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Keywords: activation loop
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Biochem J (2014) 459 (1): 59–69.
Published: 14 March 2014
... is potently inhibited by this drug [ 7 ]. Activation of kinases frequently occurs via phosphorylation of the activation loop, also called the T-loop, a stretch of usually 30–40 amino acids that is located between two conserved motifs found in kinases: the DFG (Asp/Phe/Gly) and APE (Ala/Pro/Glu) motifs...
Includes: Supplementary data
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Biochem J (2013) 454 (1): 39–47.
Published: 26 July 2013
... of the activation loop. © The Authors Journal compilation © 2013 Biochemical Society 2013 activation loop hydrophobic motif mammalian target of rapamycin (mTOR) signalling phosphorylation ribosomal protein subunit 6 kinase 1 (S6K1) zinc finger 1 To whom correspondence should be addressed...
Includes: Supplementary data
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Biochem J (2006) 394 (3): e7.
Published: 24 February 2006
... 31 1 2006 2 2 2006 The Biochemical Society, London 2006 A common feature of the AMPK-related kinases is conservation of the activation loop (T-loop) threonine residue (Thr-172 in α1/α2-AMPK) located in a distinct motif between subdomains VII and VIII of the kinase domain. AMPK Thr...
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