...Manuel Johanns; Louis Hue; Mark H. Rider Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of AMPK...

...; Jonathan S. Oakhill; Christopher G. Langendorf The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity for new...

...Sheng-Ju Chuang; Manuel Johanns; Sébastien Pyr dit Ruys; Gregory R. Steinberg; Bruce E. Kemp; Benoît Viollet; Mark H. Rider The effects of small-molecule AMP-activated protein kinase (AMPK) activators in rat epididymal adipocytes were compared. SC4 was the most effective and submaximal doses of SC4...

... of the autophagy initiator kinase ULK1, has recently been reported as a more potent and selective AMP-activated protein kinase (AMPK) inhibitor relative to the widely used, but promiscuous inhibitor Compound C/Dorsomorphin. Here, we studied the effects of SBI-0206965 on AMPK signalling and metabolic readouts...

...Franziska Kopietz; Yazeed Alshuweishi; Silvia Bijland; Fatmah Alghamdi; Eva Degerman; Kei Sakamoto; Ian P. Salt; Olga Göransson Activation of AMP-activated protein kinase (AMPK) is considered a valid strategy for the treatment of type 2 diabetes. However, despite the importance of adipose tissue...

...Katrin Spengler; Darya Zibrova; Angela Woods; Christopher G. Langendorf; John W. Scott; David Carling; Regine Heller Activation of AMP-activated protein kinase (AMPK) in endothelial cells by vascular endothelial growth factor (VEGF) via the Ca 2+ /calmodulin-dependent protein kinase kinase 2...

... with type 2 diabetes through mechanisms that are not fully understood. Canagliflozin has been shown to increase the activity of the AMP-activated protein kinase (AMPK), a metabolic energy sensor important for increasing fatty acid oxidation and energy expenditure and suppressing lipogenesis and inflammation...

... resistance models. The results suggested that DhHP-6 decreased blood glucose, increased antioxidant enzyme activity, and inhibited glycogen synthesis in T2DM mice. In addition, DhHP-6 improved insulin resistance by activating phosphatidylinositol 3-kinase (PI3K)/AKT, and AMP-activated protein kinase (AMPK...

...Eri Matsumoto; Kaho Akiyama; Takuya Saito; Yu Matsumoto; Ken-Ichi Kobayashi; Jun Inoue; Yuji Yamamoto; Tsukasa Suzuki AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by inhibiting anabolic processes and activating catabolic processes. Recent studies have demonstrated...

... 2 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 AMPK exercise mice white adipose tissue Historically, white adipose tissue (i.e. WAT) was disregarded in the field of exercise biochemistry based on false assumptions...

... , were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated. Compound 1 was identified as artelasticin by high-resolution electrospray ionization mass spectrometry and 2D-NMR...

... associated proteins, several of which co-vary with CIP2A level. Many of these CIP2A associating and co-varying proteins are involved in energy metabolism including OXPHOS, or in 5′ AMP-activated protein kinase (AMPK) signalling, and manipulating AMPK activity mimics the effects of low/high CIP2A on OXPHOS...

...Omar J. Katwan; Fatmah Alghamdi; Tarek A. Almabrouk; Sarah J. Mancini; Simon Kennedy; Jonathan S. Oakhill; John W. Scott; Ian P. Salt AMP-activated protein kinase (AMPK) is a heterotrimer of α-catalytic and β- and γ-regulatory subunits that acts to regulate cellular and whole-body nutrient...

...Elaine C. Thomas; Sharon C. Hook; Alexander Gray; Alexandra Chadt; David Carling; Hadi Al-Hasani; Kate J. Heesom; D. Grahame Hardie; Jeremy M. Tavaré AMP-activated protein kinase (AMPK) is a key regulator of cellular and systemic energy homeostasis which achieves this through the phosphorylation...

...Robin Willows; Matthew J. Sanders; Bing Xiao; Bhakti R. Patel; Stephen R. Martin; Jon Read; Jon R. Wilson; Julia Hubbard; Steven J. Gamblin; David Carling AMP-activated protein kinase (AMPK) plays a major role in regulating metabolism and has attracted significant attention as a therapeutic target...

...Robin Willows; Naveenan Navaratnam; Ana Lima; Jon Read; David Carling AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. AMPK activation results in a wide range of downstream responses, many of which are associated with improved...

...-activated protein kinase (AMPK), at the lysosome and how both AMPK and mTORC1 signalling pathways feedback to lysosomal biogenesis and regeneration following autophagy. This review will cover the classical role of the lysosome in autophagy, the dynamic signalling interactions which take place...

... of energy in all cells. A key sensor of cellular energy is the adenosine-5′-monophosphate (AMP)-activated protein kinase (AMPK), which is the core component of a signaling network that regulates energy and nutrient metabolism. AMPK is activated by metabolic stresses that decrease cellular ATP, and functions...

...Darya Zibrova; Franck Vandermoere; Olga Göransson; Mark Peggie; Karina V. Mariño; Anne Knierim; Katrin Spengler; Cora Weigert; Benoit Viollet; Nicholas A. Morrice; Kei Sakamoto; Regine Heller Activation of AMP-activated protein kinase (AMPK) in endothelial cells regulates energy homeostasis, stress...

... could be regulated by the intermediate filaments, and whether AMP-activated protein kinase (AMPK) could be involved in this process. Chemical disruption (3,3′-iminodipropionitrile, IDPN) of the intermediate filaments did not alter mitochondrial respiration or sensitivity for numerous substrates...

... for their oxidation remains unknown. We examined, in isolated muscle and cardiac myocytes, whether leptin, via AMP-activated protein kinase (AMPK) activation, stimulated fatty acid translocase (FAT/CD36)-mediated fatty acid uptake to enhance fatty acid oxidation. In both mouse skeletal muscle and rat cardiomyocytes...

...Helen R. Heathcote; Sarah J. Mancini; Anastasiya Strembitska; Kunzah Jamal; James A. Reihill; Timothy M. Palmer; Gwyn W. Gould; Ian P. Salt The key metabolic regulator, AMP-activated protein kinase (AMPK), is reported to be down-regulated in metabolic disorders, but the mechanisms are poorly...

... including hypoxia inducible factor-1α (HIF-1α) and LDHA was decreased by CD44 silencing. These effects were due to the up-regulation of liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK)α activity by reduction in c-Src and Akt activity in CD44 knock-down cells. Finally, induction of LKB1/AMPKα...

...Ken D. O'Halloran AMP-activated protein kinase (AMPK) is pivotal to metabolic homoeostasis in eukaryotes, serving as a critical energy sensor. Increased AMPK activity during oxygen deprivation (hypoxia) protects against potentially catastrophic deficits in ATP supply. Although the nervous system...

... benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD.fmk) blocks apoptosis. Furthermore, AICAriboside induces mitochondrial cytochrome c release. AICAriboside, when phosphorylated to AICAribotide (ZMP), is a specific activator of the AMP-activated protein kinase (AMPK) in certain cell types. However...