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Keywords: PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced putative kinase 1 (PINK1)
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Articles

Switching on ubiquitylation by phosphorylating a ubiquitous activator

Gary S. Shaw
Journal: Biochemical Journal
Biochem J (2014) 460 (3): e1–e3.
DOI: https://doi.org/10.1042/BJ20140459
Published: 29 May 2014
.... A. Alpi A. F. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin–RING ligase complexes EMBO J. 2013 32 2848 2860 10.1038/emboj.2013.209 24076655 mitophagy Parkin Parkinson’s disease PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced...
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Articles

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser 65

Agne Kazlauskaite, Chandana Kondapalli, Robert Gourlay, David G. Campbell, Maria Stella Ritorto, Kay Hofmann, Dario R. Alessi, Axel Knebel, Matthias Trost, Miratul M. K. Muqit
Journal: Biochemical Journal
Biochem J (2014) 460 (1): 127–141.
DOI: https://doi.org/10.1042/BJ20140334
Published: 25 April 2014
... phosphorylates ubiquitin at Ser 65 and that phosphorylated ubiquitin acts as a direct activator of Parkin. Parkin Parkinson’s disease phosphorylation PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced putative kinase 1 (PINK1) ubiquitin Mutations in PINK1 [PTEN...
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Includes: Supplementary data