..., asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase...

.... Macrophages contribute to allergic inflammation in asthma. The present study was aimed to investigate the effect of NLRP3 inflammasome on the polarization of macrophages. We utilized human primary monocytes and monocyte-derived macrophages to study the expression of NLRP3 inflammasome components (NLRP3...

.... Hilton; Andrew D. Nash; Jian-Guo Zhang; Nicos A. Nicola Gene deletion studies in mice have revealed critical roles for IL (interleukin)-4 and -13 in asthma development, with the latter controlling lung airways resistance and mucus secretion. We have now developed human neutralizing monoclonal antibodies...

...Eric J. Sundberg Asthma is a debilitating chronic inflammatory disease of the airways that results in shortness of breath, wheezing and coughing, often triggered by inhalation of common allergens. The prevalence and severity of asthma has increased dramatically over the last several decades...

... component of the inflammatory response observed in several clinically important diseases, notably allergic diseases such as asthma. Consequently, much time and effort has been directed towards understanding which chemokine receptors and ligands are important in the allergic response with a view...

... to be mediated by KLK1. In an allergic sheep model of asthma, DX-2300 inhibited both allergen-induced late-phase bronchoconstriction and airway hyper-responsiveness to carbachol. These studies demonstrate that DX-2300 is a potent and specific inhibitor of KLK1 that is efficacious in in vitro and in vivo models...

... in regulating cAMP levels in specific cell types. Key words: alternative mRNA splicing, asthma, cAMP, phosphodiesterase, phosphoric ester hydrolase, rolipram. shown that additional diversity in this family is produced by alternative mRNA splicing ([5 9,9a] ; see [3] for a review). The use of different exons...

... 2002 The Biochemical Society, London ©2003 2003 arrestin asthma chronic obstructive pulmonary disease (COPD) phosphorylation rolipram targeting Abbreviations used: AKAP, A-kinase anchoring protein; β 2 -AR, β 2 -adrenoceptor; cAMP-GEFs, cAMP-activated GTP-exchange factors...

... Society, London ©2002 2002 asthma chronic obstructive pulmonary disease cystic fibrosis Abbreviations used: BCIP, 5-bromo-4-chloroindol-3-yl phosphate; CF, cystic fibrosis; COPD, chronic obstructive pulmonary disease; GdmCl, guanidinium chloride; PAS, periodate—Schiff. Biochem. J...

... that it might be a point of control for mucin size and thus mucus rheology. 1 To whom correspondence should be addressed (e-mail jsheehan@fs1.scg.man.ac.uk ). 1 10 1998 2 12 1998 22 12 1998 The Biochemical Society, London © 1999 1999 asthma gel-forming mucins mucus...