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Keywords: X-ray structure
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Biochem J (2020) 477 (1): 275–284.
Published: 17 January 2020
... tapped and then spun for 1 min at 1000 rpm at RT. Plate was then sealed and incubated for 90 min at RT in the dark. Plates were then read on a BMG PHERAstar FSX (Ex.340, Em. 490/520, fly mode). GCN2 kinase x-ray structure GCN2, general control nonderepressible 2 kinase, is one of four...
Includes: Supplementary data
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Biochem J (2017) 474 (15): 2601–2617.
Published: 21 July 2017
... replacement, using as a search model PDB ID: 3UF2. A summary of the diffraction data collection statistics is given in Supplementary Table S1. Figure 1. Structure of the M-CSF C31S mutant, compared with the M-CSF wild-type structure. ( A ) X-ray structure of the dimeric M-CSF C31S mutant solved here...
Includes: Supplementary data
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Biochem J (2016) 473 (14): 2109–2118.
Published: 12 July 2016
.... Protein unfolding was followed by the increase in the fluorescence values given by the SYPRO Orange probe. Different buffer effects were analysed in the pH range of 3–10. carbohydrate-binding domain Clostridium perfringens protein–glycan interactions sialic acid X-ray structure...
Includes: Supplementary data
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Biochem J (2016) 473 (10): 1329–1341.
Published: 11 May 2016
... for enhanced binding affinity [ 33 – 35 ], proper folding [ 36 , 37 ] and improved thermal stability [ 38 ]. cancer therapy directed evolution enzyme inhibition mesotrypsin protease inhibitor protein engineering proteolysis X-ray structure The human serine protease mesotrypsin, encoded...
Includes: Supplementary data
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Biochem J (2014) 458 (3): 525–536.
Published: 28 February 2014
... ]. conformational dynamics FK506-binding protein 12 (FKBP12) linebroadening analysis NMR slow exchange X-ray structure The peptide prolyl isomerase FKBP12 (FK506-binding protein 12) was initially characterized for its role in binding the immunosuppressants FK506 and rapamycin. The ternary complex...
Includes: Supplementary data
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Biochem J (2013) 456 (1): 81–88.
Published: 24 October 2013
... and closed conformations and probe the reaction mechanism through the binding of transition state mimics. We confirm that the nucleophilic attack occurs on the β-phosphate. deoxyuridine triphosphate nucleotidohydrolase (dUTPase) mechanism nucleotide binding Trypanosoma X-ray structure...
Includes: Supplementary data
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Biochem J (2013) 453 (3): 371–380.
Published: 12 July 2013
... isomerization. Many of the residues exhibiting resonance doubling also participate in conformational line-broadening transition(s) that occur ~10 5 -fold more rapidly, proposed previously to arise from a single global process. The 1.70 Å (1 Å=0.1 nm) resolution X-ray structure of the H87V variant is strikingly...
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Biochem J (2013) 449 (1): 51–60.
Published: 07 December 2012
... 17.9 173 2.01 2WQT 2.80 – – – catalytic lid domain Cg1458 fumarylacetoacetate hydrolase glutamic acid–histidine–water triad X-ray structure OADs [OAA (oxaloacetate) decarboxylase; EC 4.1.1.3] catalyse the decarboxylation of OAA to pyruvate and CO 2 . There are two...
Includes: Supplementary data
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Biochem J (2012) 445 (2): 175–182.
Published: 27 June 2012
...Winfried Meining; Arne Skerra We describe the 2.3 Å (1 Å=0.1 nm) X-ray structure of α 1 m (α 1 -microglobulin), an abundant protein in human blood plasma, which reveals the β-barrel fold typical for lipocalins with a deep pocket lined by four loops at its open rim. Loop #1 harbours the residue Cys...
Includes: Supplementary data
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Biochem J (2012) 442 (3): 483–494.
Published: 24 February 2012
... hepsin antibody induced conformational change prostate cancer transmembrane serine protease X-ray structure chH35 (chimaeric hepsin antibody) was transiently expressed in HEK (human embryonic kidney)-293 cells by transfection of the light- and heavy-chain plasmids via lipofection. Supernatant...
Includes: Supplementary data
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Biochem J (2009) 420 (1): 17–25.
Published: 28 April 2009
...) and 50 mM DTT]. The hanging drops were equilibrated against 1 ml of reservoir solution and placed at room temperature in the dark. acute intermittent porphyria dipyrromethane haem human porphobilinogen deaminase X-ray structure PBGD (porphobilinogen deaminase; EC 4.3.4.8, also...
Includes: Supplementary data
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