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Keywords: Trypanosoma
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Biochem J (2013) 456 (1): 81–88.
Published: 24 October 2013
...Glyn R. Hemsworth; Dolores González-Pacanowska; Keith S. Wilson The Tritryps Trypanosoma brucei , Trypanosoma cruzi and Leishmania donovani are responsible for great morbidity and mortality in developing countries. Their dimeric dUTPases are members of the all-α NTP pyrophosphohydrolase family...
Includes: Supplementary data
Articles
Biochem J (2011) 438 (2): 229–244.
Published: 12 August 2011
... to the clinical treatment of West African sleeping sickness caused by Trypanosoma brucei gambiense and has prompted the notion that polyamine homoeostasis may also be an important drug target in the other major protozoan parasites of human importance. These include the trypanosomatids Trypanosoma cruzi...
Includes: Multimedia, Supplementary data
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Biochem J (2008) 414 (3): 375–381.
Published: 27 August 2008
...Magnus S. Alphey; Janine König; Alan H. Fairlamb Tb TDPX ( Trypanosoma brucei tryparedoxin-dependent peroxidase) is a genetically validated drug target in the fight against African sleeping sickness. Despite its similarity to members of the GPX (glutathione peroxidase) family, Tb TDPX2...
Includes: Supplementary data
Articles
Biochem J (2007) 401 (2): e5.
Published: 21 December 2006
...Neil D. Rawlings Eukaryote homologues of carboxypeptidases Taq have been discovered by Niemirowicz et al. in the protozoan Trypanosoma cruzi , the causative agent of Chagas' disease. This is surprising, because the peptidase family was thought to be restricted to bacteria and archaea. In this issue...
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Biochem J (2006) 396 (2): 287–295.
Published: 15 May 2006
... of GPI anchors has previously been validated both genetically and chemically as a drug target in Trypanosoma brucei , the causative parasite of African sleeping sickness. However, nothing is known about the synthesis of PI in this organism. Database mining revealed a putative TbPIS gene in the T. brucei...
Includes: Supplementary data
Articles