...Jack A. Prescott; Kathryn Balmanno; Jennifer P. Mitchell; Hanneke Okkenhaug; Simon J. Cook Inhibitor of kappa B (IκB) kinase β (IKKβ) has long been viewed as the dominant IKK in the canonical nuclear factor-κB (NF-κB) signalling pathway, with IKKα being more important in non-canonical NF-κB...

... (PA)-treated hepatocytes, whereas C7ORF41 knockdown showed the opposite effects. Mechanistically, we found the anti-inflammatory role of C7ORF41 was attributed to the suppression of NF-κB p65-mediated induction of inflammatory cytokines. Moreover, we demonstrated that the suppression of C7ORF41...

... pathway, including the mitogen-activated protein kinases (MAPKs) and the NF (nuclear factor)-κB signaling pathway, but its analog L-K5, which had the same amino acid sequence as L-K6 but no Lys residue at the –COOH terminal, only inhibited the phosphorylation of I-κB and NF-κB. Importantly, L-K6 and L-K5...

... (CARD14) is a member of the CARMA protein family that includes the structurally related CARD11 adaptor that mediates NF-κB activation by antigen receptors. We investigated the mechanism by which CARD14 mutation in psoriasis activates NF-κB. In contrast with wild-type CARD14, CARD14 E138A and CARD14 G117S...

... known to reside in the mitochondria or regulate NF-κB (nuclear factor κB) signalling. Analysis of early time-points revealed that IAP antagonist treatment stimulated rapid ubiquitination of NF-κB signalling proteins, including TRAF2 [TNF (tumour necrosis factor) receptor-associated factor 2], HOIL-1...

... shown to be regulated by nitric oxide produced by the induction of neuronal nitric oxide synthase after removal of RA. Nitric oxide functions by inhibiting NF-κB (nuclear factor κB) nuclear translocation and the subsequent binding to the putative NF-κB response element (at −19 to −23) within the 1B...

...), a protein known to modulate NF-κB (nuclear factor-κB) nuclear translocation, was significantly up-regulated. On the other hand, there was a time-dependent degradation of IκBα protein levels in response to weaning, suggesting a role for NF-κB. Furthermore, we have demonstrated, using chromatin...

... cardiotoxicity, the mechanism of DOX-induced apoptosis remains unclear. In the present study, we investigated the role of reactive oxygen species and the nuclear transcription factor nuclear factor κB (NF-κB) during apoptosis induced by DOX in bovine aortic endothelial cells (BAECs) and adult rat cardiomyocytes...

... and phosphoinositide 3-kinase (PI-3K) was then analysed. Nuclear factor κB (NF-κB) activation was also detected in THP-1 cells transiently transfected with an NF-κB-driven luciferase reporter gene. We found that binding of both types of integrin to their natural ligands activated ERK in a Syk- and PI-3K-dependent...

... of tumour necrosis factor (TNF) induced by lipopolysaccharide (LPS) in peritoneal macrophages is up-regulated by MT via the modulation of nuclear factor κB (NF-κB) activity. This conclusion is supported by the following observations: (1) LPS stimulated the secretion of less TNF activity from MT...

... endocytosis endothelium mevastatin NF-κB shedding Abbreviations used: DMEM, Dulbecco's modified Eagle's medium; EMSA, electrophoretic mobility shift assay; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HMG-CoA, hydroxymethylglutaryl-CoA; HRP, horseradish peroxidase; IL-1β, interleukin-1β; NF...

...Pisate J. KAMTHONG; Ming-chi WU We have recently reported that interleukin-1α (IL-1α) can induce human macrophage colony-stimulating factor (M-CSF) expression through nuclear factor κB (NF-κB) activation, and treatment of human pancreatic MIA PaCa-2 cancer cells with forskolin or cAMP attenuated...

... of Lancaster, Lancaster LA1 4YW, U.K. 2 To whom correspondence should be addressed (e-mail j.rivett@bristol.ac.uk). 4 6 1999 10 11 1999 4 1 2000 The Biochemical Society, London © 2000 2000 chymotrypsin-like activity tight binding inhibitors NF-κB Biochem. J. (2000) 346...