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Keywords: BH3-mimetics
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Biochem J (2023) 480 (2): 161–176.
Published: 31 January 2023
... be developed to treat CML patients independently or in combination with TKIs. Here, we will discuss the mechanisms of BCR-ABL1-dependent and -independent resistance to TKIs and the use of BH3-mimetics as a potential tool to fight CML. The resistance to TKI treatment is defined as primary resistance...