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Keywords: atherosclerosis
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Biochem J (2021) 478 (7): 1359–1375.
Published: 16 April 2021
...MD Khurshidul Zahid; Hazera Binte Sufian; Mahua Choudhury; Masao Yamasaki; Ahmed Al-Harrasi; Naima Moustaid-Moussa; Shaikh Mizanoor Rahman Atherosclerosis is a chronic inflammatory disease associated with lipid metabolism disorder. Autophagy is a catabolic process and contributes to maintaining...
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Biochem J (2016) 473 (10): 1281–1295.
Published: 11 May 2016
... cell function during atherosclerotic plaque formation. atherosclerosis extracellular matrix inflammation microenvironment shear stress Atherosclerosis is a lipid-driven chronic inflammatory disease of large and medium sized arteries, hinders arterial function and prevents adequate blood...
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Biochem J (2015) 472 (3): 249–259.
Published: 27 November 2015
.... Here we discuss the design principles, mechanisms of action, indications and efficacy of lipoprotein mimetics. apolipoproteins atherosclerosis cholesterol metabolism lipoprotein metabolism peptides A novel mechanism of clearance of plasma lipoproteins mimicking elements of forward...
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Biochem J (2013) 454 (1): 1–11.
Published: 26 July 2013
...Robert Stöhr; Massimo Federici For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited...
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Biochem J (2013) 451 (3): 375–388.
Published: 12 April 2013
... should be addressed (email bradford.hill@louisville.edu ). 27 8 2012 12 2 2013 20 2 2013 20 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 atherosclerosis autophagy growth factor 4-hydroxy-nonenal (4-HNE) restenosis spautin VSMCs...
Includes: Supplementary data
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Biochem J (2010) 428 (2): 269–279.
Published: 13 May 2010
... 3 2010 23 3 2010 23 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 atherosclerosis inflammation lipoprotein oxidized phospholipid phospholipase platelet-activating factor (PAF) PAF-AH [PAF (platelet-activating factor; 1-O-alkyl-2-acetyl...
Includes: Supplementary data
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Biochem J (2010) 428 (1): 47–54.
Published: 28 April 2010
... and phosphoc-Jun (Ser 63 ). Immunoreactive bands were detected by incubation with HRP-conjugated secondary antibodies and then visualized by chemiluminescence. apolipoprotein E (apoE) atherosclerosis c-Jun N-terminal kinase (JNK) inflammation lipoprotein receptor macrophage All values...
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Biochem J (2009) 420 (2): 277–281.
Published: 13 May 2009
... of Gerry et al. [ 12 ]. 1 To whom correspondence should be addressed (email bernhard.gmeiner@meduniwien.ac.at ). 19 12 2008 2 3 2009 5 3 2009 5 3 2009 atherosclerosis hydrogen sulfide (H 2 S) low-densitylipoprotein (LDL) oxidation lipid hydroperoxide (9 S...
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Biochem J (2008) 410 (3): 525–534.
Published: 27 February 2008
... To whom correspondence should be addressed (email aruni@louisville.edu ). 6 8 2007 27 11 2007 3 12 2007 3 12 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 atherosclerosis autophagy 4-hydroxynonenal (4-HNE) oxidative stress oxidized lipid...
Includes: Supplementary data
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Biochem J (2007) 407 (1): 79–87.
Published: 12 September 2007
.... Samples were washed extensively with the immunoprecipitation buffer, resolved by SDS/PAGE and subjected to Western blotting. apoptosis atherosclerosis histone deacetylase (HDAC) insulin-like growth factor 1 receptor (IGF1R) p53 vascular smooth-muscle cell (VSMC) Atherosclerosis...
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Biochem J (2007) 406 (2): 203–207.
Published: 13 August 2007
.... 50% lower in Pcsk9 knockout mice owing to increased clearance of lipoproteins from plasma [ 7 ]. No apparent physiological or behavioural abnormality was observed from knockout mice or from a human subject carrying compound heterozygous loss-of-function mutations [ 7 , 8 ]. atherosclerosis...
Includes: Supplementary data
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Biochem J (2007) 405 (1): 95–105.
Published: 13 June 2007
... ]. Although under normal physiological conditions, antioxidant defences prevent excessive oxidation, products of lipid peroxidation accumulate under several pathological states, most notably, atherosclerosis [ 2 ] and Alzheimer's disease [ 3 ], myocardial ischaemia/reperfusion [ 4 ], and heart failure [ 5...
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Biochem J (2005) 385 (3): 823–830.
Published: 24 January 2005
...Carmel M. QUINN; Wendy JESSUP; Jenny WONG; Leonard KRITHARIDES; Andrew J. BROWN CYP27A1 (sterol 27-hydroxylase) catalyses an important sterol elimination pathway in the human macrophage, and consequently may protect against atherosclerosis. We studied the expression and regulation of CYP27A1...
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Biochem J (2004) 382 (2): 417–424.
Published: 24 August 2004
... in part, to the anti-atherosclerotic effect of GHRPs in apolipoprotein E-deficient mice. atherosclerosis CD36 growth hormone-releasing peptide hexarelin oxidized low-density lipoprotein photoaffinity labelling The GHRPs (growth hormone-releasing peptides) comprise a family of small...
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Biochem J (2003) 376 (3): 765–771.
Published: 15 December 2003
... approx. 5-fold greater binding and 2-fold faster degradation of native Lp(a) com- pared with control cells. Our results for the first time demonstrate a physiological function of ASGPR in the catabolism of Lp(a). Key words: adenoviral vector, atherosclerosis, glycoprotein, hedgehog, lipoprotein...
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Biochem J (2003) 370 (2): 729–735.
Published: 01 March 2003
...Alan A. WOODS; Stuart M. LINTON; Michael J. DAVIES Oxidation is believed to play a role in atherosclerosis. Oxidized lipids, sterols and proteins have been detected in early, intermediate and advanced human lesions at elevated levels. The spectrum of oxidized side-chain products detected...
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Biochem J (2003) 370 (1): 339–344.
Published: 15 February 2003
...Lincoln W. MORTON; Ian B. PUDDEY; Kevin D. CROFT The importance of reactive nitrogen species in atherosclerosis remains poorly understood, despite the semi-quantitative evidence for the presence of 3-nitrotyrosine provided by immunohistochemical staining studies. At this time, there appear...
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Biochem J (2001) 357 (2): 457–464.
Published: 09 July 2001
... and acetylhydrolase activities which remove PAF and its ether-linked analogues from LDL particles upon LDL oxidation. However, in atherogenic small dense LDL-5 particles, the transacetylase activity may acetylate extracellular lyso-PAF into biologically active PAF. Key words: atherosclerosis, inflammation...
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Biochem J (2001) 354 (1): 1–7.
Published: 08 February 2001
... not contain PON1, was unable to hydrolyse PAF. These data provide evidence that PON1 may limit the action of this bioactive pro-inflammatory phospholipid. Key words: PON1, PAF acetylhydrolase, atherosclerosis, inflammation. decreased by 25%. HDL from the PON1 knock-out mice is pro- inflammatory, indicating...
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Biochem J (2001) 353 (3): 493–501.
Published: 25 January 2001
...@bcm.tmc.edu ). 3 8 2000 25 10 2000 13 11 2000 The Biochemical Society, London © 2001 2001 atherosclerosis lactacystin lipoproteins proteasome ubiquitin Biochem. J. (2001) 353, 493 501 (Printed in Great Britain) 493 Tunicamycin induces ubiquitination and degradation...
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Biochem J (2000) 352 (3): 601–610.
Published: 08 December 2000
... activity, is associated with a variety of cancers. Key words: atherosclerosis, cancer, fibrillin, Marfan s syndrome, TGFb. many normal cellular functions. Consistent with these multiple roles, anomalous regulation of TGFb activity has been associated with the development of a number of diseases, most...
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Biochem J (1999) 344 (1): 7–13.
Published: 08 November 1999
... of cholesterol and phospholipid. The implications of these findings for atherosclerosis and Alzheimer's disease are discussed. 1 To whom correspondence should be addressed (e-mail schreibe@biochem.bumc.bu.edu). 2 Present address: National Institutes of Health, SSS2, CSR, 6701 Rockledge Drive...