E. Scull; Yinfeng Zhang; Nichole Tower; Lynn Rasmussen; Indira Padmalayam; Robert Hunter; Ling Zhai; Robert Bostwick; David A. Schneider Over the past two decades, ribosome biogenesis has emerged as an attractive target for cancer treatment. In this study, two high-throughput screens were...

View article titled, Discovery of novel inhibitors of ribosome biogenesis by innovative high throughput screening strategies

Includes: Supplementary data

Articles

Tubulin heterogeneity regulates functions and dynamics of microtubules and plays a role in the development of drug resistance in cancer

Shweta Shyam Prassanawar, Dulal Panda

Biochem J (2019) 476 (9): 1359–1376.

https://doi.org/10.1042/BCJ20190123

Published: 12 May 2019

...-translational modifications (PTMs). These heterogeneities confer differential stability to microtubules and provide spatial cues for the functioning of the cell. Furthermore, the altered expressions of tubulin isotypes and PTMs are prominent factors for the development of resistance against some cancer drugs...

View article titled, Tubulin heterogeneity regulates functions and dynamics of microtubules and plays a role in the development of drug resistance in cancer

Articles

The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

Anna M. Schmoker, Alicia M. Ebert, Bryan A. Ballif

Biochem J (2019) 476 (6): 931–950.

https://doi.org/10.1042/BCJ20190022

Published: 22 March 2019

... from structural and signaling aspects to their associations with cancer, physiology, and development. Correspondence: Anna M. Schmoker ( aschmoke@uvm.edu ) or Bryan A. Ballif ( bballif@uvm.edu ) 11 1 2019 20 2 2019 4 3 2019 © 2019 The Author(s). Published by Portland Press...

View article titled, The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease

Includes: Supplementary data

Articles

Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling

Martin A. Rossotti, Kevin A. Henry, Henk van Faassen, Jamshid Tanha, Deborah Callaghan, Greg Hussack, Mehdi Arbabi-Ghahroudi, C. Roger MacKenzie

Biochem J (2019) 476 (1): 39–50.

https://doi.org/10.1042/BCJ20180795

Published: 07 January 2019

... by Portland Press Limited on behalf of the Biochemical Society 2019 antibodies cancer DNA immunization epidermal growth factor receptor single-domain antibodies V H H The epidermal growth factor receptor ( EGFR ) is a receptor tyrosine kinase that is overexpressed and constitutively...

View article titled, Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling

Includes: Supplementary data

Articles

The multifunctional role of phospho-calmodulin in pathophysiological processes

Antonio Villalobo

Biochem J (2018) 475 (24): 4011–4023.

https://doi.org/10.1042/BCJ20180755

Published: 21 December 2018

...) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . brain hypoxia cancer cell toxicity hypertension melatonin prion encephalopathies The K...

View article titled, The multifunctional role of phospho-calmodulin in pathophysiological processes

Articles

Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity

Hitoshi Nakamoto, Yosuke Amaya, Taiwa Komatsu, Takehiro Suzuki, Naoshi Dohmae, Yusuke Nakamura, Ibrahim Jantan, Yoshihiko Miyata

Biochem J (2018) 475 (15): 2559–2576.

https://doi.org/10.1042/BCJ20180230

Published: 16 August 2018

...Hitoshi Nakamoto; Yosuke Amaya; Taiwa Komatsu; Takehiro Suzuki; Naoshi Dohmae; Yusuke Nakamura; Ibrahim Jantan; Yoshihiko Miyata Hsp90 is an ATP-dependent molecular chaperone that assists folding and conformational maturation/maintenance of many proteins. It is a potential cancer drug target...

View article titled, Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity

Includes: Supplementary data

Articles

The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Yalda Hekmatshoar, Jean Nakhle, Mireille Galloni, Marie-Luce Vignais

Biochem J (2018) 475 (14): 2305–2328.

https://doi.org/10.1042/BCJ20170712

Published: 31 July 2018

...Yalda Hekmatshoar; Jean Nakhle; Mireille Galloni; Marie-Luce Vignais Intercellular communications play a major role in tissue homeostasis. In pathologies such as cancer, cellular interactions within the tumor microenvironment (TME) contribute to tumor progression and resistance to therapy...

View article titled, The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

Articles

Therapeutic targeting of non-coding RNAs in cancer

Ondrej Slaby, Richard Laga, Ondrej Sedlacek

Biochem J (2017) 474 (24): 4219–4251.

https://doi.org/10.1042/BCJ20170079

Published: 14 December 2017

... development in cancer. Although microRNAs (miRNAs) are the most studied regulatory ncRNAs to date, and miRNA-targeted therapeutics have already reached clinical development, including the mimics of the tumour suppressive miRNAs miR-34 and miR-16, which reached phase I clinical trials for the treatment...

View article titled, Therapeutic targeting of non-coding RNAs in cancer

Articles

Dual histone reader ZMYND8 inhibits cancer cell invasion by positively regulating epithelial genes

Moitri Basu, Isha Sengupta, Md Wasim Khan, Dushyant Kumar Srivastava, Partha Chakrabarti, Siddhartha Roy, Chandrima Das

Biochem J (2017) 474 (11): 1919–1934.

https://doi.org/10.1042/BCJ20170223

Published: 19 May 2017

...Moitri Basu; Isha Sengupta; Md Wasim Khan; Dushyant Kumar Srivastava; Partha Chakrabarti; Siddhartha Roy; Chandrima Das Enhanced migratory potential and invasiveness of cancer cells contribute crucially to cancer progression. These phenotypes are achieved by precise alteration of invasion...

View article titled, Dual histone reader ZMYND8 inhibits cancer cell invasion by positively regulating epithelial genes

Includes: Supplementary data

Articles

RUNX transcription factors at the interface of stem cells and cancer

Elitza Deltcheva, Rachael Nimmo

Biochem J (2017) 474 (11): 1755–1768.

https://doi.org/10.1042/BCJ20160632

Published: 10 May 2017

... role of RUNX1. Furthermore, in solid cancers, RUNX1 is overexpressed compared with normal tissue, and RUNX factors have recently been discovered to promote growth of skin, oral, breast and ovarian tumour cells, amongst others. RUNX factors have key roles in stem cell fate regulation during homeostasis...

View article titled, RUNX transcription factors at the interface of stem cells and cancer

Articles

Systematic approaches to identify E3 ligase substrates

Mary Iconomou, Darren N. Saunders

Biochem J (2016) 473 (22): 4083–4101.

https://doi.org/10.1042/BCJ20160719

Published: 10 November 2016

... prevent binding of the E3 ligase MDM2 to its substrate, the tumour suppressor p53 [ 19 , 48 – 51 ]. Another compound currently in clinical trials for cancer is the Smac mimetic GDC-0152, which binds to anti-apoptotic proteins (IAPs), inducing IAP self-ubiquitylation and degradation, and consequently...

View article titled, Systematic approaches to identify E3 ligase substrates

Articles

Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6–7 linker

Mike R. Wilson, Zhanjun Hou, Lucas J. Wilson, Jun Ye, Larry H. Matherly

Biochem J (2016) 473 (20): 3545–3562.

https://doi.org/10.1042/BCJ20160399

Published: 11 October 2016

..., NJ). The human RFC- and hPCFT-null R1-11 HeLa cell line was a gift from Dr I. David Goldman (Albert Einstein Cancer Center, Bronx, NY) [ 36 ]. R1-11 cells were grown in RPMI 1640 medium supplemented with 10% FBS, 2 mM l -glutamine, 100 units/ml penicillin/100 µg/ml streptomycin, and 600 µg/ml...

View article titled, Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6–7 linker

Includes: Supplementary data

Articles

GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1

Matthew Velinder, Jason Singer, Diana Bareyan, Jessica Meznarich, Christopher M. Tracy, James M. Fulcher, David McClellan, Helena Lucente, Sarah Franklin, Sunil Sharma, Michael E. Engel

Biochem J (2016) 473 (19): 3355–3369.

https://doi.org/10.1042/BCJ20160558

Published: 27 September 2016

... 2016 1 8 2016 1 8 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 cancer epigenetics GFI1 LSD1 methylation transcription Growth factor independence 1 (GFI1) is a transcriptional repressor and master regulator...

View article titled, GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1

Includes: Supplementary data

Articles

Critical role of XBP1 in cancer signalling is regulated by PIN1

Unbin Chae, Sun-Ji Park, Bokyung Kim, Shou Wei, Ju-Sik Min, Jun-Hyeog Lee, Se Hoon Park, Ann-Hwee Lee, Kun Ping Lu, Dong-Seok Lee, Sang-Hyun Min

Biochem J (2016) 473 (17): 2603–2610.

https://doi.org/10.1042/BCJ20160482

Published: 30 August 2016

...Unbin Chae; Sun-Ji Park; Bokyung Kim; Shou Wei; Ju-Sik Min; Jun-Hyeog Lee; Se Hoon Park; Ann-Hwee Lee; Kun Ping Lu; Dong-Seok Lee; Sang-Hyun Min XBP1 (X-box-binding protein 1) is activated in cancer and has a pivotal role in tumorigenesis and progression of human cancer. In particular, the XBP1...

View article titled, Critical role of XBP1 in cancer signalling is regulated by PIN1

Articles

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

Kathryn M. Taylor, Issa A. Muraina, Dylan Brethour, Gerold Schmitt-Ulms, Thirayost Nimmanon, Silvia Ziliotto, Peter Kille, Christer Hogstrand

Biochem J (2016) 473 (16): 2531–2544.

https://doi.org/10.1042/BCJ20160388

Published: 11 August 2016

...Kathryn M. Taylor; Issa A. Muraina; Dylan Brethour; Gerold Schmitt-Ulms; Thirayost Nimmanon; Silvia Ziliotto; Peter Kille; Christer Hogstrand There is growing evidence that zinc and its transporters are involved in cell migration during development and in cancer. In the present study, we show...

View article titled, Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

Includes: Supplementary data

Articles

Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals

Ryuta Tobe, Bradley A. Carlson, Jang Hoe Huh, Nadia P. Castro, Xue-Ming Xu, Petra A. Tsuji, Sang-Goo Lee, Jeyoung Bang, Ji-Woon Na, Young-Yun Kong, Daniel Beaglehole, Eileen Southon, Harold Seifried, Lino Tessarollo, David S. Salomon, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee

Biochem J (2016) 473 (14): 2141–2154.

https://doi.org/10.1042/BCJ20160393

Published: 12 July 2016

... viability, but significantly affected the expression of a large number of mRNAs involved in cancer, embryonic development and the glutathione system. Particularly notable was the extreme deficiency of glutaredoxin 1 (GLRX1) and glutathione transferase Omega 1 (GSTO1). To assess these phenotypes...

View article titled, Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals

Includes: Supplementary data

Articles

Niclosamide blocks glucagon phosphorylation of Ser 552 on β-catenin in primary rat hepatocytes via PKA signalling

Md. Kamrul H. Chowdhury, Lindsay E. Wu, James L.J. Coleman, Nicola J. Smith, Margaret J. Morris, Peter R. Shepherd, Greg C. Smith

Biochem J (2016) 473 (9): 1247–1255.

https://doi.org/10.1042/BCJ20160121

Published: 26 April 2016

... glucagon signalling that leads to increased β-catenin activity that can be reversed with the antihelminthic drug niclosamide, which has recently shown promise as a potential treatment of T2D (Type 2 diabetes). This novel finding could be useful in liver cancer treatment, particularly in the context of T2D...

View article titled, Niclosamide blocks glucagon phosphorylation of Ser 552 on β-catenin in primary rat hepatocytes via PKA signalling

Articles

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

Yiguo Zhang, Yuancai Xiang

Biochem J (2016) 473 (8): 961–1000.

https://doi.org/10.1042/BJ20151182

Published: 08 April 2016

... of Nrf1 results in spontaneous development of non-alcoholic steatohepatitis, hepatoma, diabetes and neurodegenerative diseases in animal models. 1 To whom correspondence should be addressed (email yiguozhang@cqu.edu.cn , or eaglezhang64@gmail.com ). cancer diabetes homoeostasis Nrf1 Nrf2...

View article titled, Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

Articles

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

Bethany Nancolas, Lili Guo, Rong Zhou, Kavindra Nath, David S. Nelson, Dennis B. Leeper, Ian A. Blair, Jerry D. Glickson, Andrew P. Halestrap

Biochem J (2016) 473 (7): 929–936.

https://doi.org/10.1042/BJ20151120

Published: 29 March 2016

... at 13 min followed by a 4-min equilibration. bioenergetics cancer metabolism mitochondrial pyruvate carrier monocarboxylate transporter tumour acidification Lonidamine (LND), first introduced in 1979 as an anti-spermogenic agent [ 1 ], has limited antineoplastic activity as a single...

View article titled, The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

Articles

Repurposing metformin: an old drug with new tricks in its binding pockets

Rosina Pryor, Filipe Cabreiro

Biochem J (2015) 471 (3): 307–322.

https://doi.org/10.1042/BJ20150497

Published: 16 October 2015

... the diseases of old age, including type 2 diabetes (T2D), cardiovascular disease (CVD) and cancer. Developing new ways to improve health in the elderly is therefore a top priority for biomedical research. Although our understanding of the molecular basis of these morbidities has advanced rapidly, effective...

View article titled, Repurposing metformin: an old drug with new tricks in its binding pockets

Articles

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann–Pick C1

Ximing Du, Yuxi Zhang, Sae Rom Jo, Xiaoyun Liu, Yanfei Qi, Brenna Osborne, Frances L. Byrne, Greg C. Smith, Nigel Turner, Kyle L. Hoehn, Andrew J. Brown, Hongyuan Yang

Biochem J (2015) 471 (2): 243–253.

https://doi.org/10.1042/BJ20150602

Published: 02 October 2015

...)/mTOR [mammalian (or mechanistic) target of rapamycin] signalling pathway in cervical cancer cell lines. We provided evidence that activated Akt/mTOR pathway increased NPC1 degradation by ∼50% in C33A cells when compared with SiHa or HeLa cells. NPC1 degradation in C33A cells was reversed when Akt/mTOR...

View article titled, Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann–Pick C1

Includes: Supplementary data

Articles

Peroxiredoxin 6 triggers melanoma cell growth by increasing arachidonic acid-dependent lipid signalling

Alexandra Schmitt, Werner Schmitz, Anita Hufnagel, Manfred Schartl, Svenja Meierjohann

Biochem J (2015) 471 (2): 267–279.

https://doi.org/10.1042/BJ20141204

Published: 02 October 2015

... Press Limited 2015 We found that the phospholipase A 2 activity of PRDX6 is an important factor for human melanoma cell proliferation by enhancing arachidonic acid-dependent Src kinase signalling. cancer lipid signalling melanoma oxidative stress peroxiredoxin Compared...

View article titled, Peroxiredoxin 6 triggers melanoma cell growth by increasing arachidonic acid-dependent lipid signalling

Includes: Supplementary data

Articles

Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation

Marco Kloos, Antje Brüser, Jürgen Kirchberger, Torsten Schöneberg, Norbert Sträter

Biochem J (2015) 469 (3): 421–432.

https://doi.org/10.1042/BJ20150251

Published: 23 July 2015

...Marco Kloos; Antje Brüser; Jürgen Kirchberger; Torsten Schöneberg; Norbert Sträter Phosphofructokinase-1 (Pfk) acts as the main control point of flux through glycolysis. It is involved in complex allosteric regulation and Pfk mutations have been linked to cancer development. Whereas the 3D...

View article titled, Crystal structure of human platelet phosphofructokinase-1 locked in an activated conformation

Includes: Supplementary data

Articles

Analysis of the intricate relationship between chronic inflammation and cancer

Edna Zhi Pei Chai, Kodappully Sivaraman Siveen, Muthu K. Shanmugam, Frank Arfuso, Gautam Sethi

Biochem J (2015) 468 (1): 1–15.

https://doi.org/10.1042/BJ20141337

Published: 05 May 2015

... microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer...

View article titled, Analysis of the intricate relationship between chronic inflammation and cancer

Articles

Going for broke: targeting the human cancer pseudokinome

Fiona P. Bailey, Dominic P. Byrne, Daniel McSkimming, Natarajan Kannan, Patrick A. Eyers

Biochem J (2015) 465 (2): 195–211.

https://doi.org/10.1042/BJ20141060

Published: 06 January 2015

...Fiona P. Bailey; Dominic P. Byrne; Daniel McSkimming; Natarajan Kannan; Patrick A. Eyers Protein phosphorylation lies at the heart of cell signalling, and somatic mutation(s) in kinases drives and sustains a multitude of human diseases, including cancer. The human protein kinase superfamily...

View article titled, Going for broke: targeting the human cancer pseudokinome

Articles

Oncogene dependency and the potential of targeted RNAi-based anti-cancer therapy

Ruiyang Yan, Andrew Hallam, Peter G. Stockley, Joan Boyes

Biochem J (2014) 461 (1): 1–13.

https://doi.org/10.1042/BJ20140173

Published: 13 June 2014

...Ruiyang Yan; Andrew Hallam; Peter G. Stockley; Joan Boyes Cancers arise through the progression of multiple genetic and epigenetic defects that lead to deregulation of numerous signalling networks. However, the last decade has seen the development of the concept of ‘oncogene addiction’, where...

View article titled, Oncogene dependency and the potential of targeted RNAi-based anti-cancer therapy

Articles

How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine–aspartic acid (LD) motifs

Tanvir Alam, Meshari Alazmi, Xin Gao, Stefan T. Arold

Biochem J (2014) 460 (3): 317–329.

https://doi.org/10.1042/BJ20140298

Published: 29 May 2014

... and the evolution of multicellularity. LD motifs also play roles in disease, such as in cancer metastasis or viral infection. First described in the paxillin family of scaffolding proteins, LD motifs and similar acidic LXXLL interaction motifs have been discovered in several other proteins, whereas 16 proteins have...

View article titled, How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine–aspartic acid (LD) motifs

Articles

Casein kinase: the triple meaning of a misnomer

Andrea Venerando, Maria Ruzzene, Lorenzo A. Pinna

Biochem J (2014) 460 (2): 141–156.

https://doi.org/10.1042/BJ20140178

Published: 13 May 2014

...@unipd.it ). 5 2 2014 14 3 2014 18 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer casein kinase 1 (CK1) casein kinase 2 (CK2) family with sequence similarity 20C (Fam20C) genuine casein kinase (G-CK) neurodegeneration In the second...

View article titled, Casein kinase: the triple meaning of a misnomer

Includes: Supplementary data

Articles

Liver X receptor: from metabolism to cancer

Nicolas Venteclef, Pascal Ferré

Biochem J (2014) 459 (2): e1–e3.

https://doi.org/10.1042/BJ20140211

Published: 28 March 2014

... immunity by interfering with macrophage activation. Recent advances have highlighted a controversial role for LXR in cancer. In this issue of the Biochemical Journal , Wang et al. propose that LXR agonist directly controls IFN-γ (interferon-γ) expression, which limits tumour growth. This protective effect...

View article titled, Liver X receptor: from metabolism to cancer

Articles

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Simon A. Hawley, Fiona A. Ross, Graeme J. Gowans, Priyanka Tibarewal, Nicholas R. Leslie, D. Grahame Hardie

Biochem J (2014) 459 (2): 275–287.

https://doi.org/10.1042/BJ20131344

Published: 28 March 2014

... to reduced Thr 172 phosphorylation and activation by LKB1. We establish a molecular mechanism for this effect and show that it causes down-regulation of AMPK in several PTEN-null tumour cell lines. Akt AMP-activated protein kinase (AMPK) cancer cross-talk tumour suppressor AMPK (AMP...

View article titled, Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

Includes: Supplementary data

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