... preferred amino acid sequences resulting in proteolysis, but some also use exosites to select and cleave important proteins efficaciously. Such exosites have been found in a few caspases, notably caspase-7 that has a lysine patch (K 38 KKK) that binds RNA, which acts as a bridge to RNA-binding proteins...

...Kaiyue Qian; Mengyu Li; Junchao Wang; Min Zhang; Mingzhu Wang RNA-binding protein RBM38 was reported to bind the mRNA of several p53-related genes through its RRM domain and to up-regulate or down-regulate protein translation by increasing mRNA stability or recruitment of other effector proteins...

... species (chicken, lizard, and frog). We discover that the human homolog of RNase 1 has a pH optimum for catalysis, ability to degrade double-stranded RNA, and affinity for cell-surface glycans that are distinctly higher than those of its homologs. These attributes have relevance for human health. Moreover...

...Sianadh Dunn; Olivia Lombardi; Victoria H. Cowling The mRNA cap is a structure added to RNA pol II transcripts in eukaryotes, which recruits factors involved in RNA processing, nuclear export and translation initiation. RNA guanine-7 methyltransferase (RNMT)–RNA-activating miniprotein (RAM...

... relationship between a specific type of chemical modification in an SR protein and the regulation of alternative gene splicing programmes. kinase localization phosphorylation proline RNA splicing Proline-directed phosphorylation of serines regulates SR protein splicing activity...

...Robert N. Lightowlers; Zofia M. A. Chrzanowska-Lightowlers Genes encoding PPR (pentatricopeptide repeat)-containing proteins constitute one of the largest gene families in plants. The majority of these proteins are predicted to target organelles and to bind to RNA. Strikingly, there is a dearth...

...′-O-methyl RNA oligonucleotides containing locked nucleic acid monomers provide outstanding splice-switching activity. However, similar oligonucleotides with several mismatches do not impede splice-switching activity which indicates a risk for off-target effects. The splice-switching activity...

...-5A is essential for cell survival and proliferation. However, the precise function and interacting partners of eIF-5A remain unclear. We have shown previously that eIF-5A can bind to RRE (Rev-response element) and U6 RNA in vitro . Using SELEX (systematic evolution of ligands by exponential...

... in the rat heart. The majority of the products in the acid-insoluble, alkaline-treated fraction were identified as RNA degradation products (2´- and 3´-nucleoside monophosphates). A [ 14 C]adenosine labelling experiment showed that incorporation of adenosine into the acid-insoluble fraction was almost...