1-28 of 28
Keywords: AMPK
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem J (2024) BCJ20240082.
Published: 09 April 2024
...Simon A. Hawley; Fiona M. Russell; D. Grahame Hardie The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. When activated by increases in ADP:ATP and/or AMP:ATP ratios (signalling energy deficit), AMPK acts to restore energy balance. Binding of AMP to one or more of three...
Articles
Biochem J (2024) 481 (5): 345–362.
Published: 23 February 2024
... of adipogenic potential in adipose stem cells, or impairment of adipogenesis is now recognised as an underlying cause of adipose tissue dysfunction and is associated with metabolic disease. In this study, we sought to determine the role of AMP-activated protein kinase (AMPK), an evolutionarily conserved master...
Includes: Supplementary data
Articles
Articles
Biochem J (2023) 480 (1): 105–125.
Published: 13 January 2023
...Manuel Johanns; Louis Hue; Mark H. Rider Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of AMPK...
Articles
Articles
Articles
Articles
Biochem J (2021) 478 (3): 633–646.
Published: 12 February 2021
...Franziska Kopietz; Yazeed Alshuweishi; Silvia Bijland; Fatmah Alghamdi; Eva Degerman; Kei Sakamoto; Ian P. Salt; Olga Göransson Activation of AMP-activated protein kinase (AMPK) is considered a valid strategy for the treatment of type 2 diabetes. However, despite the importance of adipose tissue...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (17): 3453–3469.
Published: 17 September 2020
...Katrin Spengler; Darya Zibrova; Angela Woods; Christopher G. Langendorf; John W. Scott; David Carling; Regine Heller Activation of AMP-activated protein kinase (AMPK) in endothelial cells by vascular endothelial growth factor (VEGF) via the Ca 2+ /calmodulin-dependent protein kinase kinase 2...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (12): 2347–2361.
Published: 26 June 2020
... with type 2 diabetes through mechanisms that are not fully understood. Canagliflozin has been shown to increase the activity of the AMP-activated protein kinase (AMPK), a metabolic energy sensor important for increasing fatty acid oxidation and energy expenditure and suppressing lipogenesis and inflammation...
Includes: Supplementary data
Articles
Articles
Biochem J (2020) 477 (12): 2237–2248.
Published: 24 June 2020
...Eri Matsumoto; Kaho Akiyama; Takuya Saito; Yu Matsumoto; Ken-Ichi Kobayashi; Jun Inoue; Yuji Yamamoto; Tsukasa Suzuki AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by inhibiting anabolic processes and activating catabolic processes. Recent studies have demonstrated...
Articles
In Collection
Adipose biology
Biochem J (2020) 477 (6): 1061–1081.
Published: 18 March 2020
... co-activator-1 alpha. While this review primarily focuses on mechanistic results from rodent studies special attention is given to the translation of these results, or lack thereof, to human physiology. AMPK exercise mice white adipose tissue Correspondence: Greg L. McKie ( gmckie...
Articles
Articles
Articles
Articles
Articles
Biochem J (2017) 474 (17): 3059–3073.
Published: 22 August 2017
...Robin Willows; Matthew J. Sanders; Bing Xiao; Bhakti R. Patel; Stephen R. Martin; Jon Read; Jon R. Wilson; Julia Hubbard; Steven J. Gamblin; David Carling AMP-activated protein kinase (AMPK) plays a major role in regulating metabolism and has attracted significant attention as a therapeutic target...
Articles
Biochem J (2017) 474 (10): 1741–1754.
Published: 09 May 2017
...Robin Willows; Naveenan Navaratnam; Ana Lima; Jon Read; David Carling AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. AMPK activation results in a wide range of downstream responses, many of which are associated with improved...
Articles
Biochem J (2017) 474 (9): 1453–1466.
Published: 13 April 2017
...-activated protein kinase (AMPK), at the lysosome and how both AMPK and mTORC1 signalling pathways feedback to lysosomal biogenesis and regeneration following autophagy. This review will cover the classical role of the lysosome in autophagy, the dynamic signalling interactions which take place...
Articles
Biochem J (2017) 474 (7): 1289–1292.
Published: 23 March 2017
... of energy in all cells. A key sensor of cellular energy is the adenosine-5′-monophosphate (AMP)-activated protein kinase (AMPK), which is the core component of a signaling network that regulates energy and nutrient metabolism. AMPK is activated by metabolic stresses that decrease cellular ATP, and functions...
Articles
Biochem J (2017) 474 (6): 983–1001.
Published: 07 March 2017
...Darya Zibrova; Franck Vandermoere; Olga Göransson; Mark Peggie; Karina V. Mariño; Anne Knierim; Katrin Spengler; Cora Weigert; Benoit Viollet; Nicholas A. Morrice; Kei Sakamoto; Regine Heller Activation of AMP-activated protein kinase (AMPK) in endothelial cells regulates energy homeostasis, stress...
Includes: Supplementary data
Articles
Articles
Biochem J (2017) 474 (1): 149–162.
Published: 22 December 2016
... for their oxidation remains unknown. We examined, in isolated muscle and cardiac myocytes, whether leptin, via AMP-activated protein kinase (AMPK) activation, stimulated fatty acid translocase (FAT/CD36)-mediated fatty acid uptake to enhance fatty acid oxidation. In both mouse skeletal muscle and rat cardiomyocytes...
Articles
Biochem J (2016) 473 (24): 4681–4697.
Published: 09 December 2016
...Helen R. Heathcote; Sarah J. Mancini; Anastasiya Strembitska; Kunzah Jamal; James A. Reihill; Timothy M. Palmer; Gwyn W. Gould; Ian P. Salt The key metabolic regulator, AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (19): 3013–3030.
Published: 27 September 2016
... including hypoxia inducible factor-1α (HIF-1α) and LDHA was decreased by CD44 silencing. These effects were due to the up-regulation of liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK)α activity by reduction in c-Src and Akt activity in CD44 knock-down cells. Finally, induction of LKB1/AMPKα...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (17): 2687–2689.
Published: 30 August 2016
...Ken D. O'Halloran AMP-activated protein kinase (AMPK) is pivotal to metabolic homoeostasis in eukaryotes, serving as a critical energy sensor. Increased AMPK activity during oxygen deprivation (hypoxia) protects against potentially catastrophic deficits in ATP supply. Although the nervous system...
Articles
Biochem J (2003) 370 (3): 1027–1032.
Published: 15 March 2003
... benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD.fmk) blocks apoptosis. Furthermore, AICAriboside induces mitochondrial cytochrome c release. AICAriboside, when phosphorylated to AICAribotide (ZMP), is a specific activator of the AMP-activated protein kinase (AMPK) in certain cell types. However...