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Keywords: Saccharomyces cerevisiae
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Biochem J (2023) 480 (20): 1639–1657.
Published: 18 October 2023
... and muscle cells. Although the mechanistic studies of mitophagy in mammalian cells were initiated after the initial mechanistic findings in Saccharomyces cerevisiae , our current understanding of the physiological role of mitophagy in yeast remains more limited, despite the presence of better-defined assays...
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Biochem J (2021) 478 (24): 4153–4167.
Published: 16 December 2021
... that sHSPs may be universally conserved effectors of longevity. aging mitochondria molecular chaperones Saccharomyces cerevisiae Analysis and visualisation of genetic and protein interactions within the proteomic data was performed with the open-source software Cytoscape ( https...
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Biochem J (2020) 477 (18): 3613–3623.
Published: 28 September 2020
...Pierre Voisin; Marianne Bernard; Thierry Bergès; Matthieu Régnacq Lipid droplets are ubiquitous organelles in eukaryotes that act as storage sites for neutral lipids. Under normal growth conditions, they are not required in the yeast Saccharomyces cerevisiae . However, recent works have shown...
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Biochem J (2019) 476 (1): 151–164.
Published: 15 January 2019
... explored. Overexpressing LACS has been shown to increase the production of fatty acid esters, fatty alcohols, waxes and TAGs in Escherichia coli and yeast ( Saccharomyces cerevisiae ). For example, metabolic engineering of E. coli to produce fatty acid esters, fatty alcohols and waxes was achieved...
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Biochem J (2018) 475 (17): 2831–2845.
Published: 11 September 2018
...: Cheol-Won Yun ( cheolwony@korea.ac.kr ) Saccharomyces cerevisiae has been used to study iron and copper metabolism. In S. cerevisiae , reduced transition metals from the environment are transported into cytoplasmic compartments by metal-specific transporters [ 5 – 7 ]. Both reductive and non...
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Biochem J (2017) 474 (20): 3439–3454.
Published: 05 October 2017
... of TorA, the biological function of TorA remains to be established. Here, we use the yeast Saccharomyces cerevisiae as a tractable in vivo model to explore TorA function. We demonstrate that TorA can protect yeast cells against different forms of environmental stress and show that in the absence...
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Biochem J (2017) 474 (11): 1807–1821.
Published: 16 May 2017
... and the suitability of these strategic approaches for identifying such residues are discussed. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 oligopeptide transporter family Saccharomyces cerevisiae site-directed mutagenesis transmembrane proteins...
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Biochem J (2017) 474 (1): 51–63.
Published: 22 December 2016
... 2016 1 11 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 contact site ER stress lipid asymmetry plasma membrane Rim101 pathway Saccharomyces cerevisiae Living organisms must respond appropriately to environmental...
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Biochem J (2016) 473 (19): 3065–3079.
Published: 27 September 2016
... 29 7 2016 1 8 2016 1 8 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 Hot1 Saccharomyces cerevisiae Spt4/5 Sub1 tandem affinity purification transcription To analyze Hot1, Sub1, Spt5 or Yra1 binding...
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Biochem J (2016) 473 (15): 2369–2382.
Published: 28 July 2016
...Mohammad Zulkifli; Shambhu Yadav; Anil Thakur; Shiffalli Singla; Monika Sharma; Anand Kumar Bachhawat The high-affinity glutathione transporter Hgt1p of Saccharomyces cerevisiae belongs to a relatively new and structurally uncharacterized oligopeptide transporter (OPT) family. To understand...
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Biochem J (2016) 473 (9): 1203–1213.
Published: 26 April 2016
... are putative virulence factors of A. fumigatus ; sit1 and sit2 are homologous to yeast Sit1, and sit1 and sit2 gene expression was up-regulated after iron depletion. When expressed heterologously in Saccharomyces cerevisiae , sit1 and sit2 were localized to the plasma membrane ; sit1 efficiently complemented...
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Biochem J (2015) 466 (3): 547–559.
Published: 06 March 2015
...), an essential process for overcoming starvation. In Saccharomyces cerevisiae , sensing amino acid shortages requires that Gcn2 binds directly to its effector protein Gcn1 and both must associate with the ribosome. Our hypothesis is that uncharged tRNAs occur in the ribosomal A-site and that Gcn1 is directly...
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Biochem J (2015) 466 (2): 283–290.
Published: 20 February 2015
... (SlTPS1), have demonstrated TPS activity in in vitro assays of the purified or recombinant protein or by complementation studies in a yeast ( Saccharomyces cerevisiae ) tps1 ∆ mutant. This mutant fails to synthesize Tre6P, thereby deregulating the initial part of glycolysis and causing growth arrest...
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Biochem J (2014) 462 (1): 185–197.
Published: 24 July 2014
... membrane-bound proton-translocating V o complex. This nutrient-dependent phenomenon had been first detected in the midgut epithelium of non-feeding moulting tobacco hornworms ( Manduca sexta ) and in glucose-deprived yeast cells ( Saccharomyces cerevisiae ). Since reversible disassembly to date had been...
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Biochem J (2012) 443 (3): 663–670.
Published: 16 April 2012
... between Saccharomyces cerevisiae Nth1 and 14-3-3 protein isoforms Bmh1 and Bmh2. We determined four residues that are phosphorylated by PKA (protein kinase A) in vitro within the disordered N-terminal segment of Nth1. Sedimentation analysis and enzyme kinetics measurements show that both yeast 14-3-3...
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Biochem J (2012) 442 (2): 357–368.
Published: 13 February 2012
...J. Albert Abrie; Asier González; Erick Strauss; Joaquín Ariño The Saccharomyces cerevisiae Hal3 protein is a moonlighting protein, able to function both as an inhibitory subunit of the Ppz1 protein phosphatase and as a constituent protomer of an unprecedented heterotrimeric PPCDC...
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Biochem J (2012) 441 (1): 487–498.
Published: 14 December 2011
... to six rounds of directed evolution, achieving a level of secretion in Saccharomyces cerevisiae (21 mg/l) as yet unseen for any ligninolytic peroxidase. The evolved variant for expression harboured four mutations and increased its total VP activity 129-fold. The signal leader processing by the STE13...
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Biochem J (2012) 441 (1): 255–264.
Published: 14 December 2011
.... 1 To whom correspondence should be addressed (email rserrano@ibmcp.upv.es ). 14 7 2011 12 9 2011 15 9 2011 15 9 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 pH homoeostasis signal transduction Gcn2 Saccharomyces cerevisiae amino...
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Biochem J (2011) 438 (3): 523–533.
Published: 26 August 2011
...Carlos Casado; Asier González; Maria Platara; Amparo Ruiz; Joaquín Ariño Exposure of Saccharomyces cerevisiae to alkaline pH provokes a stress condition that generates a compensatory reaction. In the present study we examined a possible role for the PKA (protein kinase A) pathway in this response...
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Biochem J (2011) 435 (1): 259–266.
Published: 15 March 2011
...Yi-Hsuan Wu; Avery G. Frey; David J. Eide The Msc2 and Zrg17 proteins of Saccharomyces cerevisiae are members of the cation diffusion facilitator family of zinc transporters. These proteins form heteromeric complexes that transport zinc into the ER (endoplasmic reticulum). Previous studies...
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Biochem J (2010) 432 (3): 595–608.
Published: 25 November 2010
...María Guirola; Lina Barreto; Ayelen Pagani; Miriam Romagosa; Antonio Casamayor; Silvia Atrian; Joaquín Ariño The Saccharomyces cerevisiae gene PIF1 encodes a conserved eukaryotic DNA helicase required for both mitochondrial and nuclear DNA integrity. Our previous work revealed that a pif1 Δ strain...
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Biochem J (2010) 432 (3): 445–454.
Published: 25 November 2010
... pyridoxal 5-phosphate synthase Saccharomyces cerevisiae site-directed mutagenesis The active form of vitamin B6, PLP (pyridoxal 5-phosphate), is an essential cofactor for numerous metabolic enzymes. PLP also has an important role in amino acid and carbohydrate metabolism [ 1 , 2 ]. To date, two...
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Biochem J (2010) 426 (2): 205–217.
Published: 09 February 2010
... oligosaccharide mannosyltransferase protein N-glycosylation Saccharomyces cerevisiae The pathway of N-linked protein glycosylation in eukaryotes is highly conserved and starts with the assembly of the common core oligosaccharide donor Glc 3 Man 9 GlcNAc 2 -PP-Dol, the glycan moiety of which...
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Biochem J (2009) 424 (1): 61–67.
Published: 23 October 2009
... that conditions of ER (endoplasmic reticulum) stress stimulate LD formation in Saccharomyces cerevisiae . We found that LDs accumulated in yeast mutants with compromised protein glycosylation or ER-associated protein degradation. Moreover, tunicamycin and Brefeldin A, agents which induce ER stress, were found...
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Biochem J (2008) 416 (3): 365–374.
Published: 26 November 2008
...Aparna K. Sapra; Piyush Khandelia; Usha Vijayraghavan Saccharomyces cerevisiae PRP17 -null mutants are temperature-sensitive for growth. In vitro splicing with extracts lacking Prp17 are kinetically slow for the first step of splicing and are arrested for the second step at temperatures greater...
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Biochem J (2008) 415 (3): 455–466.
Published: 15 October 2008
... and signalling from the cell surface. A proteome-wide screen performed in Saccharomyces cerevisiae revealed that Ypp1 interacts physically with the plasma-membrane-associated phosphoinositide 4-kinase, Stt4. In the present study, we demonstrate that phenotypes of ypp1 and stt4 conditional mutants are identical...
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Biochem J (2008) 415 (2): 233–239.
Published: 25 September 2008
... (hexokinase 2) from Saccharomyces cerevisiae . In fact, it has been previously described that expression of GK β in yeast could replace Hxk2 in the glucose signalling pathway of S. cerevisiae . In the present study we report that GK β exerts its regulatory role by association with the yeast transcriptional...
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Biochem J (2008) 409 (3): 651–656.
Published: 15 January 2008
... topoisomerase I in the presence of camptothecin on a repeated trinucleotide sequence, (TTA) 35 , lying in chromosome XIII of Saccharomyces cerevisiae , we can conclude that nucleosomes represent a physical barrier for the enzyme activity. 1 To whom correspondence should be addressed (email...
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Biochem J (2008) 409 (2): 399–406.
Published: 21 December 2007
...Tomokazu Ito; Hisashi Hemmi; Kunishige Kataoka; Yukio Mukai; Tohru Yoshimura YGL196W of Saccharomyces cerevisiae encodes a putative protein that is unidentified but is predicted to have a motif similar to that of the N-terminal domain of the bacterial alanine racemase. In the present study we found...
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