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Keywords: NADPH oxidase
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Biochem J (2014) 462 (2): 337–345.
Published: 07 August 2014
...Aymen Ezzine; Hager Souabni; Tania Bizouarn; Laura Baciou The flavocytochrome b 558 of the phagocyte NADPH oxidase complex comprises two membrane proteins, a glycosylated gp91 phox and a non-glycosylated p22 phox . Gp91 phox contains all of the redox carriers necessary to reduce molecular oxygen...
Biochem J (2009) 422 (2): 373–382.
Published: 13 August 2009
... oxidase in phagocytes. Rac1 also contributes to activation of the non-phagocytic oxidases Nox1 (NADPH oxidase 1) and Nox3 (NADPH oxidase 3), each related closely to gp91 phox /Nox2. It has remained controversial whether the insert region of Rac (amino acids 123–135), unique to the Rho subfamily proteins...
Biochem J (2008) 411 (3): 531–541.
Published: 14 April 2008
...-dependent mechanism of c-Src activation following H/R injury and found that ROS (reactive oxygen species) generated by endosomal Noxs (NADPH oxidases) are critical for this process. Endocytosis following H/R was required for the activation of endosomal Noxs, c-Src activation, and the ability of c-Src...
Biochem J (2006) 400 (3): 431–438.
Published: 28 November 2006
...Gábor L. Petheő; Nathalie C. Girardin; Nicolas Goossens; Gergely Z. Molnár; Nicolas Demaurex The phagocytic NADPH oxidase (phox) moves electrons across cell membranes to kill microbes. The activity of this lethal enzyme is tightly regulated, but the mechanisms that control phox inactivation...
Biochem J (2006) 398 (2): 303–310.
Published: 15 August 2006
...Noriaki Arakawa; Masato Katsuyama; Kuniharu Matsuno; Norifumi Urao; Yoshiaki Tabuchi; Mitsuhiko Okigaki; Hiroaki Matsubara; Chihiro Yabe-Nishimura NADPH oxidase is implicated in the pathogenesis of various cardiovascular disorders. In vascular smooth muscle cells (VSMC), expression of NOX1 (NADPH...
Includes: Supplementary data
Biochem J (2006) 398 (1): 73–82.
Published: 27 July 2006
... [Wang and O (2001) Biochem. J. 357 , 233–240] demonstrated that Hcy (homocysteine) treatment caused a significant elevation of intracellular superoxide anion, leading to increased expression of chemokine receptor in monocytes. NADPH oxidase is primarily responsible for superoxide anion production...
Biochem J (2006) 396 (1): 183–192.
Published: 26 April 2006
...Ikuo Nobuhisa; Ryu Takeya; Kenji Ogura; Noriko Ueno; Daisuke Kohda; Fuyuhiko Inagaki; Hideki Sumimoto Activation of the superoxide-producing phagocyte NADPH oxidase, crucial for host defence, requires an SH3 (Src homology 3)-domain-mediated interaction of the regulatory protein p47 phox with p22...
Biochem J (2005) 390 (3): 761–767.
Published: 05 September 2005
...Chun Yuan Fan; Masato Katsuyama; Chihiro Yabe-Nishimura NADPH oxidase is the major source of superoxide production in cardiovascular tissues. We reported previously that PG (prostaglandin) F2α caused hypertrophy of vascular smooth muscle cells by induction of NOX1, a catalytic subunit of NADPH...
Biochem J (2005) 390 (2): 591–602.
Published: 23 August 2005
...Eleonora Olivetta; Donatella Pietraforte; Ilaria Schiavoni; Maurizio Minetti; Maurizio Federico; Massimo Sanchez The NADPH oxidase enzymatic complex participates in the oxidative burst by producing ROS (reactive oxygen species). Altered levels of ROS production may have pathogenetic implications...
Biochem J (2005) 389 (2): 315–323.
Published: 05 July 2005
.... Death of ATDC5 cells after IL-1β treatment was prevented by an NADPH-oxidase inhibitor, AEBSF [4-(2-aminoethyl)benzenesulphonyl fluoride], an NO synthase inhibitor, L -NAME ( N G -nitro- L -arginine methyl ester), and a ONOO − scavenger, uric acid. The viability of ATDC5 cells was reduced by the ONOO...
Biochem J (2005) 388 (2): 485–491.
Published: 24 May 2005
...Gábor L. PETHEŐ; Nicolas DEMAUREX The phagocytic NADPH oxidase generates superoxide by transferring electrons from cytosolic NADPH to extracellular O 2 . The activity of the oxidase at the plasma membrane can be measured as electron current ( I e ), and the voltage dependence of I e was recently...
Includes: Supplementary data
Biochem J (2005) 386 (3): 549–556.
Published: 08 March 2005
..., such as proliferation, apoptosis and tumour formation. In the present study, we focus on its inhibition of the neutrophil respiratory burst, an important element of non-specific immunological defence. The superoxide anion-producing enzyme, NADPH oxidase, is quiescent in resting cells. Upon cell stimulation, the redox...
Biochem J (2005) 386 (3): 401–416.
Published: 08 March 2005
...Yvonne GROEMPING; Katrin RITTINGER The NADPH oxidase of professional phagocytes is a crucial component of the innate immune response due to its fundamental role in the production of reactive oxygen species that act as powerful microbicidal agents. The activity of this multi-protein enzyme...
Biochem J (2005) 386 (2): 255–261.
Published: 22 February 2005
...Masato KATSUYAMA; ChunYuan FAN; Noriaki ARAKAWA; Toru NISHINAKA; Makoto MIYAGISHI; Kazunari TAIRA; Chihiro YABE-NISHIMURA NADPH oxidase is the major source of superoxide production in cardiovascular tissues. We and others reported that PG (prostaglandin) F 2α , PDGF (platelet-derived growth factor...
Includes: Supplementary data
Biochem J (2005) 385 (3): 649–657.
Published: 24 January 2005
... further support for our proposed role for gp91 phox as the NADPH oxidase-associated proton channel. 1 To whom correspondence should be addressed (email L.M.Henderson@bris.ac.uk ) 18 5 2004 7 9 2004 17 9 2004 17 9 2004 The Biochemical Society, London 2005 confocal...
Biochem J (2004) 382 (3): 981–986.
Published: 07 September 2004
...Marie-Hélène PACLET; Lydia M. HENDERSON; Yannick CAMPION; Françoise MOREL; Marie-Claire DAGHER Nox2/gp91 phox (where phox is ph agocyte ox idase) is the catalytic membrane subunit of the granulocyte NADPH oxidase complex involved in host defence. The current model of membrane topology of Nox2...
Biochem J (2004) 378 (2): 539–547.
Published: 01 March 2004
... NADPH oxidase, and this oxidase activity is required for VCAM-1-dependent lymphocyte migration. We reported previously that a mouse microvascular endothelial cell line promotes lymphocyte migration that is dependent on VCAM-1, but not on other known adhesion molecules. Here we have investigated...
Biochem J (2003) 374 (2): 315–319.
Published: 01 September 2003
...Tosti J. MANKELOW; Etai PESSACH; Rachel LEVY; Lydia M. HENDERSON The absolute requirement for the 85 kDa cytosolic phospholipase A 2 (cPLA 2 ) in the PMA stimulation of proton efflux through the NADPH-oxidase-associated proton channel, has previously been demonstrated using a PLB-985 cell line...
Biochem J (2003) 373 (1): 221–229.
Published: 01 July 2003
...Guihong PENG; Jin HUANG; Mellonie BOYD; Michael E. KLEINBERG In an early step in the assembly of the phagocyte NADPH oxidase, p47-phox translocates from the cytosol to the membrane, mediated by engagement of the N-termini of two p47-phox Src homology 3 (SH3) domains with a proline-rich region (PRR...
Biochem J (1999) 344 (3): 859–866.
Published: 08 December 1999
...Emer P. REEVES; Lodewijk V. DEKKER; Louisa V. FORBES; Frans B. WIENTJES; Ann GROGAN; Darryl J. C. PAPPIN; Anthony W. SEGAL p47 phox is an essential component of the NADPH oxidase, and phosphorylation of p47 phox is associated with activation of the enzyme. Here we have used p47 phox affinity...
Biochem J (1999) 338 (2): 359–366.
Published: 22 February 1999
... in the activation of a membrane-associated kinase that may play a part in the regulation of neutrophil NADPH oxidase through its ability to phosphorylate p47 phox . Biochem. J. (1999) 338, 359 366 (Printed in Great Britain) 359 Characterization and partial purification of a novel neutrophil membrane- associated...