... reveal phase separation to be the principle mechanism behind the self-association of shell protein in the presence of salts and macromolecular crowding. The shell protein PduBB′ interacts with the enzyme diol-dehydratase PduCDE and co-assemble into phase separated liquid droplets. The co-assembly...

... to ensure their segregation to the P1 blastomere [ 24 ]. Lastly, MEG-3 is an RBP and co-precipitates with roughly 500 mRNAs in embryonic lysates, some of which are required for fertility [ 25 ]. In vitro and in vivo experiments demonstrated that RNA promotes phase separation of diverse proteins...

...Lior Pytowski; David J. Vaux; Létitia Jean Many protein misfolding diseases (e.g. type II diabetes and Alzheimer's disease) are characterised by amyloid deposition. Human islet amyloid polypeptide (hIAPP, involved in type II diabetes) spontaneously undergoes liquid–liquid phase separation (LLPS...

... a liquid–liquid phase separation process. These exciting ideas impacted the SR field by raising the hypothesis of SR foci as liquid condensates involved in transcriptional regulation. In this work, we review the current knowledge about SR foci formation under the light of the condensate model, analyzing...

...@mail.med.upenn.edu ) 9 1 2017 6 2 2017 9 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 disaggregase neurodegeneration phase separation prion-like domain RNA-binding proteins The problem of neurodegeneration remains...