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Keywords: SLC6A14
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Articles

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Bradley K. Schniers, Mitchell S. Wachtel, Meenu Sharma, Ksenija Korac, Devaraja Rajasekaran, Shengping Yang, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia
Journal: Biochemical Journal
Biochem J (2022) 479 (5): 719–730.
https://doi.org/10.1042/BCJ20210855
Published: 16 March 2022
... demand for sugars, amino acids, and lipids and therefore up-regulate various nutrient transporters to meet this demand. In PDAC, SLC6A14 (an amino acid transporter (AAT)) is up-regulated, affecting overall patient survival. Previously we have shown using in vitro cell culture models and in vivo xenograft...
View article titled, Deletion of <span class="search-highlight">Slc6a14</span> reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer
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Articles

Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1 H-NMR-based metabolomic study in pancreatic cancer cells

Aimin Cai, Hailun Zheng, Zhiwei Chen, Xinlu Lin, Chen Li, Qing yao, Yangzom D. Bhutia, Vadivel Ganapathy, Ruijie Chen, Longfa Kou
Journal: Biochemical Journal
Biochem J (2020) 477 (10): 1923–1937.
https://doi.org/10.1042/BCJ20200275
Published: 29 May 2020
... with gemcitabine. It is well-known that cancer cells reprogram cellular metabolism, coupled with the up-regulation of selective nutrient transporters to feed into the altered metabolic pathways. Our previous studies have demonstrated that the amino acid transporter SLC6A14 is markedly up-regulated in pancreatic...
View article titled, Synergism between <span class="search-highlight">SLC6A14</span> blockade and gemcitabine in pancreactic cancer: a 1 H-NMR-based metabolomic study in pancreatic cancer cells
Open the PDF for Synergism between <span class="search-highlight">SLC6A14</span> blockade and gemcitabine in pancreactic cancer: a 1 H-NMR-based metabolomic study in pancreatic cancer cells in another window
Includes: Supplementary data