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Keywords: Trypanosoma cruzi
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Articles
Biochem J (2021) 478 (21): 3891–3903.
Published: 09 November 2021
...Brian S. Mantilla; Lisvane Paes-Vieira; Felipe de Almeida Dias; Simone G. Calderano; Maria Carolina Elias; Daniela Cosentino-Gomes; Pedro L. Oliveira; José Roberto Meyer-Fernandes; Ariel M. Silber The pathogenic protist Trypanosoma cruzi uses kissing bugs as invertebrate hosts that vectorize...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (10): 1827–1845.
Published: 21 May 2020
...Letícia Marchese; Karel Olavarria; Brian Suarez Mantilla; Carla Cristi Avila; Rodolpho Ornitiz Oliveira Souza; Flávia Silva Damasceno; Maria Carolina Elias; Ariel Mariano Silber In Trypanosoma cruzi , the etiological agent of Chagas disease, the amino acid proline participates in processes related...
Includes: Supplementary data
Articles
Biochem J (2019) 476 (2): 179–191.
Published: 18 January 2019
... phosphofructokinase reverse reaction Trypanosoma cruzi Trypanosoma brucei Phosphofructokinase (PFK) catalyses the phosphorylation of fructose 6-phosphate (F6P) to fructose 1,6-bisphosphate (F1,6BP) and plays a central role in the glycolytic pathway of prokaryotes and eukaryotes. The enzymatic step...
Includes: Supplementary data
Articles
Biochem J (2018) 475 (7): 1235–1251.
Published: 05 April 2018
...Damián Estrada; Gabriela Specker; Alejandra Martínez; Patricia Pereira Dias; Barbara Hissa; Luciana O. Andrade; Rafael Radi; Lucía Piacenza Chagas disease (CD), caused by the protozoa Trypanosoma cruzi , is a chronic illness in which parasites persist in the host-infected tissues for years. T...
Includes: Supplementary data
Articles
Biochem J (2014) 459 (2): 323–332.
Published: 28 March 2014
... pharmacologically validated as a drug target in the African trypanosome, Trypanosoma brucei . In the present study, we evaluate NMT as a potential drug target in Trypanosoma cruzi , the causative agent of Chagas’ disease, using chemical and genetic approaches. Replacement of both allelic copies of TcNMT ( T. cruzi...
Articles
Biochem J (2013) 452 (3): 423–432.
Published: 31 May 2013
...Radika Soysa; Hanka Venselaar; Jacqueline Poston; Buddy Ullman; Marie-Pierre Hasne The TcPOT1.1 gene from Trypanosoma cruzi encodes a high affinity putrescine-cadaverine transporter belonging to the APC (amino acid/polyamine/organocation) transporter superfamily. No experimental three-dimensional...
Includes: Supplementary data
Articles
Biochem J (2013) 451 (2): 257–267.
Published: 28 March 2013
..., this protein is modified by phosphorylation with unknown functions. In the present study we show that a phosphorylated state of eIF5A predominates in exponentially growing Trypanosoma cruzi cells, and extensive dephosphorylation occurs in cells in stationary phase. Phosphorylation occurs mainly at Ser 2...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (2): 211–218.
Published: 11 May 2012
...Gaspar E. Cánepa; Maria Sol Degese; Alexandre Budu; Celia R. S. Garcia; Carlos A. Buscaglia TSSA (trypomastigote small surface antigen) is a polymorphic mucin-like molecule displayed on the surface of Trypanosoma cruzi trypomastigote forms. To evaluate its functional properties, we undertook...
Includes: Supplementary data
Articles
Biochem J (2011) 438 (2): 303–313.
Published: 12 August 2011
...Ivana Urban; Lucía Boiani Santurio; Agustina Chidichimo; Hai Yu; Xi Chen; Juan Mucci; Fernán Agüero; Carlos A. Buscaglia The surface of the protozoan Trypanosoma cruzi is covered by a dense coat of mucin-type glycoconjugates, which make a pivotal contribution to parasite protection and host immune...
Includes: Supplementary data
Articles
Biochem J (2010) 429 (3): 533–543.
Published: 14 July 2010
... supply of nucleotide-sugars (NDP-sugars), yet little is known about how these NDP-sugars are made and supplied. In the present paper, we report a functional gene from Trypanosoma cruzi that encodes a nucleotidyltransferase, which is capable of transforming different types of sugar 1-phosphates and NTP...
Includes: Supplementary data
Articles
Biochem J (2009) 424 (3): 479–490.
Published: 10 December 2009
...Sara R. Heras; M. Carmen Thomas; Francisco Macias; Manuel E. Patarroyo; Carlos Alonso; Manuel C. López It has been reported previously that the C2-L1Tc protein located in the Trypanosoma cruzi LINE (long interspersed nuclear element) L1Tc 3′ terminal end has NAC (nucleic acid chaperone) activity...
Articles
Biochem J (2009) 418 (3): 595–604.
Published: 25 February 2009
...Florencia Irigoín; Natalia M. Inada; Mariana P. Fernandes; Lucía Piacenza; Fernanda R. Gadelha; Anibal E. Vercesi; Rafael Radi The epimastigote stage of Trypanosoma cruzi undergoes PCD (programmed cell death) when exposed to FHS (fresh human serum). Although it has been known for over 30 years...
Includes: Supplementary data
Articles
Biochem J (2008) 410 (2): 359–368.
Published: 12 February 2008
...Lucía Piacenza; Gonzalo Peluffo; María Noel Alvarez; John M. Kelly; Shane R. Wilkinson; Rafael Radi There is increasing evidence that Trypanosoma cruzi antioxidant enzymes play a key immune evasion role by protecting the parasite against macrophage-derived reactive oxygen and nitrogen species...
Includes: Supplementary data
Articles
Biochem J (2007) 403 (2): 323–334.
Published: 26 March 2007
...Lucía Piacenza; Florencia Irigoín; María Noel Alvarez; Gonzalo Peluffo; Martin C. Taylor; John M. Kelly; Shane R. Wilkinson; Rafael Radi Trypanosoma cruzi undergo PCD (programmed cell death) under appropriate stimuli, the mechanisms of which remain to be established. In the present study, we show...
Includes: Supplementary data
Articles
Biochem J (2007) 401 (2): 399–410.
Published: 21 December 2006
... eukaryotic genomes, with the remarkable exception of those of trypanosomatids. The genome of the CL Brener clone of Trypanosoma cruzi , the causative agent of Chagas' disease, encodes two such MCPs, with 64% identity between them: Tc MCP-1 and Tc MCP-2. Both genes, which are present in a single copy per...
Includes: Supplementary data
Articles
Biochem J (2007) 401 (1): 279–285.
Published: 11 December 2006
...Ana L. Stern; Emmanuel Burgos; Laurent Salmon; Juan J. Cazzulo Trypanosoma cruzi , the human parasite that causes Chagas disease, contains a functional pentose phosphate pathway, probably essential for protection against oxidative stress and also for R5P (ribose 5-phosphate) production...
Articles
Biochem J (2006) 399 (2): 305–314.
Published: 27 September 2006
...Rocío Díaz-Benjumea; Sunil Laxman; Thomas R. Hinds; Joseph A. Beavo; Ana Rascón Trypanosoma cruzi , the causative agent of Chagas disease, encodes a number of different cAMP-specific PDE (phosphodiesterase) families. Here we report the identification and characterization of TcrPDEB1 and its...
Includes: Supplementary data
Articles
Biochem J (2005) 392 (3): 467–474.
Published: 06 December 2005
...Mauricio Vieira; Peter Rohloff; Shuhong Luo; Narcisa L. Cunha-E-Silva; Wanderley De Souza; Roberto Docampo Previous studies in Trypanosoma cruzi , the etiologic agent of Chagas disease, have resulted in the cloning and sequencing of a pair of tandemly linked genes ( TcHA1 and TcHA2 ) that encode P...
Articles
Biochem J (2005) 388 (1): 29–38.
Published: 10 May 2005
... of Trypanosoma cruzi ) is involved in the process of cell invasion, since specific inhibitors block parasite entry into non-phagocytic mammalian host cells. In contrast with other POPs, POP Tc80 is capable of hydrolysing large substrates, such as fibronectin and native collagen. In this study, we present...
Includes: Supplementary data
Articles
Biochem J (2005) 387 (2): 519–529.
Published: 05 April 2005
... other lower eukaryotes, the protozoan parasite Trypanosoma cruzi is capable of synthesizing free or protein-linked glycoinositolphospholipids containing IPC. As a first step towards understanding the importance and mechanism of IPC synthesis in T. cruzi , we investigated the effects of rustmicin...
Includes: Supplementary data
Articles
Biochem J (2004) 381 (3): 743–752.
Published: 27 July 2004
...Nisha GARG; Arpad GERSTNER; Vandanajay BHATIA; James DeFORD; John PAPACONSTANTINOU Cardiac hypertrophy and remodelling in chagasic disease might be associated with mitochondrial dysfunction. In the present study, we characterized the cardiac metabolic responses to Trypanosoma cruzi infection...
Articles
Biochem J (2004) 378 (1): 63–72.
Published: 15 February 2004
... localization of TcPDE1, the first cAMP-specific phosphodiesterase to be identified from Trypanosoma cruzi . TcPDE1 is part of a small gene family and encodes a 929-amino-acid protein that can complement a heat-shock-sensitive yeast mutant deficient in phospho-diesterase genes. Recombinant TcPDE1 strongly...
Articles
Biochem J (2000) 352 (3): 755–761.
Published: 08 December 2000
... trypanosome Trypanosoma cruzi . We have isolated a single-copy gene from T. cruzi with the potential to encode an 18kDa enzyme, the sequence of which has highest similarity with glutathione peroxidases from plants. A recombinant form of the protein was purified following expression in Escherichia coli...