... (Warburg effect) in the tumor microenvironment supports the transport function of PEPT1 in the maintenance of amino acid nutrition in cancer cells by inducing MMPs and DPPIV to generate peptide substrates for PEPT1 and by generating a H + gradient across the plasma membrane to energize PEPT1. Taken...

...Lise Boon; Estefania Ugarte-Berzal; Jennifer Vandooren; Ghislain Opdenakker Matrix metalloproteases (MMPs) are crucial components of a complex and dynamic network of proteases. With a wide range of potential substrates, their production and activity are tightly controlled by a combination...