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Keywords: STAT1 phosphorylation
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Biochem J (2022) 479 (3): 385–399.
Published: 11 February 2022
...-regulates IFN-γ signaling in melanoma cells through APLNR mediated β-arrestin 1 but not β-arrestin 2 recruitment. Our data suggests that β-arrestin 1 directly interacts with STAT1 to inhibit STAT1 phosphorylation to attenuate IFN-γ signaling. The APLNR mutant receptor, I109A, which is deficient in β...
Includes: Supplementary data