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Keywords: Leishmania
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Biochem J (2019) 476 (2): 179–191.
Published: 18 January 2019
... buffer (20 mM TEA, 5 mM MgCl 2 , 50 mM KCl, 10% glycerol, pH 7.4) and tetrameric fractions eluted with 1.5 column volumes (CVs) of gel filtration buffer. Leishmania infantum PFK (LmPFK) IMAC eluates were loaded onto a HiPrep 26/10 Desalting column (GE Healthcare) pre-equilibrated with gel filtration...
Includes: Supplementary data
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Biochem J (2018) 475 (5): 887–899.
Published: 06 March 2018
...Rubén Perandrés-López; María P. Sánchez-Cañete; Francisco Gamarro; Santiago Castanys The P4 family of P-type ATPases (P4-ATPases) plays an important role in maintaining phospholipid asymmetry in eukaryotic cell membranes. Leishmania miltefosine transporter (LMT) is a plasma membrane (PM) P4-ATPase...
Includes: Supplementary data
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Biochem J (2018) 475 (1): 87–97.
Published: 02 January 2018
...Ana Perea; José Ignacio Manzano; Yasuhisa Kimura; Kazumitsu Ueda; Santiago Castanys; Francisco Gamarro The Leishmania LABCG2 transporter has a key role in the redox metabolism of these protozoan parasites. Recently, the involvement of LABCG2 in virulence, autophagy and oxidative stress has been...
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Biochem J (2015) 465 (2): 247–257.
Published: 06 January 2015
...Hamed Hojjat; Armando Jardim Trafficking of peroxisomal targeting signal 1 (PTS1) proteins to the Leishmania glycosome is dependent on the docking of the LdPEX5 receptor to LdPEX14 on the glycosomal membrane. A combination of deletion and random mutagenesis was used to identify residues...
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Biochem J (2011) 438 (2): 229–244.
Published: 12 August 2011
... (causing Chagas' disease) and Leishmania spp. (causing leishmaniasis), as well as the apicomplexan Plasmodium spp. causing malaria. These diseases afflict people globally, killing millions and disabling many more, and impose further threats due to the rapid appearance and spread of parasite strains...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 424 (3): 367–374.
Published: 10 December 2009
..., in contrast with its mammalian counterpart which is predominately nucleoplasmic, is localized at the nuclear rim. The aim of the present study was to characterize the Ld Ran ( Leishmania donovani Ran) orthologue with an emphasis on the Ran–histone association. Ld Ran was found to be developmentally regulated...
Includes: Supplementary data
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Biochem J (2009) 420 (3): 451–462.
Published: 27 May 2009
...Roderick A. M. Williams; Gareth D. Westrop; Graham H. Coombs Genome mining and biochemical analyses have shown that Leishmania major possesses two pathways for cysteine synthesis – the de novo biosynthesis pathway comprising SAT (serine acetyltransferase) and CS (cysteine synthase) and the RTS...
Includes: Supplementary data
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Biochem J (2008) 414 (3): 375–381.
Published: 27 August 2008
... drug discovery glutathione peroxidase Leishmania Trypanosoma trypanothione Human African trypanosomiasis (sleeping sickness) is responsible for an estimated 80000 new cases and 30000 deaths each year [ 1 ]. Current therapeutics against the protozoan parasite ( Trypanosoma brucei sspp...
Includes: Supplementary data
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Biochem J (2004) 381 (2): 405–412.
Published: 06 July 2004
...Helen DENTON; Joanne C. McGREGOR; Graham H. COOMBS The reason why Leishmania parasites are susceptible to organic antimonial drugs, the standard chemotherapeutic agents for over 50 years, apparently lies in the fact that the mammalian stage of the parasite reduces the pentavalent form...
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Biochem J (2003) 375 (1): 221–230.
Published: 01 October 2003
...J. Román LUQUE-ORTEGA; José M. SAUGAR; Cristina CHIVA; David ANDREU; Luis RIVAS Leishmanicidal drugs interacting stoichiometrically with parasite plasma membrane lipids, thus promoting permeability, have raised significant expectations for Leishmania chemotherapy due to their nil or very low...
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Biochem J (2003) 369 (3): 447–452.
Published: 01 February 2003
...Sanjay GHOSH; Srikanta GOSWAMI; Samit ADHYA Intracellular parasitic protozoans of the genus Leishmania depend for their survival on the elaboration of enzymic and other mechanisms for evading toxic free-radical damage inflicted by their phagocytic macrophage host. One such mechanism may involve...
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