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Keywords: Parkinson’s disease
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Biochem J (2024) 481 (4): 313–327.
Published: 19 February 2024
... are key players in the pathogenesis of Parkinson's disease (PD). The availability of multiple structures (full-length and truncated) has opened doors to explore intra-domain cross-talk in LRRK2. A helix extending from the WD40 domain and stably docking onto the kinase domain is common in all available...
Includes: Multimedia, Supplementary data
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Biochem J (2021) 478 (5): 997–1008.
Published: 04 March 2021
... with its direct involvement in the regulation of the activity of an important tumor suppressor p53 in the Mdm2/Mdmx-p53 pathway. Mutations in the RPS15 gene encoding rp uS19 are linked to diseases (Diamond Blackfan anemia, chronic lymphocytic leukemia and Parkinson's disease) caused either by defects...
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Biochem J (2019) 476 (3): 559–579.
Published: 08 February 2019
...Emmanouela Leandrou; Eliana Markidi; Anna Memou; Katerina Melachroinou; Elisa Greggio; Hardy J. Rideout The Parkinson's disease (PD) protein leucine-rich repeat kinase 2 (LRRK2) exists as a mixture of monomeric and dimeric species, with its kinase activity highly concentrated in the dimeric...
Includes: Supplementary data
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Biochem J (2018) 475 (7): 1271–1293.
Published: 09 April 2018
... to develop Parkinson's disease (PD). LRRK2 kinase activity is increased in several pathogenic mutations (N1437H, R1441C/G/H, Y1699C, G2019S), implicating hyperphosphorylation of a substrate in the pathogenesis of the disease. Identification of the downstream targets of LRRK2 is a crucial endeavor...
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Biochem J (2017) 474 (18): 3075–3086.
Published: 31 August 2017
...Nikhil Panicker; Valina L. Dawson; Ted M. Dawson Monogenetic, familial forms of Parkinson's disease (PD) only account for 5–10% of the total number of PD cases, but analysis of the genes involved therein is invaluable to understanding PD-associated neurodegenerative signaling. One such gene, parkin...
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Biochem J (2017) 474 (9): 1439–1451.
Published: 13 April 2017
...Helen Walden; Miratul M.K. Muqit Biochemical alterations found in the brains of Parkinson's disease (PD) patients indicate that cellular stress is a major driver of dopaminergic neuronal loss. Oxidative stress, mitochondrial dysfunction, and ER stress lead to impairment of the homeostatic...
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Biochem J (2017) 474 (7): 1273–1287.
Published: 23 March 2017
...Loes M. Stevers; Rens M.J.M. de Vries; Richard G. Doveston; Lech-Gustav Milroy; Luc Brunsveld; Christian Ottmann Binding of 14-3-3 proteins to leucine-rich repeat protein kinase 2 (LRRK2) is known to be impaired by many Parkinson's disease (PD)-relevant mutations. Abrogation of this interaction...
Includes: Supplementary data
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Biochem J (2016) 473 (18): 2757–2762.
Published: 12 September 2016
...Patrick A. Eyers Protein kinases catalyse the addition of phosphate groups to Ser/Thr and Tyr residues in cognate substrates and are mutated or hyperactive in a variety of diseases, making them important targets for rationally designed drugs. A good example is the Parkinson's disease-associated...
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Biochem J (2016) 473 (17): 2671–2685.
Published: 30 August 2016
... Parkinson's disease. Recent work has revealed that LRRK2 directly phosphorylates a conserved threonine/serine residue in the effector-binding switch-II motif of a number of Rab GTPase proteins, including Rab10. Here we describe a facile and robust method to assess phosphorylation of endogenous Rab10 in mouse...
Includes: Supplementary data
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Biochem J (2015) 470 (3): e21–e24.
Published: 04 September 2015
...Heather L. Melrose Pathogenic mutations and risk variants in LRRK2 (leucine-rich repeat kinase 2) represent the most common genetic cause of familial and sporadic PD (Parkinson's disease). LRRK2 protein is widely expressed throughout the brain and the periphery. Structurally, LRRK2 contains several...
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Biochem J (2015) 469 (1): 107–120.
Published: 19 June 2015
...Jing Zhao; Tyler P. Molitor; J. William Langston; R. Jeremy Nichols Activating mutations in the leucine rich repeat protein kinase 2 ( LRRK2 ) gene are the most common cause of inherited Parkinson's disease (PD). LRRK2 is phosphorylated on a cluster of phosphosites including Ser 910 , Ser 935 , Ser...
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Biochem J (2015) 467 (2): 303–310.
Published: 02 April 2015
... Parkinson's disease (PD). DJ1 loss of function disrupts mitochondrial function, but the signalling pathway, whereby it interferes with energy metabolism, is unknown. In the present study, we found that mouse embryonic fibroblasts (MEFs) obtained from DJ1-null ( dj1 −/− ) mice showed higher glycolytic rate...
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Biochem J (2015) 465 (1): 139–147.
Published: 12 December 2014
...Susanne Terheyden; Franz Y. Ho; Bernd K. Gilsbach; Alfred Wittinghofer; Arjan Kortholt Mutations in leucine-rich-repeat kinase 2 (LRRK2) are the most frequent cause of late-onset Parkinson's disease (PD). LRRK2 belongs to the Roco family of proteins which share a conserved Ras-like G-domain (Roc...
Includes: Supplementary data
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Biochem J (2014) 460 (3): e1–e3.
Published: 29 May 2014
...Gary S. Shaw The dysfunction of the E3 ubiquitin ligase Parkin is a key contributor to the development of early-onset Parkinson's disease. Parkin is responsible for the labelling of outer mitochondrial membrane proteins with the small modifier protein ubiquitin in response to oxidative stress...
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Biochem J (2014) 460 (1): 127–141.
Published: 25 April 2014
...Agne Kazlauskaite; Chandana Kondapalli; Robert Gourlay; David G. Campbell; Maria Stella Ritorto; Kay Hofmann; Dario R. Alessi; Axel Knebel; Matthias Trost; Miratul M. K. Muqit We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-induced putative kinase 1...
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Biochem J (2013) 456 (1): 119–128.
Published: 24 October 2013
... 935 , Ser 955 and Ser 973 , is important for PD (Parkinson's disease) pathogenesis as several PD-linked LRRK2 mutants are dephosphorylated at these sites. LRRK2 is also dephosphorylated in cells after pharmacological inhibition of its kinase activity, which is currently proposed as a strategy...
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Biochem J (2013) 450 (2): 265–274.
Published: 15 February 2013
... of these authors (email vprado@robarts.ca or mprado@robarts.ca ). 1 11 2012 15 11 2012 22 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 Alzheimer’s disease heart failure Parkinson’s disease sepsis synaptic vesicle vascular dementia...
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Biochem J (2013) 450 (1): 47–53.
Published: 24 January 2013
... , that belong to the P 5 -ATPase group have been identified in humans. Mutations of the human gene ATP13A2 underlie a form of PD (Parkinson's disease). Previous studies have suggested a relation between polyamines and P 5B -ATPases. We have recently shown that the cytotoxicity induced by the polyamine analogue...
Includes: Supplementary data
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Biochem J (2012) 443 (3): 719–726.
Published: 16 April 2012
...María Soledad Celej; Rabia Sarroukh; Erik Goormaghtigh; Gerardo D. Fidelio; Jean-Marie Ruysschaert; Vincent Raussens Parkinson's disease is an age-related movement disorder characterized by the presence in the mid-brain of amyloid deposits of the 140-amino-acid protein AS (α-synuclein...
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Biochem J (2012) 441 (3): 987–998.
Published: 16 January 2012
...Genta Ito; Takeshi Iwatsubo Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene have been identified in PARK8, a major form of autosomal-dominantly inherited familial Parkinson's disease, although the biochemical properties of LRRK2 are not fully understood. It has been proposed that LRRK2...
Includes: Supplementary data
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Biochem J (2011) 438 (3): 415–426.
Published: 26 August 2011
...@lnu.se 28 2 2011 28 4 2011 4 5 2011 26 8 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease computer simulation integrative biology molecular dynamics Parkinson's disease Amyloid-related diseases comprise a group...
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Biochem J (2010) 430 (3): e5–e6.
Published: 27 August 2010
...Iakov N. Rudenko; Mark R. Cookson Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common cause of familial PD (Parkinson’s disease). Mutations that cause PD are found in either the GTPase or kinase domains of LRRK2 or an intervening sequence called the COR [C-terminus of ROC (Ras...
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Biochem J (2009) 418 (2): 311–323.
Published: 11 February 2009
...Jung-Ho Lee; In-Hwan Lee; Young-Jun Choe; Sungsoo Kang; Hui Young Kim; Wei-Ping Gai; Ji-Sook Hahn; Seung R. Paik α-Synuclein is a pathological component of PD (Parkinson's disease) by participating in Lewy body formation. JC-1 (5,5′,6,6′-tetrachloro-1,1,3,3′-tetraethylbenzimidazolyl carbocyanine...
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Biochem J (2008) 413 (1): 1–13.
Published: 12 June 2008
...Philip A. Robinson Parkinson's disease (PD), the second most common age-related neurodegenerative disease, results in abnormalities in motor functioning. Many fundamental questions regarding its aetiology remain unanswered. Pathologically, it is not until 70–80% of the dopaminergic neurons from...
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Biochem J (2006) 393 (1): 343–349.
Published: 12 December 2005
... The Biochemical Society, London 2006 lipid–protein adduct neurodegenerative disorder Parkinson's disease peroxynitrite α-synuclein nitration Egg PC (phosphatidylcholine), 1,2-dipalmitoyl-PA (phosphatidic acid) (PA sat ) and 1,2-dilinoleoyl-PA (PA uns ) were obtained from Avanti Polar Lipids...
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Biochem J (2004) 378 (3): 975–982.
Published: 15 March 2004
... 11 2003 The Biochemical Society, London ©2004 2004 calcium channel nerve growth factor non-transferrin-bound iron Parkinson's disease PC12 cell transient receptor potential canonical 6 (TRPC6) Abbreviations used: DAG, diacylglycerol; DMEM, Dulbecco's modified Eagle's medium...
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Biochem J (2003) 373 (1): 25–32.
Published: 01 July 2003
...Venugopalan D. NAIR; C. Warren OLANOW; Stuart C. SEALFON Whereas dopamine agonists are known to provide symptomatic benefits for Parkinson's disease, recent clinical trials suggest that they might also be neuroprotective. Laboratory studies demonstrate that dopamine agonists can provide...
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Biochem J (2001) 357 (3): 881–886.
Published: 25 July 2001
...@mcmaster.ca ). 24 11 2000 17 4 2001 30 5 2001 The Biochemical Society, London ©2001 2001 ascorbate dopaminergic neurons nitric oxide synthase Parkinson's disease transferrin Abbreviations used: NGF, nerve growth factor; nNOS, neuronal nitric oxide synthase; NTA...