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Keywords: ERAD
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Biochem J (2019) 476 (18): 2545–2560.
Published: 20 September 2019
... control pathway called endoplasmic reticulum-associated degradation (ERAD). In ERAD, SM is ubiquitinated by MARCH6, an E3 ubiquitin ligase located in the endoplasmic reticulum (ER). However, several details of the ERAD process for SM remain elusive, such as the extraction mechanism from the ER membrane...
Includes: Supplementary data
Biochem J (2016) 473 (19): 3001–3012.
Published: 27 September 2016
...Akira Hosomi; Mika Fujita; Azusa Tomioka; Hiroyuki Kaji; Tadashi Suzuki Endoplasmic reticulum (ER)-associated degradation (ERAD) is a proteolytic pathway for handling misfolded or improperly assembled proteins that are synthesized in the ER. Cytoplasmic peptide: N -glycanase (PNGase...
Includes: Supplementary data
Biochem J (2016) 473 (18): 2863–2880.
Published: 12 September 2016
... reticulum-associated degradation (ERAD) substrates. Interaction of valosin-containing protein (p97/VCP) and RHBDL4 is crucial to retrotranslocate polyubiquitinated substrates for ERAD pathway. Here, we report the first complex structure of VCP-binding motif (VBM) with p97 N-terminal domain (p97N) at 1.88...
Includes: Multimedia, Supplementary data
Biochem J (2015) 466 (3): 571–585.
Published: 06 March 2015
... in increased levels of the connexins. Furthermore, treatment with trafficking inhibitors confirmed that both connexins undergo endoplasmic reticulum-associated degradation (ERAD), and that CIP75 preferentially interacts with the connexin proteins bound for proteasomal degradation from the ER. In addition, we...
Includes: Supplementary data