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Keywords: RNA
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Biochem J (2021) 478 (13): 2681–2696.
Published: 16 July 2021
... preferred amino acid sequences resulting in proteolysis, but some also use exosites to select and cleave important proteins efficaciously. Such exosites have been found in a few caspases, notably caspase-7 that has a lysine patch (K 38 KKK) that binds RNA, which acts as a bridge to RNA-binding proteins...
Biochem J (2020) 477 (1): 161–172.
Published: 10 January 2020
...Kaiyue Qian; Mengyu Li; Junchao Wang; Min Zhang; Mingzhu Wang RNA-binding protein RBM38 was reported to bind the mRNA of several p53-related genes through its RRM domain and to up-regulate or down-regulate protein translation by increasing mRNA stability or recruitment of other effector proteins...
Includes: Supplementary data
Biochem J (2017) 474 (13): 2219–2233.
Published: 21 June 2017
... species (chicken, lizard, and frog). We discover that the human homolog of RNase 1 has a pH optimum for catalysis, ability to degrade double-stranded RNA, and affinity for cell-surface glycans that are distinctly higher than those of its homologs. These attributes have relevance for human health. Moreover...
Includes: Supplementary data
Biochem J (2017) 474 (3): 377–384.
Published: 20 January 2017
...Sianadh Dunn; Olivia Lombardi; Victoria H. Cowling The mRNA cap is a structure added to RNA pol II transcripts in eukaryotes, which recruits factors involved in RNA processing, nuclear export and translation initiation. RNA guanine-7 methyltransferase (RNMT)–RNA-activating miniprotein (RAM...
Biochem J (2015) 466 (2): 311–322.
Published: 20 February 2015
... relationship between a specific type of chemical modification in an SR protein and the regulation of alternative gene splicing programmes. kinase localization phosphorylation proline RNA splicing Proline-directed phosphorylation of serines regulates SR protein splicing activity...
Includes: Supplementary data
Biochem J (2008) 416 (1): e5–e6.
Published: 28 October 2008
...Robert N. Lightowlers; Zofia M. A. Chrzanowska-Lightowlers Genes encoding PPR (pentatricopeptide repeat)-containing proteins constitute one of the largest gene families in plants. The majority of these proteins are predicted to target organelles and to bind to RNA. Strikingly, there is a dearth...
Biochem J (2008) 412 (2): 307–313.
Published: 14 May 2008
...′-O-methyl RNA oligonucleotides containing locked nucleic acid monomers provide outstanding splice-switching activity. However, similar oligonucleotides with several mismatches do not impede splice-switching activity which indicates a risk for off-target effects. The splice-switching activity...
Includes: Supplementary data
Biochem J (2004) 384 (3): 585–590.
Published: 07 December 2004
...-5A is essential for cell survival and proliferation. However, the precise function and interacting partners of eIF-5A remain unclear. We have shown previously that eIF-5A can bind to RRE (Rev-response element) and U6 RNA in vitro . Using SELEX (systematic evolution of ligands by exponential...
Biochem J (1999) 338 (2): 523–527.
Published: 22 February 1999
... in the rat heart. The majority of the products in the acid-insoluble, alkaline-treated fraction were identified as RNA degradation products (2´- and 3´-nucleoside monophosphates). A [ 14 C]adenosine labelling experiment showed that incorporation of adenosine into the acid-insoluble fraction was almost...