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Keywords: DNA repair
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Biochem J (2020) 477 (16): 2935–2947.
Published: 19 August 2020
...Ryan J. Buckley; Kevin Kramm; Christopher D. O. Cooper; Dina Grohmann; Edward L. Bolt The DNA helicase L arge h elicase -r elated (Lhr) is present throughout archaea, including in the Asgard and Nanoarchaea, and has homologues in bacteria and eukaryotes. It is thought to function in DNA repair...
Includes: Supplementary data
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Biochem J (2017) 474 (11): 1837–1852.
Published: 16 May 2017
... Poznański ( jarek@ibb.waw.pl ) 15 11 2016 7 4 2017 13 4 2017 13 4 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 acrolein AlkB dioxygenase DNA repair mutagenesis substrate binding Acrolein (ACR), a highly...
Includes: Supplementary data
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Biochem J (2016) 473 (9): 1237–1245.
Published: 26 April 2016
...Ning Tsao; Ya-Chi Yang; Yu-Jyun Deng; Zee-Fen Chang Cellular supply of dNTPs via RNR (ribonucleotide reductase) is crucial for DNA replication and repair. It has been shown that DNA-damage-site-specific recruitment of RNR is critical for DNA repair efficiency in quiescent cells. The catalytic...
Includes: Supplementary data
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Biochem J (2015) 468 (2): 227–244.
Published: 22 May 2015
...) (SIGMAFAST™; Sigma–Aldrich) and absorbance readings were taken at 490 nm. The absorbance was corrected for the background signal in the presence of BSA. DNA repair flap endonuclease helicase RecQ replication telomere The RecQ helicase family is a group of highly conserved DNA-unwinding...
Includes: Supplementary data
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Biochem J (2013) 456 (1): 89–98.
Published: 24 October 2013
... SIRT1 and TDG may mediate DNA repair, gene expression and FU (5-fluorouracil)-mediated cytotoxicity. 1 Present address: Department of Natural & Physical Sciences, Life Sciences Institute, Baltimore City Community College, MD 21201, U.S.A. 2 To whom correspondence should be addressed...
Includes: Supplementary data
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Biochem J (2013) 453 (1): 125–136.
Published: 13 June 2013
... of NKX3.1 on cell survival after DNA damage as topoisomerase knockdown blocked the effect of NKX3.1 on clonogenicity after DNA damage. Therefore NKX3.1 and topoisomerase I interact in vitro and in cells to affect the CPT sensitivity and DNA-repair functions of NKX3.1. GST (glutathione transferase)–Topo70...
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Biochem J (2012) 445 (3): 393–401.
Published: 13 July 2012
... Biochemical Society 2012 Arabidopsis DNA double-strand break DNA repair epigenetics recombination Repair of DNA DSBs (double-strand breaks), one of the most cytotoxic forms of DNA damage, takes place in the context of chromatin. Histones form the protein component of chromatin, and play...
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Biochem J (2012) 443 (1): 13–26.
Published: 14 March 2012
... separation during mitosis. 1 To whom correspondence should be addressed (email e.petermann@bham.ac.uk ). 30 11 2011 10 1 2012 11 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell cycle checkpoint DNA repair DNA helicase homologous...
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Biochem J (2012) 442 (1): 77–84.
Published: 27 January 2012
.../licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. damage inducible gene G (DinG) DNA repair helicase iron–sulfur nuclease xeroderma pigmentosum complementation group D (XPD...
Includes: Supplementary data
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Biochem J (2011) 440 (2): 293–300.
Published: 14 November 2011
... Biochemical Society 2011 DNA repair flap endonuclease 1 genome stability hSuv3 helicase RecQ helicase family replication protein A The Suv3 helicases (SUV3, hSUV3p and SUPV3L1) were originally identified in a study on mitochondrial RNA metabolism in Saccharomyces cerevisiae [ 1...
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Biochem J (2011) 436 (3): 559–566.
Published: 27 May 2011
...@u.washington.edu ). 9 11 2010 15 3 2011 4 4 2011 4 4 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 DNA repair DNA topoisomerase I proteasome tyrosyl-DNA phosphodiesterase (TDP) (1) To compare the effect of DNA length on substrate...
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Biochem J (2010) 430 (1): 119–128.
Published: 28 July 2010
... and indirect roles in processing G4 structures that arise in the single-stranded nucleic acid intermediates formed during DNA replication and gene expression. © The Authors Journal compilation © 2010 Biochemical Society 2010 DNA repair DNA replication genome stability G-quadruplex DNA (G4 DNA...
Includes: Supplementary data
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Biochem J (2010) 426 (3): 365–371.
Published: 24 February 2010
...Catherine Chailleux; Sandrine Tyteca; Christophe Papin; François Boudsocq; Nadine Puget; Céline Courilleau; Mikhaïl Grigoriev; Yvan Canitrot; Didier Trouche Chromatin modifications and chromatin-modifying enzymes are believed to play a major role in the process of DNA repair. The histone acetyl...
Includes: Supplementary data
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Biochem J (2009) 423 (2): 265–277.
Published: 25 September 2009
..., but have MutL proteins that harbour the D[M/Q]HAX 2 EX 4 E motif. The repair of misincorporated bases and damaged DNA is a critical process in maintaining genomic integrity. DNA-repair mechanisms have been well characterized in E. coli [ 3 , 4 ]. Very little is known about DNA-repair mechanisms...
Includes: Supplementary data
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Biochem J (2007) 401 (1): 1–11.
Published: 11 December 2006
... on p53, cell proliferation, invasiveness and metastasis. Chronic inflammation predisposes to malignancy, but the role of RS in this is likely to be complex because RS can sometimes act as anti-inflammatory agents. The Biochemical Society, London 2007 antioxidant cancer DNA repair nitric...
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Biochem J (2006) 398 (3): 319–337.
Published: 29 August 2006
..., London 2006 aging cancer DNA repair genomic instability helicase RecQ Understanding the molecular mechanisms of RecQ helicases is fundamental to deciphering the roles of these enzymes in cellular DNA metabolism. Since the discovery of Escherichia coli RecQ and its implicated role...
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Biochem J (2006) 393 (1): 303–309.
Published: 12 December 2005
...Lyne Jossé; Margaret E. Harley; Isabel M. S. Pires; David A. Hughes Human DSS1 associates with BRCA2, a tumour suppressor protein required for efficient recombinational DNA repair, but the biochemical function of DSS1 is not known. Orthologues of DSS1 are found in organisms such as budding yeast...
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Biochem J (2005) 387 (3): 859–863.
Published: 26 April 2005
... of interaction partners ( Figure 1 A). 1 To whom correspondence should be addressed (email sb419@hutchison-mrc.cam.ac.uk ). 30 9 2004 1 12 2004 10 12 2004 10 12 2004 The Biochemical Society, London 2005 DNA repair DNA replication proliferating cell nuclear antigen...
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Biochem J (2003) 374 (3): 577–606.
Published: 15 September 2003
... against replication fork demise, either through prevention of fork breakdown or restoration of productive DNA synthesis. Key words: cancer predisposition, chromosomal instability, DNA repair, progeroid syndrome, RecQ helicase, topoisomerase. INTRODUCTION Helicases are enzymes that use the energy derived...
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Biochem J (2000) 347 (2): 363–368.
Published: 10 April 2000
... with the known properties of the reaction in ŠiŠo and suggest that the new cell-free system will be suitable for purifying enzymes involved in homologous recombination. Key words: DNA repair, heteroduplex DNA, recombination. in hDNA formation. These biochemical studies argue that proteins encoded by genes...
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Biochem J (1999) 342 (2): 249–268.
Published: 24 August 1999
... supported by the identification of direct protein-protein interactions involving poly(ADP-ribose) polymerase (113 kDa PARP), an enzyme catalysing the formation of poly(ADP-ribose), and key effectors of DNA repair, replication and transcription reactions. The presence of PARP in these multiprotein complexes...
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Biochem J (1999) 337 (2): 311–317.
Published: 08 January 1999
... complex (pol a primase), which is necessary for the initiation of SV40 DNA replication [9,10,12,13]. During elongation, RPA stabilizes the ssDNA and stimulates pol a and pol d [14 16], even though the latter may not be essential for DNA replication [17]. RPA also functions in damaged DNA repair [18 20...