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Keywords: apoptosis
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Articles
Biochem J (2022) 479 (15): 1621–1651.
Published: 05 August 2022
... to treat certain inflammatory skin diseases. Programmes to develop such inhibitors are already underway. In this review, we outline the mechanisms of skin-associated cell death programmes; apoptosis, necroptosis, pyroptosis, NETosis, and the epidermal terminal differentiation programme, cornification. We...
Articles
Biochem J (2022) 479 (14): 1581–1608.
Published: 29 July 2022
... therapeutic regimes is needed. Recent studies indicate that modulation of autophagy in concert with apoptosis induction may provide a promising novel strategy in breast cancer treatment. Apoptosis and autophagy are two tightly regulated distinct cellular processes. To maintain tissue homeostasis abnormal...
Articles
Biochem J (2022) 479 (10): 1103–1119.
Published: 24 May 2022
...Kim Newton; Alexander D. Gitlin Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational modification...
Articles
Biochem J (2022) 479 (10): 1083–1102.
Published: 24 May 2022
... downstream of inflammasome activation, death receptor and mitochondrial apoptosis, and necroptosis. This new era in cell death research therefore holds significant promise in identifying how distinct, yet often networked, pyroptotic cell death pathways might be manipulated for therapeutic benefit to treat...
Articles
Biochem J (2022) 479 (9): 929–951.
Published: 06 May 2022
...-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage...
Articles
Biochem J (2022) 479 (5): 677–685.
Published: 16 March 2022
...@med.toho-u.ac.jp ) 2 2 2022 23 2 2022 25 2 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 apoptosis DAMPs ESCRT HMGB1 imaging techniques necroptosis Necrosis is characterized by cell swelling and plasma...
Includes: Supplementary data
Articles
Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Covid-19 inflammation necroptosis pyroptosis therapeutics On New Years eve 2019, media reports emerged ∼27 cases of viral pneumonia in the central city of Wuhan, China [ 1 ]. Within the following two weeks...
Articles
Biochem J (2022) 479 (3): 357–384.
Published: 11 February 2022
...Laura Lossi Regulated cell death is a vital and dynamic process in multicellular organisms that maintains tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better-known forms of regulated cell death, is activated when cell-surface death receptors like Fas...
Articles
Biochem J (2022) 479 (1): 75–90.
Published: 14 January 2022
... this cross-talk is disrupted, in the context of disease. Correspondence: Nektarios Tavernarakis ( tavernarakis@imbb.forth.gr ) 14 11 2021 21 12 2021 23 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 apoptosis...
Articles
Biochem J (2021) 478 (13): 2681–2696.
Published: 16 July 2021
...Alexandre Desroches; Jean-Bernard Denault Apoptosis is a regulated form of cell death essential to the removal of unwanted cells. At its core, a family of cysteine peptidases named caspases cleave key proteins allowing cell death to occur. To do so, each caspase catalytic pocket recognizes...
Articles
Biochem J (2021) 478 (8): 1547–1569.
Published: 21 April 2021
... 3 2021 22 3 2021 29 3 2021 29 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 alpha kinase apoptosis cancer therapy protein synthesis translation Both autophagy and eEF2K are inhibited by signalling...
Includes: Supplementary data
Articles
Biochem J (2021) 478 (7): 1359–1375.
Published: 16 April 2021
... Press Limited on behalf of the Biochemical Society 2021 apoptosis atherosclerosis autophagy bioactive compounds foam cells macrophage Atherosclerosis is associated with chronic inflammation and dysregulated lipid metabolism and contributes to myocardial infarction and sudden death [ 1...
Articles
Biochem J (2021) 478 (3): 669–684.
Published: 12 February 2021
... ( liz.ledgerwood@otago.ac.nz ) * Present address: InterX, Tel-Aviv, Israel. 11 10 2020 17 1 2021 21 1 2021 22 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 apoptosis apoptosome cytochrome c molecular dynamics...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (23): 4527–4541.
Published: 03 December 2020
...Chathura D. Suraweera; Mark G. Hinds; Marc Kvansakul Premature apoptosis of cells is a strategy utilized by multicellular organisms to counter microbial threats. Orf virus (ORFV) is a large double-stranded DNA virus belonging to the poxviridae . ORFV encodes for an apoptosis inhibitory protein...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (17): 3287–3297.
Published: 10 September 2020
...Suresh Banjara; Jaison D Sa; Mark G. Hinds; Marc Kvansakul Apoptosis is regulated by evolutionarily conserved signaling pathways to remove damaged, diseased or unwanted cells. Proteins homologous to the B-cell lymphoma 2 (Bcl-2) family of proteins, the primary arbiters of mitochondrially mediated...
Articles
Biochem J (2020) 477 (17): 3147–3165.
Published: 04 September 2020
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Open access for this article was enabled by the participation of University of Minnesota in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society. apoptosis lectin...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (12): 2383–2399.
Published: 26 June 2020
.... For A549 cells, L 2 and L 3 had higher anti-A549 activity. Furthermore, L 1 and L 3 may be the great promise antiproliferative drugs with nontoxic side effects, due to the high anti-HepG2 and anti-MCF-7 inhibition rate in vivo , 65% and 61%, respectively. L 1 , L 2 and L 3 could induce apoptosis through...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (1): 137–160.
Published: 10 January 2020
... while increasing caspase-3 dependent apoptosis. Additionally, inhibition of the TFEB-phosphatase calcineurin sensitized cells to DOX-induced apoptosis in a TFEB dependent fashion. Regulation of apoptosis by TFEB was not a consequence of altered lysosomal function, as TFEB continued to protect against...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (10): 1445–1463.
Published: 21 May 2019
... in oligomerization, stability and hence the formation of a functional enzyme. In silico structural comparison of HtrA4 with other human HtrAs, enzymology studies and cleavage assays with X-linked inhibitor of apoptosis protein (XIAP) show overall structural conservation and allosteric mode of protease activation...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (5): 889–907.
Published: 15 March 2019
.... 18 10 2018 18 2 2019 27 2 2019 27 2 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 amyloid apoptosis Azadirachtin hIAPP molecular dynamics pancreatic β-cell Aberrant misfolding of proteins and peptides...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (6): 1177–1196.
Published: 29 March 2018
...Kristen L. Huber; Banyuhay P. Serrano; Jeanne A. Hardy Caspase-9 is a critical factor in the initiation of apoptosis and as a result is tightly regulated by many mechanisms. Caspase-9 contains a Caspase Activation and Recruitment Domain (CARD), which enables caspase-9 to form a tight interaction...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (24): 4065–4074.
Published: 01 December 2017
...Biao Dong; Xiaolu Zhang; Yafeng Fan; Songqiang Cao; Xuepei Zhang The aim of the present study was to investigate the effects and molecular mechanisms of GPR4 (G-protein-coupled receptor 4) in cell apoptosis and renal ischemia–reperfusion (IR) injury in vivo and in vitro . GPR4 −/− mice and wild...
Articles
Biochem J (2017) 474 (23): 3915–3934.
Published: 16 November 2017
... (T2DM). The human islet amyloid polypeptide (hIAPP) forms amyloid plaques in the pancreas of T2DM subjects (>95%) that are involved in deteriorating islet function and in mediating β - cell apoptosis. However, the detailed mechanism of action, structure and nature of toxic hIAPP species responsible...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (22): 3767–3781.
Published: 06 November 2017
... by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis cytotoxicity domain swapping onconase protein oligomerization ribonucleases Onconase® (ONC, Alfacell Corporation, Somerset, NJ, U.S.A.), earlier named P30 protein [ 1 ], is a monomeric member of the secretory...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (21): 3643–3657.
Published: 23 October 2017
... may provide a means to deepen responses to venetoclax and extend the utility to additional indications. Here, we review recent progress in direct and selective targeting of Bcl-2 family proteins for cancer therapy and the search for rationale combinations. Apoptosis is a highly regulated form...
Articles
Biochem J (2017) 474 (18): 3093–3107.
Published: 31 August 2017
... by inoculating lentiviral particles carrying the sequence of a short-hairpin RNA targeting Gpat2 mRNA into mouse testis. Histological and gene expression analysis showed impaired spermatogenesis and arrest at the pachytene stage. Defects in reproductive fitness were also observed, and the analysis of apoptosis...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (17): 3011–3025.
Published: 22 August 2017
... dysplasia led to the inhibition of SCC, thereby reducing the tumor burden. The antioxidant capacity of AN and EG was also brought out via biochemical analysis. Further investigation of biomarkers in tongue tissues revealed the involvement of apoptosis in vivo . Moreover, no adverse or toxic effect...
Articles
Biochem J (2017) 474 (17): 3027–3043.
Published: 22 August 2017
.... Periplanetasin-2 induced oxidative stress by generation of reactive oxygen species (ROS) and lipid peroxidation. Periplanetasin-2 also caused apoptosis by exposure of phosphatidylserine and fragmentation of DNA, exerted in a concentration-dependent manner. Hence, we investigated the mitochondrial apoptotic...
Articles
Biochem J (2016) 473 (19): 2973–2994.
Published: 27 September 2016
... factor for NMSC is ultraviolet radiation (UVR) from sunlight, specifically UVB, which is the leading cause of DNA damage, photoaging, and malignant transformation in the skin. Activation of apoptosis following UVR exposure allows the elimination of irreversibly damaged cells that may harbor oncogenic...
Articles
Biochem J (2016) 473 (8): 1073–1083.
Published: 08 April 2016
... by Bcl-2 homology 3 domain (BH3) proteins. Some of the compounds induced Bax/Bak-dependent apoptosis in cells. Activation of Bax by the most active compound was poorly inhibited by the anti-apoptotic protein Bcl-XL and requires a cysteine residue at position 126 of Bax that is not required for activation...
Includes: Supplementary data
Articles
Biochem J (2015) 470 (1): 145–154.
Published: 06 August 2015
...Hsiang Yu; Huey-Jen Lai; Tai-Wei Lin; Chang-Shi Chen; Szecheng J. Lo Three waves of apoptosis shape the development of Caenorhabditis elegans . Although the exact roles of the three DNase II genes ( nuc-1 , crn-6 and crn-7 ), which are known to mediate degradation of apoptotic DNA, in the embryonic...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2015) 469 (2): 315–324.
Published: 06 July 2015
... also induced expression of lipocalin 2 ( Lcn2 ) and other NF-κB (nuclear factor κB)-related genes. siRNA-induced apoptosis was inhibited by Lcn2 repression or NF-κB inhibitors. This is the first report on Pla2g4c gene-deficient rats and their low susceptibility to mammary carcinogenesis by enhancing NF...
Articles
Biochem J (2015) 467 (3): 495–505.
Published: 17 April 2015
...Aisha Shamas-Din; Scott Bindner; Xiaoke Chi; Brian Leber; David W. Andrews; Cécile Fradin tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL...
Articles
Biochem J (2015) 466 (3): 537–546.
Published: 06 March 2015
...+ is intracellular, found largely sequestered in lysosomes. Lysosomes express TRPM2 channels, providing a potential route for Zn 2+ release. Zn 2+ release is potentiated by extracellular Ca 2+ entry, indicating that Ca 2+ -induced Zn 2+ release leads to apoptosis. Knockout of TRPM2 channels protects mice from β...
Includes: Supplementary data
Articles
Biochem J (2015) 465 (1): 115–125.
Published: 12 December 2014
... no such effects. The chaperone activities of the peptides were better than those from αA- and αB-crystallin. HeLa cells took up the FITC-conjugated Hsp20 peptide and, when the cells were thermally stressed, the peptide was translocated from the cytoplasm to the nucleus. The two peptides inhibited apoptosis...
Articles
Biochem J (2014) 464 (3): 439–447.
Published: 05 December 2014
...Ho Tsoi; Li Li; Zhefan S. Chen; Kwok-Fai Lau; Stephen K. W. Tsui; Ho Yin Edwin Chan A number of viral gene products are capable of inducing apoptosis by interfering with various cellular signalling cascades. We previously reported the pro-apoptotic property of the SARS-CoV (severe acute respiratory...
Includes: Supplementary data
Articles
Biochem J (2014) 462 (3): 489–497.
Published: 22 August 2014
... transgene protects cortical neurons from H 2 O 2 -induced apoptosis, and this protective effect is abrogated by knocking down RACK1. Similarly, deletion of DJ-1 in cortical neurons increases the sensitivity to H 2 O 2 , and the damage can be significantly rescued by DJ-1 or DJ-1/RACK1 co-transfection...
Articles
Biochem J (2014) 462 (2): 267–277.
Published: 07 August 2014
... differentiation. During myoblast differentiation, autophagy is mediated by JNK activity through regulation of BECN1–BCL2 association. Inhibition of autophagy impairs myoblast differentiation and increases apoptotic cell death. apoptosis autophagy beclin 1 (BECN1) caspase 3 (CASP3) differentiation...
Articles
Biochem J (2014) 459 (3): 513–524.
Published: 11 April 2014
... In contrast with BIM EL , the increase in expression of the pro-apoptotic protein BIK following inhibition of ERK1/2 signalling is likely to be a consequence of G 1 cell-cycle arrest and not a direct effect on BIK protein stability. apoptosis BCL2-interacting killer (BIK) BCL2-interacting mediator...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (2): 397–404.
Published: 28 March 2014
...Shang H. Lin; Nuval Cherian; Benjamin Wu; Hyo Phee; Christy Cho; Marco Colombini Bax, despite being a cytosolic protein, has the distinct ability to form channels in the mitochondrial outer membrane, which are capable of releasing proteins that initiate the execution phase of apoptosis. When...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (1): 149–160.
Published: 14 March 2014
... of MERRF syndrome in the future. Figure 5 CA8 expression protected MERRF cells from apoptosis under pro-apoptotic agent (STS) treatment ( A ) Expression of CA8 in cybrid clones D5-1 (wild-type), C5 (MERRF mutant), C5-Luc (C5 cybrids infected with Luc-shRNA) and C5-CA8 (C5 cybrids infected...
Articles
Biochem J (2014) 458 (2): 259–265.
Published: 14 February 2014
...Tracy M. Josephs; Ian M. Morison; Catherine L. Day; Sigurd M. Wilbanks; Elizabeth C. Ledgerwood The peroxidase activity of cytochrome c may play a key role in the release of cytochrome c from the mitochondrial intermembrane space in the intrinsic apoptosis pathway. Induction of the peroxidase...
Includes: Supplementary data
Articles
Biochem J (2014) 457 (1): 151–162.
Published: 10 December 2013
... shown that miRNAs are extensively involved in the pathogenesis of cardiac hypertrophy. In the present study, we examined the hypothesis that the miR-19a/b family acts as a key regulator of cardiac hypertrophy and apoptosis. Forced overexpression of miR-19a/b was sufficient to induce hypertrophy in rat...
Includes: Supplementary data
Articles
Biochem J (2013) 456 (3): 323–335.
Published: 22 November 2013
... cell and initiation of pore formation. apoptosis C2 domain cytotoxic lymphocyte perforin pore-forming protein The pore-forming protein, PRF (perforin; PRF1 gene), is stored and secreted by cytotoxic lymphocytes [CTLs (cytotoxic T-lymphocytes) and natural killer cells...
Articles
Biochem J (2013) 456 (2): 185–194.
Published: 08 November 2013
... of cysts with coarse shells in which two chitin-binding proteins were missing. Western blotting showed that the level of trehalase was increased and apoptosis was induced in these ArTAP-knockdown cysts compared with controls. Taken together, these results show that ArTAP is a key regulator of trehalase...
Includes: Supplementary data
Articles
Biochem J (2013) 454 (2): 249–257.
Published: 09 August 2013
... To whom correspondence should be addressed (email zhanja@uab.edu ). 19 3 2013 13 6 2013 17 6 2013 17 6 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 apoptosis autophagy c-Jun c-Jun N-terminal kinase (JNK) sirtuin 3 Autophagy...
Includes: Supplementary data
Articles
Biochem J (2013) 453 (3): 321–336.
Published: 12 July 2013
... (email d.richardson@med.usyd.edu.au ). 14 1 2013 12 4 2013 15 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 apoptosis autophagy cardiomyopathy frataxin Friedreich's ataxia integrated stress response FRDA (Friedreich's ataxia...
Articles
Biochem J (2013) 452 (2): 281–291.
Published: 10 May 2013
...Shanshan Li; Yajuan Ran; Dandan Zhang; Jianguo Chen; Shuzhen Li; Daling Zhu Unbalanced apoptosis is a major cause of structural remodelling of vasculatures associated with PAH (pulmonary arterial hypertension), whereas the underlying mechanisms are still elusive. miRNAs (microRNAs) regulate...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (1): 111–119.
Published: 25 April 2013
... tBid (purchased from AnaSpec) at 37°C. Where indicated, recombinant proteins were added to microsomes 15 min before to the initiation of the enzymatic reaction (achieved via the addition of substrates). ABT-263 ABT-737 apoptosis BCL2 ceramide haematology leukaemia sphingolipid One...
Includes: Supplementary data
Articles
Biochem J (2013) 452 (1): 147–159.
Published: 25 April 2013
...-1 results in an increase in the binding of GAPDH and its protein partner HMG (high-mobility group) B1 to the chromatin. Regarding the multiple roles of GAPDH in apoptosis and DNA repair, the cytotoxic and apoptotic activities of GAPDH were evaluated and present opposite effects in two different...
Includes: Supplementary data