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Keywords: calcium
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Biochem J (2019) 476 (19): 2835–2850.
Published: 11 October 2019
...+ . Furthermore, treatment of platelets with thapsigargin or Ca 2+ ionophore robustly induced ASK1/p38 activation. In addition, calcium and integrin-binding protein 1 (CIB1), a Ca 2+ -dependent negative regulator of ASK1, associates with ASK1 in resting platelets and is dissociated upon platelet activation...
Includes: Supplementary data
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Biochem J (2018) 475 (16): 2621–2636.
Published: 29 August 2018
...Akhilesh K. Yadav; Saroj K. Jha; Sibaji K. Sanyal; Sheng Luan; Girdhar K. Pandey Calcium (Ca 2+ ) is a versatile and ubiquitous second messenger in all eukaryotes including plants. In response to various stimuli, cytosolic calcium concentration ([Ca 2+ ] cyt ) is increased, leading to activation...
Includes: Supplementary data
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Biochem J (2018) 475 (8): 1411–1425.
Published: 23 April 2018
...Abir U. Igamberdiev; Robert D. Hill Ca 2+ can be released from cell compartments to the cytosol during stress conditions. We discuss here the causes of Ca 2+ release under conditions of ATP concentration decline that result in the suppression of ATPases and activation of calcium ion channels...
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Biochem J (2018) 475 (1): 289–303.
Published: 11 January 2018
... it in an active form in Saccharomyces cerevisiae , as previously done for SMA2. Using phosphorylation assays from ATP, we demonstrated that like SMA2, SMA1 bound calcium in a cooperative mode with an apparent affinity in the micromolar range. We also showed that SMA1 and SMA2 had close sensitivities...
Includes: Supplementary data
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Biochem J (2017) 474 (8): 1321–1332.
Published: 24 March 2017
.... Correspondence: Michael J. Berridge ( michael.berridge@babraham.ac.uk ) 13 1 2017 10 2 2017 13 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 calcium diabetes Vitamin D Diabetes, which is characterized...
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Biochem J (2016) 473 (13): 1929–1940.
Published: 28 June 2016
... and metalloproteinase 10 (ADAM10) calcium cytotoxicity E-cadherin microtubule-associated protein 1A/1B light chain 3 (LC3) Staphylococcus aureus α-toxin α-Hemolysin or α-toxin, is the archetype of small β-pore-forming toxins [ 1 – 3 ] . It is a major exoproduct of Staphylococcus aureus , secreted...
Includes: Supplementary data
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Biochem J (2016) 473 (9): 1129–1140.
Published: 26 April 2016
... by factors that sensitize the MPTP to [Ca 2+ ]. We propose that GNX-4975 binds to this interface preventing a calcium-triggered event that opens the interface into a pore. adenine nucleotide translocase calcium inhibition mitochondrial permeability transition pores mitochondrial phosphate carrier...
Includes: Supplementary data
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Biochem J (2015) 472 (2): 195–204.
Published: 13 November 2015
... of cell proliferation, as its alteration could potentially result in uncontrolled tumour growth. calcium calmodulin epidermal growth factor receptor phospho-(Tyr)-calmodulin tyrosine kinase The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that belongs...
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Biochem J (2015) 471 (1): 111–122.
Published: 21 September 2015
... by substrate-dependent blockade of ATP-sensitive K + channels in insulin-secreting INS-1 832/13 are differentially linked to distinct voltage-activated Ca 2+ channels and drive exocytosis. Ca 2+ feeds back to control oscillation frequency, amplitude and prevalence. bioenergetics calcium exocytosis...
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Biochem J (2015) 467 (1): 37–46.
Published: 20 March 2015
... DiaPharma. Human and bovine prothrombin as well as active-site–labelled fXa (FEGR–fXa) and dansylarginine- N -(3-ethyl-1,5-pentanediyl)amide (DAPA) were all purchased from Hematologic Technologies. Reagent grade calcium chloride was from Fisher Chemicals was dried in an oven and desiccated before preparing...
Includes: Supplementary data
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Biochem J (2015) 466 (3): 537–546.
Published: 06 March 2015
... underlies ROS-induced β-cell death and Zn 2+ , rather than Ca 2+ , plays a primary role in apoptosis. apoptosis calcium reactive oxygen species Type 1 diabetes transient receptor potential (melastatin) 2 (TRPM2) channels zinc Human embryonic kidney (HEK)-293 and insulin secreting (INS1...
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Biochem J (2015) 465 (3): 359–370.
Published: 22 January 2015
...Claudia Nora Tomes Exocytosis is a highly regulated process that consists of multiple functionally, kinetically and/or morphologically definable stages such as recruitment, targeting, tethering and docking of secretory vesicles with the plasma membrane, priming of the fusion machinery and calcium...
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Biochem J (2015) 465 (2): 227–238.
Published: 06 January 2015
... (eukaryotic elongation factor 2 kinase). calcium cold-shock eukaryotic elongation factor 2 (eEF2) eukaryotic elongation factor 2 kinase (eEF2K) hypothermia protein synthesis The control of protein synthesis is an essential component of the response to deviation from an ambient environment...
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Biochem J (2013) 453 (1): 147–151.
Published: 13 June 2013
...://robetta.bakerlab.org/ ). calcium endosome lysosome nicotinic acid–adenine dinucleotide phosphate (NAADP) two-pore segment channel 1 (TPCN1) trafficking NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent and widespread Ca 2+ -mobilizing messenger [ 1 ]. It regulates processes...
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Biochem J (2013) 450 (2): 365–373.
Published: 15 February 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 calcium cAMP exchange protein directly activated by cAMP 1 (Epac1) exocytosis fluorescence microscopy insulin total internal reflection yellow fluorescent protein In pancreatic β-cells, glucose-stimulated insulin secretion...
Includes: Supplementary data
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Biochem J (2013) 449 (2): 449–457.
Published: 14 December 2012
...-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cameleon calcium fluorescence resonance energy transfer (FRET) lysosome sensor signalling...
Includes: Multimedia, Supplementary data
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Biochem J (2012) 448 (2): 189–200.
Published: 07 November 2012
... Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. calcium CatSper hyperactivation progesterone sperm store-operated channel Within...
Includes: Multimedia, Supplementary data
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Biochem J (2012) 444 (2): 211–218.
Published: 11 May 2012
... calcium cell invasion mucin Trypanosoma cruzi trypomastigote small surface antigen (TSSA) HEK (human embryonic kidney)-293 cells (3×10 4 ) grown in DMEM (Dulbecco's modified Eagle's medium) were seeded on black-wall clear-bottom 96-well plates (Costar). After 24 h of incubation, cells were...
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Biochem J (2012) 441 (1): 435–442.
Published: 14 December 2011
... compilation © 2012 Biochemical Society 2012 calcium cell signalling Ned-19 nicotinamide acid–adenine dinucleotide phosphate (NAADP) platelet Platelets are small anucleate cells that circulate in high numbers in the blood. Under normal physiological conditions, platelets respond to vascular...
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Biochem J (2011) 438 (3): 545–553.
Published: 26 August 2011
... and reproduction in any medium, provided the original work is properly cited. calcium Chinese-hamster ovary (CHO) cell egg oscillation phospholipase C (PLC) sperm PLCζ (phospholipase Cζ) is an isoform of phosphoinositide-specific PLC that is specifically expressed in mammalian sperm cells [ 1...
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Biochem J (2011) 435 (3): 597–608.
Published: 13 April 2011
... in the range 4–90°C following temperature-induced changes in ellipticity at 218 nm, where the temperature was increased 1°C/min, using 1.5-nm bandwidth, an averaging time of 30 s and an equilibration time of 2 min. C2 domain calcium nuclear magnetic resonance (NMR) phosphoinositide Toll-interacting...
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Biochem J (2011) 435 (3): 711–722.
Published: 13 April 2011
... 1 To whom correspondence should be addressed (email chejjy@langate.gsu.edu ). calcium calmodulin connexin50 gap junction junctional conductance protein–protein interaction (4) where D 0 , R 0 and C 0 are the diffusion constant, hydro-dynamic radius and the measured C...
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Biochem J (2010) 432 (2): 407–416.
Published: 12 November 2010
.... In the present study, we performed detailed characterization of the interaction of 4.1G with various erythroid membrane proteins and the regulation of these interactions by calcium-saturated calmodulin. Like both isoforms of 4.1R, 4.1G bound to band 3, glycophorin C, CD44, p55 and calmodulin. While both 4.1G...
Includes: Supplementary data
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Biochem J (2010) 430 (3): 453–460.
Published: 27 August 2010
..., provided the original work is properly cited. calcium endoplasmic reticulum (ER) Golli myelin basic protein (MBP) store-operated Ca 2+ entry (SOCE) stromal interaction molecule 1 (STIM1) Ca 2+ signalling controls many cellular processes including cell growth, secretion...
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Biochem J (2010) 427 (2): 275–287.
Published: 29 March 2010
... . 4 Present address: Laboratory of Microbial Engineering, Division of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan. 5 To whom correspondence should be addressed (email y_inoue@kais.koyoto-u.ac.jp ). calcineurin calcium Crz1 FK506 methylglyoxal Msn2/Msn4...
Includes: Supplementary data
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Biochem J (2010) 426 (3): 327–335.
Published: 24 February 2010
... 2010 13 1 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 calcium matrix metalloproteinase-9 (MMP-9) metastasis S100A4 Smad3 transforming growth factor-β (TGF-β) Retrovirus-infected MCF10CA1a.cl1 cells or siRNA-transfected MDA-MB 231 cells in 60 mm...
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Biochem J (2010) 425 (1): 27–40.
Published: 14 December 2009
...-hand Ca 2+ sensors in plants are CaMs [calmodulins; including CMLs (CaM-like proteins)], CDPKs (calcium-dependent protein kinases) and CBLs (calcineurin B-like proteins). In the plant species examined to date, each of these classes is represented by a large family of proteins, most of which have...
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Biochem J (2009) 423 (1): 53–59.
Published: 14 September 2009
... asporin fragment LRR (leucine-rich repeat) 10–12 and by full-length decorin, but not by biglycan. We demonstrate that the polyaspartate domain binds calcium and regulates hydroxyapatite formation in vitro . In the presence of asporin, the number of collagen nodules, and mRNA of osteoblastic markers...
Includes: Supplementary data
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Biochem J (2009) 419 (1): 91–99.
Published: 13 March 2009
... a novel means of excitation of autonomic neurons. calcium nicotinic acid–adenine dinucleotide phosphate (NAADP) non-selective cation channel patch-clamp NAADP (nicotinic acid–adenine dinucleotide phosphate) is a potent mobilizer of intracellular Ca 2+ stores [ 1 , 2 ]. The actions...
Includes: Supplementary data
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Biochem J (2009) 417 (3): 667–672.
Published: 16 January 2009
... Biochemical Society 2009 AtoS-AtoC two-component system atoDAEB calcium calcium channel blocker histamine poly-(R)-3-hydroxybutyrate Ca 2+ is implicated in the regulation of a wide variety of cellular processes, including signal transduction in bacteria, where cytosolic Ca 2+ levels...
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Biochem J (2008) 416 (1): 77–84.
Published: 28 October 2008
... Biochemical Society 2008 calcium cholecystokinin ferric ion iron phosphotyrosine sulfotyrosine Modification of tyrosine residues is a critical post-translational modification of many proteins. Tyrosine sulfation occurs in the trans -Golgi network, and is thought to be important in protein...
Includes: Supplementary data
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Biochem J (2008) 415 (3): 409–416.
Published: 15 October 2008
... and manganese were identified, in addition to calcium (Ca 2+ ) and H + as potent inhibitors of WT At PIP2;1. Our results further show that His 199 , the previously identified site for H + sensing, but also N-terminal located Glu 31 , and to a lesser extent Asp 28 , are involved in both divalent-cation- and H...
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