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Keywords: Parkin
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Articles
Biochem J (2020) 477 (23): 4581–4597.
Published: 08 December 2020
... and neurodegenerative disorders, remains unknown. In this study, AβO induced mitochondrial dysfunction, enhanced Parkin-mediated mitophagy, and reduced mitochondrial quantities in hippocampal neuronal cells (HT-22 cells). We demonstrated that AβO-induced mitochondrial fragmentation could be rescued to the elongated...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (6): 1109–1122.
Published: 23 March 2020
... be prevented by cyclosporine A (a blocker of mitochondrial permeability transition pore). These results indicate that iron cytotoxicity is mediated by α-synuclein acting on mitochondria. Likewise siRNA mediated knock-down of Parkin causes an accumulation of α-synuclein accompanied by mitochondrial dysfunction...
Includes: Supplementary data
Articles
Biochem J (2014) 460 (3): e1–e3.
Published: 29 May 2014
...Gary S. Shaw The dysfunction of the E3 ubiquitin ligase Parkin is a key contributor to the development of early-onset Parkinson's disease. Parkin is responsible for the labelling of outer mitochondrial membrane proteins with the small modifier protein ubiquitin in response to oxidative stress...
Articles
Biochem J (2014) 460 (1): 127–141.
Published: 25 April 2014
...) is activated by mitochondrial depolarization and stimulates the Parkin E3 ligase by phosphorylating Ser 65 within its Ubl (ubiquitin-like) domain. Using phosphoproteomic analysis, we identified a novel ubiquitin phosphopeptide phosphorylated at Ser 65 that was enriched 14-fold in HEK (human embryonic kidney...
Includes: Supplementary data