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Keywords: Bcl-xL
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Biochem J (2012) 444 (3): 475–485.
Published: 29 May 2012
... of a second VDAC1 molecule. When the N-terminal region α-helix structure was perturbed, intra-molecular cross-linking was abolished and dimerization was enhanced. This mutant also displays reduced voltage-gating and reduced binding to hexokinase, but not to the anti-apoptotic proteins Bcl-2 and Bcl-xL...
Biochem J (2012) 444 (1): 69–78.
Published: 26 April 2012
... embryonic fibroblasts), we found that the endogenous anti-apoptotic Bcl-2 protein Bcl-xL prevented apoptosis initiated by H 2 O 2 . The BH3 (Bcl-2 homology 3)-only Bcl-2 protein Noxa was required for H 2 O 2 -induced cell death and was the single BH3-only Bcl-2 protein whose pro-apoptotic activity...
Includes: Supplementary data
Biochem J (2011) 436 (2): 493–505.
Published: 13 May 2011
..., Bad, Bak or Bid. However, bound HK2 (hexokinase 2) and Bcl-xL were decreased in end-ischaemic mitochondria. We conclude that cytochrome c loss during ischaemia, caused by outer membrane permeabilization, is a major determinant of H 2 O 2 production by mitochondria under pathophysiological conditions...
Includes: Supplementary data
Biochem J (2003) 374 (2): 393–402.
Published: 01 September 2003
... in yeast. Using this sys- tem, we have focused on the action of the anti-apoptotic family member Bcl-xL, and have defined the quantitative relationships that underlie the antagonistic action of this protein on the lethal consequences of expression of the pro-apoptotic family member Bax. This system has...
Biochem J (2003) 371 (1): 115–124.
Published: 01 April 2003
... of action of NSAIDs is inhibition of cyclo-oxygenase 2 (COX-2) and thereby also inhibition of the production of the main COX-2 product prosta- glandin E # [8]. COX-2 was suggested as a possible link between Abbreviations used: Bad, Bcl-2/Bcl-XL-antagonist, causing cell death ; COX-2, cyclo-oxygenase 2; Int...
Biochem J (1999) 344 (2): 477–485.
Published: 24 November 1999
... are expressed as mean fluorescence units S.E.M. (n fl 3). *, Significantly less than basal activity (P ! 0.05). (a) 26 S proteasome activity (units) Treatment Control cells bcl-xL cells Chymotrypsin-like substrate (LLVY-NH-Mec) 85.9 4.3 58.3 3.8 Trypsin-like substrate (LSTR-NH-Mec) 11.6 0.1 11.8 0.9...
Biochem J (1999) 340 (2): 371–375.
Published: 25 May 1999
..., for FLAP than MK886. When tested to determine its ability to induce apoptosis, MK591 was less effective than MK886. At 8 h after treating FL5.12 cells with either 10 lM MK886 or 10 lM MK591, 27.0 Figure 1 FLAP (A) and bcl-xL (B) expression in various haematopoietic cell lines Cells were lysed...