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Keywords: DNA topoisomeraseClose
Somdeb Bosedasgupta, Benu Brata Das, Souvik Sengupta, Agneyo Ganguly, Amit Roy, Gayatri Tripathi, Hemanta K. Majumder
Journal: Biochemical Journal
Biochem J (2008) 409 (2): 481–489.
Published: 21 December 2007
... liver topoisomerase I in having reduced affinity for DNA and reduced processivity [ 7 ]. Catalytic activity is derived chiefly from five conserved amino acids [ 8 ]: Arg 314 , Lys 352 , Arg 410 and His 453 from LdTOPIL (or L) and Tyr 222 from LdTOPIS (or S). DNA topoisomerases relieve...
Includes: Supplementary data