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Keywords: adaptor protein 3 (AP-3) complex
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Biochem J (2014) 464 (1): 145–156.
Published: 23 October 2014
... phosphorylates two distinct sites in the N-terminus of PI4KIIα (Ser 5 and Ser 47 ), promoting binding to the adaptor protein 3 (AP-3) complex for trafficking to the lysosome to be degraded. Blocking phosphorylation reduces trafficking to the lysosome, stabilizing PI4KIIα and its cargo proteins for redistribution...