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Keywords: apoptosis
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Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (22): 2351–2364.
Published: 23 November 2022
...Enoli De Silva; Dana V. Devine; Eric Jan; Calvin D. Roskelley; Hugh Kim Apoptosis is a critical process for the maintenance of cell populations, and involves mitochondrial depolarization, the sequential cleavage of caspase-9 and -3, followed by the externalization of phosphatidylserine (PS...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (19): 2049–2062.
Published: 14 October 2022
...Bart Tummers; Douglas R. Green Apoptosis and necroptosis regulate many aspects of organismal biology and are involved in various human diseases. TNF is well known to induce both of these forms of cell death and the underlying mechanisms have been elaborately described. However, cells can also...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (15): 1621–1651.
Published: 05 August 2022
... to treat certain inflammatory skin diseases. Programmes to develop such inhibitors are already underway. In this review, we outline the mechanisms of skin-associated cell death programmes; apoptosis, necroptosis, pyroptosis, NETosis, and the epidermal terminal differentiation programme, cornification. We...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (14): 1581–1608.
Published: 29 July 2022
... therapeutic regimes is needed. Recent studies indicate that modulation of autophagy in concert with apoptosis induction may provide a promising novel strategy in breast cancer treatment. Apoptosis and autophagy are two tightly regulated distinct cellular processes. To maintain tissue homeostasis abnormal...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (10): 1103–1119.
Published: 24 May 2022
...Kim Newton; Alexander D. Gitlin Apoptosis, pyroptosis, and necroptosis are distinct forms of programmed cell death that eliminate infected, damaged, or obsolete cells. Many proteins that regulate or are a part of the cell death machinery undergo ubiquitination, a post-translational modification...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (10): 1083–1102.
Published: 24 May 2022
... downstream of inflammasome activation, death receptor and mitochondrial apoptosis, and necroptosis. This new era in cell death research therefore holds significant promise in identifying how distinct, yet often networked, pyroptotic cell death pathways might be manipulated for therapeutic benefit to treat...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (9): 929–951.
Published: 06 May 2022
...-translational modifications in control of its function. Ubiquitination by E3 ligases, such as inhibitors of apoptosis (IAP) proteins and LUBAC, as well as the reversal of these modifications by deubiquitinating enzymes, such as A20 and CYLD, can greatly influence RIP1 mediated signaling. In addition, cleavage...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (5): 677–685.
Published: 16 March 2022
...@med.toho-u.ac.jp ) 2 2 2022 23 2 2022 25 2 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 apoptosis DAMPs ESCRT HMGB1 imaging techniques necroptosis Necrosis is characterized by cell swelling and plasma...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (5): 609–628.
Published: 04 March 2022
... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . apoptosis Covid-19 inflammation necroptosis pyroptosis therapeutics On New Years eve 2019, media reports emerged ∼27...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (3): 357–384.
Published: 11 February 2022
...Laura Lossi Regulated cell death is a vital and dynamic process in multicellular organisms that maintains tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better-known forms of regulated cell death, is activated when cell-surface death receptors like Fas...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (1): 75–90.
Published: 14 January 2022
... this cross-talk is disrupted, in the context of disease. Correspondence: Nektarios Tavernarakis ( tavernarakis@imbb.forth.gr ) 14 11 2021 21 12 2021 23 12 2021 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 apoptosis...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (13): 2681–2696.
Published: 16 July 2021
...Alexandre Desroches; Jean-Bernard Denault Apoptosis is a regulated form of cell death essential to the removal of unwanted cells. At its core, a family of cysteine peptidases named caspases cleave key proteins allowing cell death to occur. To do so, each caspase catalytic pocket recognizes...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (8): 1547–1569.
Published: 21 April 2021
... ) 1 3 2021 22 3 2021 29 3 2021 29 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 alpha kinase apoptosis cancer therapy protein synthesis translation Cells within solid tumours may be subject...
Includes: Supplementary data
Articles
MD Khurshidul Zahid, Hazera Binte Sufian, Mahua Choudhury, Masao Yamasaki, Ahmed Al-Harrasi, Naima Moustaid-Moussa, Shaikh Mizanoor Rahman
Journal:
Biochemical Journal
Biochem J (2021) 478 (7): 1359–1375.
Published: 16 April 2021
... neurodegeneration and aging while autophagy activation promotes life span [ 16 , 17 ]. 15 11 2020 16 3 2021 17 3 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 apoptosis atherosclerosis autophagy bioactive compounds foam...
Articles
Matthias Fellner, Rinky Parakra, Kirstin O. McDonald, Itamar Kass, Guy N.L. Jameson, Sigurd M. Wilbanks, Elizabeth C. Ledgerwood
Journal:
Biochemical Journal
Biochem J (2021) 478 (3): 669–684.
Published: 12 February 2021
.... These data highlight that conformational dynamics of cytochrome c drive some but not all of its properties and activities. 11 10 2020 17 1 2021 21 1 2021 22 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 apoptosis...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (23): 4527–4541.
Published: 03 December 2020
...Chathura D. Suraweera; Mark G. Hinds; Marc Kvansakul Premature apoptosis of cells is a strategy utilized by multicellular organisms to counter microbial threats. Orf virus (ORFV) is a large double-stranded DNA virus belonging to the poxviridae . ORFV encodes for an apoptosis inhibitory protein...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3287–3297.
Published: 10 September 2020
...Suresh Banjara; Jaison D Sa; Mark G. Hinds; Marc Kvansakul Apoptosis is regulated by evolutionarily conserved signaling pathways to remove damaged, diseased or unwanted cells. Proteins homologous to the B-cell lymphoma 2 (Bcl-2) family of proteins, the primary arbiters of mitochondrially mediated...
Articles
Michelle C. Miller, Irina V. Nesmelova, Vladimir A. Daragan, Hans Ippel, Malwina Michalak, Aurelio Dregni, Herbert Kaltner, Jürgen Kopitz, Hans-Joachim Gabius, Kevin H. Mayo
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3147–3165.
Published: 04 September 2020
... and the Biochemical Society. apoptosis lectin molecular dynamics NMR relaxation NMR spectroscopy site-directed mutagenesis 24 6 2020 3 8 2020 6 8 2020 7 8 2020 Screening for up- or down-regulation of expression of distinct genes upon changing a specific parameter...
Includes: Supplementary data
Articles
Fengyi Zhao, Wen Lu, Yuanyuan Xu, Li Xu, Jingjing Zhang, Xu Sun, Shilong Yang, Mengyi Zhou, Fan Su, Feng Lin, Fuliang Cao
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2383–2399.
Published: 26 June 2020
.... For A549 cells, L 2 and L 3 had higher anti-A549 activity. Furthermore, L 1 and L 3 may be the great promise antiproliferative drugs with nontoxic side effects, due to the high anti-HepG2 and anti-MCF-7 inhibition rate in vivo , 65% and 61%, respectively. L 1 , L 2 and L 3 could induce apoptosis through...
Includes: Supplementary data
Articles
Logan Slade, Dipsikha Biswas, Francis Ihionu, Yassine El Hiani, Petra C. Kienesberger, Thomas Pulinilkunnil
Journal:
Biochemical Journal
Biochem J (2020) 477 (1): 137–160.
Published: 10 January 2020
... while increasing caspase-3 dependent apoptosis. Additionally, inhibition of the TFEB-phosphatase calcineurin sensitized cells to DOX-induced apoptosis in a TFEB dependent fashion. Regulation of apoptosis by TFEB was not a consequence of altered lysosomal function, as TFEB continued to protect against...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (10): 1445–1463.
Published: 21 May 2019
... in oligomerization, stability and hence the formation of a functional enzyme. In silico structural comparison of HtrA4 with other human HtrAs, enzymology studies and cleavage assays with X-linked inhibitor of apoptosis protein (XIAP) show overall structural conservation and allosteric mode of protease activation...
Includes: Supplementary data
Articles
Richa Dubey, Ketaki Patil, Sarath C. Dantu, Devika M. Sardesai, Parnika Bhatia, Nikita Malik, Jhankar D. Acharya, Soham Sarkar, Soumadwip Ghosh, Rajarshi Chakrabarti, Shilpy Sharma, Ashutosh Kumar
Journal:
Biochemical Journal
Biochem J (2019) 476 (5): 889–907.
Published: 15 March 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 amyloid apoptosis Azadirachtin hIAPP molecular dynamics pancreatic β-cell Aberrant misfolding of proteins and peptides into insoluble fibrils and aggregates has been associated with many...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (6): 1177–1196.
Published: 29 March 2018
...Kristen L. Huber; Banyuhay P. Serrano; Jeanne A. Hardy Caspase-9 is a critical factor in the initiation of apoptosis and as a result is tightly regulated by many mechanisms. Caspase-9 contains a Caspase Activation and Recruitment Domain (CARD), which enables caspase-9 to form a tight interaction...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (24): 4065–4074.
Published: 01 December 2017
...Biao Dong; Xiaolu Zhang; Yafeng Fan; Songqiang Cao; Xuepei Zhang The aim of the present study was to investigate the effects and molecular mechanisms of GPR4 (G-protein-coupled receptor 4) in cell apoptosis and renal ischemia–reperfusion (IR) injury in vivo and in vitro . GPR4 −/− mice and wild...
Articles
Richa Dubey, Pooja Minj, Nikita Malik, Devika M. Sardesai, Shruti H. Kulkarni, Jhankar D. Acharya, Neel Sarovar Bhavesh, Shilpy Sharma, Ashutosh Kumar
Journal:
Biochemical Journal
Biochem J (2017) 474 (23): 3915–3934.
Published: 16 November 2017
... (T2DM). The human islet amyloid polypeptide (hIAPP) forms amyloid plaques in the pancreas of T2DM subjects (>95%) that are involved in deteriorating islet function and in mediating β - cell apoptosis. However, the detailed mechanism of action, structure and nature of toxic hIAPP species responsible...
Includes: Supplementary data
Articles
Andrea Fagagnini, Andrea Pica, Sabrina Fasoli, Riccardo Montioli, Massimo Donadelli, Marco Cordani, Elena Butturini, Laura Acquasaliente, Delia Picone, Giovanni Gotte
Journal:
Biochemical Journal
Biochem J (2017) 474 (22): 3767–3781.
Published: 06 November 2017
... by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis cytotoxicity domain swapping onconase protein oligomerization ribonucleases Onconase® (ONC, Alfacell Corporation, Somerset, NJ, U.S.A.), earlier named P30 protein [ 1 ], is a monomeric member of the secretory...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (21): 3643–3657.
Published: 23 October 2017
... © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 apoptosis Bcl-2 hematological malignancy Apoptosis is a highly regulated form of programmed cell death and is crucial for the regulation of many processes including organ development...
Articles
Maria B. Garcia-Fabiani, Mauro A. Montanaro, Pablo Stringa, Ezequiel Lacunza, Elizabeth R. Cattaneo, Marianela Santana, Magali Pellon-Maison, Maria R. Gonzalez-Baro
Journal:
Biochemical Journal
Biochem J (2017) 474 (18): 3093–3107.
Published: 31 August 2017
... by inoculating lentiviral particles carrying the sequence of a short-hairpin RNA targeting Gpat2 mRNA into mouse testis. Histological and gene expression analysis showed impaired spermatogenesis and arrest at the pachytene stage. Defects in reproductive fitness were also observed, and the analysis of apoptosis...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (17): 3027–3043.
Published: 22 August 2017
.... Periplanetasin-2 induced oxidative stress by generation of reactive oxygen species (ROS) and lipid peroxidation. Periplanetasin-2 also caused apoptosis by exposure of phosphatidylserine and fragmentation of DNA, exerted in a concentration-dependent manner. Hence, we investigated the mitochondrial apoptotic...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (17): 3011–3025.
Published: 22 August 2017
... dysplasia led to the inhibition of SCC, thereby reducing the tumor burden. The antioxidant capacity of AN and EG was also brought out via biochemical analysis. Further investigation of biomarkers in tongue tissues revealed the involvement of apoptosis in vivo . Moreover, no adverse or toxic effect...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 2973–2994.
Published: 27 September 2016
... factor for NMSC is ultraviolet radiation (UVR) from sunlight, specifically UVB, which is the leading cause of DNA damage, photoaging, and malignant transformation in the skin. Activation of apoptosis following UVR exposure allows the elimination of irreversibly damaged cells that may harbor oncogenic...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (8): 1073–1083.
Published: 08 April 2016
... by Bcl-2 homology 3 domain (BH3) proteins. Some of the compounds induced Bax/Bak-dependent apoptosis in cells. Activation of Bax by the most active compound was poorly inhibited by the anti-apoptotic protein Bcl-XL and requires a cysteine residue at position 126 of Bax that is not required for activation...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 470 (1): 145–154.
Published: 06 August 2015
...Hsiang Yu; Huey-Jen Lai; Tai-Wei Lin; Chang-Shi Chen; Szecheng J. Lo Three waves of apoptosis shape the development of Caenorhabditis elegans . Although the exact roles of the three DNase II genes ( nuc-1 , crn-6 and crn-7 ), which are known to mediate degradation of apoptotic DNA, in the embryonic...
Includes: Multimedia, Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 469 (2): 315–324.
Published: 06 July 2015
... also induced expression of lipocalin 2 ( Lcn2 ) and other NF-κB (nuclear factor κB)-related genes. siRNA-induced apoptosis was inhibited by Lcn2 repression or NF-κB inhibitors. This is the first report on Pla2g4c gene-deficient rats and their low susceptibility to mammary carcinogenesis by enhancing NF...
Articles
Journal:
Biochemical Journal
Biochem J (2015) 467 (3): 495–505.
Published: 17 April 2015
...Aisha Shamas-Din; Scott Bindner; Xiaoke Chi; Brian Leber; David W. Andrews; Cécile Fradin tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL...
Articles
Paul T. Manna, Tim S. Munsey, Nada Abuarab, Fangfang Li, Aruna Asipu, Gareth Howell, Alicia Sedo, Wei Yang, Jacqui Naylor, David J. Beech, Lin-Hua Jiang, Asipu Sivaprasadarao
Journal:
Biochemical Journal
Biochem J (2015) 466 (3): 537–546.
Published: 06 March 2015
...-ribose, the by-product of NAD metabolism, is a potent activator of the transient receptor potential (melastatin) 2 (TRPM2) channel [ 8 ] and inhibition of TRPM2 channels prevents apoptosis [ 9 – 12 ]. These later results raised the possibility that TRPM2 (ADP-ribose)-mediated β-cell apoptosis could also...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (1): 115–125.
Published: 12 December 2014
... no such effects. The chaperone activities of the peptides were better than those from αA- and αB-crystallin. HeLa cells took up the FITC-conjugated Hsp20 peptide and, when the cells were thermally stressed, the peptide was translocated from the cytoplasm to the nucleus. The two peptides inhibited apoptosis...
Articles
The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1–PKB/Akt signalling
In Collection
Coronavirus
Journal:
Biochemical Journal
Biochem J (2014) 464 (3): 439–447.
Published: 05 December 2014
...Ho Tsoi; Li Li; Zhefan S. Chen; Kwok-Fai Lau; Stephen K. W. Tsui; Ho Yin Edwin Chan A number of viral gene products are capable of inducing apoptosis by interfering with various cellular signalling cascades. We previously reported the pro-apoptotic property of the SARS-CoV (severe acute respiratory...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 462 (3): 489–497.
Published: 22 August 2014
... transgene protects cortical neurons from H 2 O 2 -induced apoptosis, and this protective effect is abrogated by knocking down RACK1. Similarly, deletion of DJ-1 in cortical neurons increases the sensitivity to H 2 O 2 , and the damage can be significantly rescued by DJ-1 or DJ-1/RACK1 co-transfection...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 462 (2): 267–277.
Published: 07 August 2014
... differentiation. During myoblast differentiation, autophagy is mediated by JNK activity through regulation of BECN1–BCL2 association. Inhibition of autophagy impairs myoblast differentiation and increases apoptotic cell death. apoptosis autophagy beclin 1 (BECN1) caspase 3 (CASP3) differentiation...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 459 (3): 513–524.
Published: 11 April 2014
... apoptosis BCL2-interacting killer (BIK) BCL2-interacting mediator of cell death (BIM) cell cycle extracellular-signal-regulated kinase 1/2 (ERK1/2) proteasome The cell intrinsic pathway of apoptosis is controlled by interactions between pro- and anti-apoptotic members of the BCL2 protein family...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 459 (2): 397–404.
Published: 28 March 2014
...Shang H. Lin; Nuval Cherian; Benjamin Wu; Hyo Phee; Christy Cho; Marco Colombini Bax, despite being a cytosolic protein, has the distinct ability to form channels in the mitochondrial outer membrane, which are capable of releasing proteins that initiate the execution phase of apoptosis. When...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 459 (1): 149–160.
Published: 14 March 2014
... cybrids to apoptotic stress. Phosphorylated Akt is involved in the protection of cells by CA8 in MERRF cybrids. apoptosis autophagy carbonic anhydrase-related protein VIII (CA8) mitochondrion mtDNA point mutation myoclonus epilepsy associated with ragged-red fibres (MERRF) Mitochondria...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 458 (2): 259–265.
Published: 14 February 2014
...Tracy M. Josephs; Ian M. Morison; Catherine L. Day; Sigurd M. Wilbanks; Elizabeth C. Ledgerwood The peroxidase activity of cytochrome c may play a key role in the release of cytochrome c from the mitochondrial intermembrane space in the intrinsic apoptosis pathway. Induction of the peroxidase...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 457 (1): 151–162.
Published: 10 December 2013
... shown that miRNAs are extensively involved in the pathogenesis of cardiac hypertrophy. In the present study, we examined the hypothesis that the miR-19a/b family acts as a key regulator of cardiac hypertrophy and apoptosis. Forced overexpression of miR-19a/b was sufficient to induce hypertrophy in rat...
Includes: Supplementary data
Articles
Daouda A. K. Traore, Amelia J. Brennan, Ruby H. P. Law, Con Dogovski, Matthew A. Perugini, Natalya Lukoyanova, Eleanor W. W. Leung, Raymond S. Norton, Jamie A. Lopez, Kylie A. Browne, Hideo Yagita, Gordon J. Lloyd, Annette Ciccone, Sandra Verschoor, Joseph A. Trapani, James C. Whisstock, Ilia Voskoboinik
Journal:
Biochemical Journal
Biochem J (2013) 456 (3): 323–335.
Published: 22 November 2013
.... apoptosis C2 domain cytotoxic lymphocyte perforin pore-forming protein The pore-forming protein, PRF (perforin; PRF1 gene), is stored and secreted by cytotoxic lymphocytes [CTLs (cytotoxic T-lymphocytes) and natural killer cells] and is essential for the successful elimination of virus...
Articles
Fan Yang, Su Chen, Zhong-Min Dai, Dian-Fu Chen, Ru-Bing Duan, Hong-Liang Wang, Sheng-Nan Jia, Wei-Jun Yang
Journal:
Biochemical Journal
Biochem J (2013) 456 (2): 185–194.
Published: 08 November 2013
... of cysts with coarse shells in which two chitin-binding proteins were missing. Western blotting showed that the level of trehalase was increased and apoptosis was induced in these ArTAP-knockdown cysts compared with controls. Taken together, these results show that ArTAP is a key regulator of trehalase...
Includes: Supplementary data
Articles
Qiuli Liang, Gloria A. Benavides, Athanassios Vassilopoulos, David Gius, Victor Darley-Usmar, Jianhua Zhang
Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 249–257.
Published: 09 August 2013
... Biochemical Society 2013 apoptosis autophagy c-Jun c-Jun N-terminal kinase (JNK) sirtuin 3 Autophagy is a highly conserved process that occurs ubiquitously in all eukaryotic cells [ 1 ]. It is an intracellular bulk degradation pathway for delivery of proteins and organelles to lysosomes...
Includes: Supplementary data
Articles
Darius J. R. Lane, Michael Li-Hsuan Huang, Samantha Ting, Sutharshani Sivagurunathan, Des R. Richardson
Journal:
Biochemical Journal
Biochem J (2013) 453 (3): 321–336.
Published: 12 July 2013
... (email d.richardson@med.usyd.edu.au ). 14 1 2013 12 4 2013 15 5 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 apoptosis autophagy cardiomyopathy frataxin Friedreich's ataxia integrated stress response FRDA (Friedreich's ataxia...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 452 (2): 281–291.
Published: 10 May 2013
...Shanshan Li; Yajuan Ran; Dandan Zhang; Jianguo Chen; Shuzhen Li; Daling Zhu Unbalanced apoptosis is a major cause of structural remodelling of vasculatures associated with PAH (pulmonary arterial hypertension), whereas the underlying mechanisms are still elusive. miRNAs (microRNAs) regulate...
Includes: Supplementary data
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