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Keywords: Ras
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Articles
Biochem J (2023) 480 (9): 587–605.
Published: 04 May 2023
... effects of ERK1/2 and the therapeutic use of ERKi. In a range of human cancers activating mutations in receptor tyrosine kinases (RTKs), RAS, BRAF and more rarely CRAF and MEK1/2 results in de-regulated ERK1/2 activation [ 10 ] that drives the acquisition and maintenance of key cancer hallmarks. Small...
Includes: Supplementary data
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Biochem J (2020) 477 (15): 2893–2919.
Published: 14 August 2020
...Walaa E. Kattan; John F. Hancock The three human RAS proteins are mutated and constitutively activated in ∼20% of cancers leading to cell growth and proliferation. For the past three decades, many attempts have been made to inhibit these proteins with little success. Recently; however, multiple...
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Biochem J (2018) 475 (3): 643–648.
Published: 14 February 2018
...Robert R. Kay; Thomas D. Williams; Peggy Paschke In a role distinct from and perhaps more ancient than that in signal transduction, PIP3 and Ras help to spatially organize the actin cytoskeleton into macropinocytic cups. These large endocytic structures are extended by actin polymerization from...
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Biochem J (2016) 473 (6): 769–777.
Published: 10 March 2016
...Seiji Torii; Ryosuke Shintoku; Chisato Kubota; Makoto Yaegashi; Ryoko Torii; Masaya Sasaki; Toshinobu Suzuki; Masanobu Mori; Yuhei Yoshimoto; Toshiyuki Takeuchi; Keiichi Yamada Pharmacological challenges to oncogenic Ras-expressing cancer cells have shown a novel type of cell death, ferroptosis...
Includes: Supplementary data
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Biochem J (2013) 452 (2): 313–320.
Published: 10 May 2013
..., but less is known about the role of WT (wild-type) Ras alleles and isoforms in cancer. We used zinc-finger nucleases targeting HRas and NRas to modify both alleles of these genes in the mutant KRas-driven Hec1A endometrial cancer cell line, which normally expresses WT copies of these genes. The disruption...
Includes: Supplementary data
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Biochem J (2013) 450 (2): 285–294.
Published: 15 February 2013
... survival of colorectal cancer and melanoma cell lines with BRAF V600E or RAS mutations. This cell death absolutely required BAX (BCL2-associated X protein) and was inhibited by RNAi (RNA interference)-mediated knockdown of BIM (BCL2-interacting mediator of cell death) in the BRAF V600E -positive COLO205...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 643–653.
Published: 16 April 2012
...Ting Jin; Daqian Xu; Qiurong Ding; Yixuan Zhang; Chenqian Mao; Yi Pan; Zhenzhen Wang; Yan Chen PAQR10 (progestin and adipoQ receptor 10) is a Golgi-localized protein that is able to enhance the retention and activation of Ras proteins in the Golgi apparatus, subsequently leading to a sustained ERK...
Includes: Supplementary data
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Biochem J (2012) 441 (1): 407–416.
Published: 14 December 2011
..., whereas PLD1 overexpression markedly induced Bcl-2 expression. bFGF treatment activated Ras, Src, PI3K (phosphoinositide 3-kinase), PLCγ (phospholipase Cγ) and PKCα (protein kinase Cα). Among these molecules, Src and PKCα were not required for Bcl-2 expression. PLD activity was decreased by Ras, PI3K...
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Biochem J (2011) 433 (1): 1–9.
Published: 15 December 2010
... homoeostasis Golgi complex mitotic entry Ras signalling Src The GC (Golgi complex) is a central organelle in the endomembrane system whose origin dates back to the last common eukaryotic ancestor [ 1 ]. Despite its ancient origin and the conservation of many of the Golgi-associated proteins...
Includes: Supplementary data
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Biochem J (2010) 427 (2): 217–224.
Published: 29 March 2010
... Pseudomonas aeruginosa Ras 1 These authors contributed equally to this work. 2 Present address: Department of Medical Biosciences/Pathology, Umeå University, SE-901 87, Umeå, Sweden. 3 Present address: Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA...
Includes: Supplementary data
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Biochem J (2006) 399 (3): 493–501.
Published: 13 October 2006
... the phosphorylation of ERK1/2 by sustained intracellular acidosis, as did inhibition of Raf-1 with GW 5074 or ZM 336372. Interference with Ras signalling by the adenoviral expression of dominant-negative N17-Ras protein or with FPT III (farnesyl protein transferase inhibitor III) also prevented acidosis-induced ERK1...
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Biochem J (2006) 394 (3): 557–562.
Published: 24 February 2006
... showed that Gα q competes with Ras, a PI3K activator, for binding to p110α/p85α. Interestingly, co-precipitation studies using deletion mutants showed that Gα q binds to the p85-binding domain of p110α and not to the Ras-binding domain. Expression of constitutively active Gα q Q209L in cells inhibited...
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Biochem J (2006) 393 (1): 235–243.
Published: 12 December 2005
...Harjeet Kaur; Chang Shin Park; Jodee M. Lewis; Jason M. Haugh In growth-factor-stimulated signal transduction, cell-surface receptors recruit PI3Ks (phosphoinositide 3-kinases) and Ras-specific GEFs (guanine nucleotide-exchange factors) to the plasma membrane, where they produce 3′-phosphorylated...
Includes: Supplementary data
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Biochem J (2005) 389 (1): 1–11.
Published: 21 June 2005
... will consider specifically how Ras proteins interact with the plasma membrane. The focus will be on recent studies that provide novel spatial and dynamic insights into the micro-environments that different Ras proteins utilize for signal transduction. We will correlate these recent studies suggesting Ras...
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Biochem J (2005) 388 (2): 445–454.
Published: 24 May 2005
... the Sprouty domain is required for Spred-2 function. We also demonstrate that the inhibitory function of Spred proteins is restricted to the Ras/MAPK pathway, that tyrosine phosphorylation is not required for this function, and that the Sprouty domain mediates heterodimer formation of Spred proteins. Growth...
Includes: Supplementary data
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Biochem J (2005) 386 (1): 177–189.
Published: 08 February 2005
...Sarah J. O'MEARA; B. Therese KINSELLA Like Ras, farnesylation of the IP (prostacyclin receptor) is required for its efficient intracellular signalling, and hence the IP represents a potential target for inhibition by FTIs [FTase (farnesyl protein transferase) inhibitors]. Herein, the effect...
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Biochem J (2004) 380 (3): 767–774.
Published: 15 June 2004
...Simon A. WOODCOCK; David A. HUGHES Btl (breathless) and Htl (heartless), the two FGFRs (fibroblast growth factor receptors) in Drosophila melanogaster , control cell migration and differentiation in the developing embryo. These receptors signal through the conserved Ras/mitogen-activated protein...
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Biochem J (2004) 377 (1): 257–264.
Published: 01 January 2004
...Lisa M. SHANTZ ODC (ornithine decarboxylase) activity is induced following ras activation. However, the Ras effector pathways responsible are unknown. These experiments used NIH-3T3 cells expressing partial-loss-of-function Ras mutants to activate selectively pathways downstream of Ras and examined...
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Biochem J (2003) 370 (3): 1047–1054.
Published: 15 March 2003
...Juan CADIÑANOS; Walter K. SCHMIDT; Antonio FUEYO; Ignacio VARELA; Carlos LÓPEZ-OTÍN; José M.P. FREIJE Post-translational processing of proteins such as the Ras GTPases, which contain a C-terminal CaaX motif (where C stands for cysteine, a for aliphatic and X is one of several amino acids), includes...
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Biochem J (2002) 366 (2): 501–510.
Published: 01 September 2002
... proliferation, accompanied by a failure of the FGF-2-mediated induction of cyclins D1 and E. Overexpression of FPPS in fibroblasts also promotes increased farnesylation of Ras, and temporally extends FGF-2-stimulated activation of the Ras/ERK (extracellular-signal-regulated kinase) cascade. These data suggest...
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Biochem J (2000) 347 (1): 275–284.
Published: 27 March 2000
... promoter activation was significantly inhibited by SB203580 and dominant-negative MEKK1, but not by PD98059 or dominant-negative MEK1. Dominant-negative Ras inhibited both ERK activation and ANF up-regulation by Ang II, whereas constitutively active forms of Ras and MEK were sufficient to activate the ANF...
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Biochem J (2000) 346 (2): 501–508.
Published: 22 February 2000
...Zhimin LIANG; Timothy MATHER; Guangpu LI Structural and biochemical data indicate the importance of the phosphate-binding loop residues Gly 12 and Gly 13 of Ras both in the GTP hydrolysis reaction and in biological activity, but these two residues are not conserved in other Ras-related GTPases...
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Biochem J (1999) 338 (3): 643–649.
Published: 08 March 1999
...] and aortic endothelial cells [12]. The mechanism used by S1P to activate the p42}p44 MAPK cascade has not been characterized. Other G i -coupled receptors have been shown to regulate non-receptor tyrosine kinases, such as c-Src, which functions as an intermediate between G i bc and Ras-dependent p42}p44 MAPK...
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Biochem J (1999) 338 (2): 387–392.
Published: 22 February 1999
... activation of JNK by interleukin 1 (IL-1) in human fibroblasts and a pig aortic endothelial (PAE) cell line. This synergistic activation of JNK by IL-1 and PDGF was unaffected by bacterial toxins that inactivate Rho proteins and Ras. Since Rho proteins have been implicated in JNK activation, their possible...
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Biochem J (1999) 337 (2): 275–280.
Published: 08 January 1999
... Erk-1/-2 activation. Ectopic expression of inhibitory small GTPase Ras, RasN17, blocked the carbachol-induced Raf activation without affecting the activation of PKCε, while the inhibition of PKC blocked the Raf activation. Thus, these results suggest that carbachol-induced activation of PKCε mediates...
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