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Keywords: androgens
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Biochem J (2023) 480 (20): 1599–1614.
Published: 13 October 2023
... androgen signalling systems and a variety of other transduction pathways which drive differentiation of these cells towards castration-resistance. One such signalling pathway is the ubiquitous cAMP signalling axis which functions to activate spatially restricted pools of cAMP effectors such as protein...
Biochem J (2019) 476 (21): 3313–3331.
Published: 11 November 2019
... Hospital, University of Toronto, Toronto, ON, Canada © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 androgens cytochrome p450 enzyme activity estrogens mass spectrometry The enzyme aromatase (AROM; CYP19A1 ), an integral membrane...
Includes: Supplementary data
Biochem J (2018) 475 (1): 75–85.
Published: 02 January 2018
... in steroidogenesis has recently been challenged by the development of TSPO knockout (TSPO-KO) mice, as they exhibit normal baseline gonadal testosterone and adrenal corticosteroid production. Here, we demonstrate that despite normal androgen levels in young male TSPO-KO mice, TSPO deficiency alters steroidogenic...