... in infected persons [ 3–6 ]. Nef has therefore been suggested to be a promising drug target. 18-crown-6 allostery autoinhibition selectivity tertiary recognition thermodynamics In a second round of crystallization experiments, Fyn R96I with a C-terminal hexahistidine tag (see [ 46...

... for this article was enabled by the participation of The Francis Crick Institute in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. allostery drug screening HER3 inhibitor pseudokinases Pseudokinases belong...

... ) * These authors made equal contributions. 26 11 2019 18 3 2020 23 3 2020 23 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 allostery biphasic protein-tyrosine kinases signaling ZAP-70 The zeta-chain...

... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . allostery HtrA3 activation HtrA3 mutants molecular dynamics PDZ serine protease domain High-temperature...

... Biology, Academia Sinica, Taipei City, 115, Taiwan 8 8 2019 18 9 2019 23 9 2019 23 9 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 ab initio allostery fluorescence quenching HAX-1 HtrA2 limited...

...@actrec.gov.in ) * The author is deceased and is contributing posthumously. 20 3 2019 23 4 2019 26 4 2019 29 4 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 allostery apoptosis enzyme kinetics HtrA4 serine...

...Nandakumar Rajasekaran; Athi N. Naganathan Elucidating the extent of energetic coupling between residues in single-domain proteins, which is a fundamental determinant of allostery, information transfer and folding cooperativity, has remained a grand challenge. While several sequence- and structure...

... of fructose-6-phosphate (F6P). allostery cancer co-operativity glycolysis kinase Tarui's disease 6-Phosphofructokinase (Pfk; EC 2.7.1.11), is the main regulator of glycolysis and catalyses the Mg-ATP-dependent formation of fructose-1,6-bisphosphate (F16BP) from fructose-6-phosphate (F6P...

... for treating many diseases. We show that commonly used integrin inhibitors are unable to dissociate pre-formed integrin–ligand complexes, whereas inhibitors that function allosterically are able to do so. allostery antagonist fibronectin integrin RGD motif therapeutics Integrins are a large...

... initiation. 1 To whom correspondence should be addressed (email ruthnu@helix.nih.gov ). 1 6 2011 23 6 2011 28 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 allosteric pathway allosteric propagation allostery enhancer mediator...

... Data Bank under accession code 2AFQ. 27 7 2005 15 9 2005 4 10 2005 4 10 2005 The Biochemical Society, London 2005 allostery crystal structure haemostasis slow thrombin sodium 1 To whom correspondence should be addressed (email jah52@cam.ac.uk...

... mechanistic interpretations. Such a controversy has arisen over thrombin's conformational response to Na + co-ordination, and in this issue of Biochemical Journal , De Filippis and colleagues put the two structural models of thrombin allostery to the test by returning to the techniques of solution...

... The Biochemical Society, London 2005 allostery coagulation hirudin limited proteolysis Na + thrombin Hirudin analogues were synthesized, allowed to refold and purified as described previously [ 18 , 19 ]. The inhibitory potency of the synthetic analogues was determined by measuring...

... conformation and hence ligand affinity. 1 To whom correspondence should be addressed (e-mail rlidding@burnham.org ). 12 8 2002 27 2 2003 3 3 2003 3 3 2003 The Biochemical Society, London ©2003 2003 A domain allostery gain-of-function I domain integrin...