... 4.0 (CC BY) . colorectal cancer cells IKKβ IL-1 NF-κB TNF The nuclear factor-κB (NF-κB) transcription factors (homo- and hetero-dimers of p65/RelA, RelB, c-Rel, NF-κB1/p50 and NF-κB2/p52) are sequestered in the cytoplasm through their binding to inhibitor of kappa B (IκB) proteins...

... neutral sphingomyelinase activity is involved in TNFa signalling. Key words: caveolae, ceramide, fibroblast, Niemann Pick dis- ease, TNF. caveolin-1 )# ) provides a mechanistic basis for this hypothesis. This cytoplasmic 20-amino acid region of caveolin is envisaged to interact directly with caveolae...