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Keywords: DNA topoisomerase
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Amino acids 39–456 of the large subunit and 210–262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania

Somdeb Bosedasgupta, Benu Brata Das, Souvik Sengupta, Agneyo Ganguly, Amit Roy, Gayatri Tripathi, Hemanta K. Majumder
Journal: Biochemical Journal
Biochem J (2008) 409 (2): 481–489.
https://doi.org/10.1042/BJ20071358
Published: 21 December 2007
... liver topoisomerase I in having reduced affinity for DNA and reduced processivity [ 7 ]. Catalytic activity is derived chiefly from five conserved amino acids [ 8 ]: Arg 314 , Lys 352 , Arg 410 and His 453 from LdTOPIL (or L) and Tyr 222 from LdTOPIS (or S). DNA topoisomerases relieve...
View article titled, Amino acids 39–456 of the large subunit and 210–262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania
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Includes: Supplementary data