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Articles

Development of an OTUD1 ubiquitin variant inhibitor

Qi Liu, Evan Mallette, Hui Zheng, Wei Zhang
Journal: Biochemical Journal
Biochem J (2023) 480 (16): 1317–1330.
https://doi.org/10.1042/BCJ20230119
Published: 25 August 2023
View article titled, Development of an OTUD1 ubiquitin variant inhibitor
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Includes: Supplementary data
Articles

Unlocking the secrets of the microbiome: exploring the dynamic microbial interplay with humans through metabolomics and their manipulation for synthetic biology applications

In Collection
Towards systems biochemistry
Howbeer Muhamadali, Catherine L. Winder, Warwick B. Dunn, Royston Goodacre
Journal: Biochemical Journal
Biochem J (2023) 480 (12): 891–908.
https://doi.org/10.1042/BCJ20210534
Published: 28 June 2023
View article titled, Unlocking the secrets of the microbiome: exploring the dynamic microbial interplay with humans through metabolomics and their manipulation for synthetic biology applications
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Articles

Structural features of sensory two component systems: a synthetic biology perspective

Marcos Nieves, Alejandro Buschiazzo, Felipe Trajtenberg
Journal: Biochemical Journal
Biochem J (2023) 480 (2): 127–140.
https://doi.org/10.1042/BCJ20210798
Published: 23 January 2023
View article titled, Structural features of sensory two component systems: a synthetic biology perspective
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Articles

Proteomic mapping and optogenetic manipulation of membrane contact sites

Gang Lin, Wenyi Shi, Ningxia Zhang, Yi-Tsang Lee, Youjun Wang, Ji Jing
Journal: Biochemical Journal
Biochem J (2022) 479 (17): 1857–1875.
https://doi.org/10.1042/BCJ20220382
Published: 16 September 2022
View article titled, Proteomic mapping and optogenetic manipulation of membrane contact sites
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Articles

Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure

Hossein Allahmoradi, S. Mohsen Asghari, Atieh Ahmadi, Elham Assareh, Mahboobeh Nazari
Journal: Biochemical Journal
Biochem J (2022) 479 (12): 1285–1302.
https://doi.org/10.1042/BCJ20210830
Published: 21 June 2022
View article titled, Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure
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Includes: Supplementary data
Articles

Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system

Johanna Maarit Koivisto, Nina Rødtness Poulsen, Benedikte Stoklund Larsen, M.G.M. Weibull, Amelie Stein, Fabio Doro, Jakob Rahr Winther, Kresten Lindorff-Larsen, Martin Willemoës
Journal: Biochemical Journal
Biochem J (2022) 479 (4): 479–501.
https://doi.org/10.1042/BCJ20210767
Published: 17 February 2022
View article titled, Co-evolution of drug resistance and broadened substrate recognition in HIV protease variants isolated from an Escherichia coli genetic selection system
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Includes: Supplementary data
Articles

Stepwise oxidations play key roles in the structural and functional regulations of DJ-1

In-Kang Song, Mi-Sun Kim, James E. Ferrell Jr., Dong-Hae Shin, Kong-Joo Lee
Journal: Biochemical Journal
Biochem J (2021) 478 (19): 3505–3525.
https://doi.org/10.1042/BCJ20210245
Published: 06 October 2021
View article titled, Stepwise oxidations play key roles in the structural and functional regulations of DJ-1
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Includes: Supplementary data
Articles

Investigation of sequon engineering for improved O-glycosylation by the human polypeptide N-acetylgalactosaminyl transferase T2 isozyme and two orthologues

Nicole K. Thompson, Leif T. N. LeClaire, Samantha Rodriguez Perez, Warren W. Wakarchuk
Journal: Biochemical Journal
Biochem J (2021) 478 (19): 3527–3537.
https://doi.org/10.1042/BCJ20210382
Published: 06 October 2021
View article titled, Investigation of sequon engineering for improved O-glycosylation by the human polypeptide N-acetylgalactosaminyl transferase T2 isozyme and two orthologues
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Includes: Supplementary data
Articles

Activation by NarL at the Escherichia coli ogt promoter

Patcharawarin Ruanto, David L. Chismon, Joanne Hothersall, Rita E. Godfrey, David J. Lee, Stephen J. W. Busby, Douglas F. Browning
Journal: Biochemical Journal
Biochem J (2020) 477 (15): 2807–2820.
https://doi.org/10.1042/BCJ20200408
Published: 07 August 2020
View article titled, Activation by NarL at the Escherichia coli ogt promoter
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Includes: Supplementary data
Articles

Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli

Jenelle A. Patterson, Hai He, Jacob S. Folz, Qiang Li, Mark A. Wilson, Oliver Fiehn, Steven D. Bruner, Arren Bar-Even, Andrew D. Hanson
Journal: Biochemical Journal
Biochem J (2020) 477 (9): 1745–1757.
https://doi.org/10.1042/BCJ20200198
Published: 15 May 2020
View article titled, Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli
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Includes: Supplementary data
Articles

Genetic evidences for the core biosynthesis pathway, regulation, transport and secretion of liamocins in yeast-like fungal cells

Si-Jia Xue, Guang-Lei Liu, Zhe Chi, Zhi-Chao Gao, Zhong Hu, Zhen-Ming Chi
Journal: Biochemical Journal
Biochem J (2020) 477 (5): 887–903.
https://doi.org/10.1042/BCJ20190922
Published: 04 March 2020
View article titled, Genetic evidences for the core biosynthesis pathway, regulation, transport and secretion of liamocins in yeast-like fungal cells
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Includes: Supplementary data
Articles

Rational engineering of a malate dehydrogenase for microbial production of 2,4-dihydroxybutyric acid via homoserine pathway

Cláudio J.R. Frazão, Christopher M. Topham, Yoann Malbert, Jean Marie François, Thomas Walther
Journal: Biochemical Journal
Biochem J (2018) 475 (23): 3887–3901.
https://doi.org/10.1042/BCJ20180765
Published: 12 December 2018
View article titled, Rational engineering of a malate dehydrogenase for microbial production of 2,4-dihydroxybutyric acid via homoserine pathway
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Includes: Supplementary data
Articles

Eudesmane-type sesquiterpene diols directly synthesized by a sesquiterpene cyclase in Tripterygium wilfordii

Yu-ru Tong, Ping Su, Hong-yu Guan, Tian-yuan Hu, Jin-long Chen, Yi-feng Zhang, Yu-jun Zhao, Lin-hui Gao, Xia-nan Zhang, Lu-qi Huang, Wei Gao
Journal: Biochemical Journal
Biochem J (2018) 475 (17): 2713–2725.
https://doi.org/10.1042/BCJ20180353
Published: 05 September 2018
View article titled, Eudesmane-type sesquiterpene diols directly synthesized by a sesquiterpene cyclase in Tripterygium wilfordii
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Includes: Supplementary data
Articles

CRISPR base editors: genome editing without double-stranded breaks

In Collection
Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019
Ayman Eid, Sahar Alshareef, Magdy M. Mahfouz
Journal: Biochemical Journal
Biochem J (2018) 475 (11): 1955–1964.
https://doi.org/10.1042/BCJ20170793
Published: 11 June 2018
View article titled, CRISPR base editors: genome editing without double-stranded breaks
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Articles

Holistic bioengineering: rewiring central metabolism for enhanced bioproduction

Selçuk Aslan, Elad Noor, Arren Bar-Even
Journal: Biochemical Journal
Biochem J (2017) 474 (23): 3935–3950.
https://doi.org/10.1042/BCJ20170377
Published: 16 November 2017
View article titled, Holistic bioengineering: rewiring central metabolism for enhanced bioproduction
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Articles

Effect of position-specific single-point mutations and biophysical characterization of amyloidogenic peptide fragments identified from lattice corneal dystrophy patients

Venkatraman Anandalakshmi, Elavazhagan Murugan, Eunice Goh Tze Leng, Lim Wei Ting, Shyam S. Chaurasia, Toshio Yamazaki, Toshio Nagashima, Benjamin Lawrence George, Gary Swee Lim Peh, Konstantin Pervushin, Rajamani Lakshminarayanan, Jodhbir S. Mehta
Journal: Biochemical Journal
Biochem J (2017) 474 (10): 1705–1725.
https://doi.org/10.1042/BCJ20170125
Published: 09 May 2017
View article titled, Effect of position-specific single-point mutations and biophysical characterization of amyloidogenic peptide fragments identified from lattice corneal dystrophy patients
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Includes: Supplementary data
Articles

Reengineering of the human pyruvate dehydrogenase complex: from disintegration to highly active agglomerates

Jin Guo, Samira Hezaveh, Jana Tatur, An-Ping Zeng, Uwe Jandt
Journal: Biochemical Journal
Biochem J (2017) 474 (5): 865–875.
https://doi.org/10.1042/BCJ20160916
Published: 20 February 2017
View article titled, Reengineering of the human pyruvate dehydrogenase complex: from disintegration to highly active agglomerates
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Includes: Supplementary data
Articles

Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the ‘retro’ approach to protein engineering

Yosephine Gumulya, Elizabeth M.J. Gillam
Journal: Biochemical Journal
Biochem J (2017) 474 (1): 1–19.
https://doi.org/10.1042/BCJ20160507
Published: 22 December 2016
View article titled, Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the ‘retro’ approach to protein engineering
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Articles

Secondary structure model of the naked segment 7 influenza A virus genomic RNA

Agnieszka Ruszkowska, Elzbieta Lenartowicz, Walter N. Moss, Ryszard Kierzek, Elzbieta Kierzek
Journal: Biochemical Journal
Biochem J (2016) 473 (23): 4327–4348.
https://doi.org/10.1042/BCJ20160651
Published: 25 November 2016
View article titled, Secondary structure model of the naked segment 7 influenza A virus genomic RNA
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Includes: Supplementary data
Articles

Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design

Gary G.A. Silkstone, Rebecca S. Silkstone, Michael T. Wilson, Michelle Simons, Leif Bülow, Kristian Kallberg, Khuanpiroon Ratanasopa, Luca Ronda, Andrea Mozzarelli, Brandon J. Reeder, Chris E. Cooper
Journal: Biochemical Journal
Biochem J (2016) 473 (19): 3371–3383.
https://doi.org/10.1042/BCJ20160243
Published: 27 September 2016
View article titled, Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design
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