Page 1 | Search Results | Biochemical Journal

1-50 of 384

Sort by

Sort Order Select

Articles

Chemical biology tools for protein labelling: insights into cell–cell communication

Megan H. Wright

Biochem J (2023) 480 (18): 1445–1457.

https://doi.org/10.1042/BCJ20220309

Published: 21 September 2023

View article titled, Chemical biology tools for protein labelling: insights into cell–cell communication

Articles

How many kinases are druggable? A review of our current understanding

Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W. Davis-Gilbert, David H. Drewry

Biochem J (2023) 480 (16): 1331–1363.

https://doi.org/10.1042/BCJ20220217

Published: 29 August 2023

View article titled, How many kinases are druggable? A review of our current understanding

Includes: Supplementary data

Articles

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

In Collection

Cell signaling in the 21st century

Alexander C. Jones, Alexandr P. Kornev, Jui-Hung Weng, Gerard Manning, Susan S. Taylor, Alexandra C. Newton

Biochem J (2023) 480 (16): 1299–1316.

https://doi.org/10.1042/BCJ20220397

Published: 25 August 2023

View article titled, Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

Includes: Supplementary data

Articles

Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues

Kyler A. Weingartner, Thao Tran, Katherine W. Tripp, Jennifer M. Kavran

Biochem J (2023) 480 (15): 1165–1182.

https://doi.org/10.1042/BCJ20230067

Published: 27 July 2023

View article titled, Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues

Includes: Supplementary data

Articles

RhoGAP6 interacts with COPI to regulate protein transport

Lorna O'Donoghue, Shane P. Comer, Dishon W. Hiebner, Ingmar Schoen, Alex von Kriegsheim, Albert Smolenski

Biochem J (2023) 480 (14): 1109–1127.

https://doi.org/10.1042/BCJ20230013

Published: 19 July 2023

View article titled, RhoGAP6 interacts with COPI to regulate protein transport

Articles

Calcium signalling components underlying NPK homeostasis: potential avenues for exploration

In Collection

Plants and climate change: the role of plants in achieving net zero

Sonam Pahuja, Malathi Bheri, Diksha Bisht, Girdhar K. Pandey

Biochem J (2023) 480 (13): 1015–1034.

https://doi.org/10.1042/BCJ20230156

Published: 07 July 2023

View article titled, Calcium signalling components underlying NPK homeostasis: potential avenues for exploration

Articles

Shaping mitochondria through fed–fast and circadian cycles

In Collection

Cell signaling in the 21st century

Subhash Khatri, Rubina Kazi, Ullas Kolthur-Seetharam

Biochem J (2023) 480 (13): 909–919.

https://doi.org/10.1042/BCJ20220378

Published: 04 July 2023

View article titled, Shaping mitochondria through fed–fast and circadian cycles

Articles

Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI

In Collection

Cell signaling in the 21st century

Mitchell H. Omar, Maryanne Kihiu, Dominic P. Byrne, Kyung-Soon Lee, Tyler M. Lakey, Erik Butcher, Patrick A. Eyers, John D. Scott

Biochem J (2023) 480 (12): 875–890.

https://doi.org/10.1042/BCJ20230183

Published: 22 June 2023

View article titled, Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI

Articles

Paradigms of receptor kinase signaling in plants

In Collection

Cell signaling in the 21st century

Kyle W. Bender, Cyril Zipfel

Biochem J (2023) 480 (12): 835–854.

https://doi.org/10.1042/BCJ20220372

Published: 16 June 2023

View article titled, Paradigms of receptor kinase signaling in plants

Articles

Root system growth and development responses to elevated CO 2 : underlying signalling mechanisms and role in improving plant CO 2 capture and soil C storage

In Collection

Plants and climate change: the role of plants in achieving net zero

Liên Bach, Alain Gojon

Biochem J (2023) 480 (11): 753–771.

https://doi.org/10.1042/BCJ20220245

Published: 02 June 2023

View article titled, Root system growth and development responses to elevated CO 2 : underlying signalling mechanisms and role in improving plant CO 2 capture and soil C storage

Articles

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

A. Jane Bardwell, Madhuri Paul, Kiku C. Yoneda, María D. Andrade-Ludeña, Oanh T. Nguyen, David A. Fruman, Lee Bardwell

Biochem J (2023) 480 (10): 729–750.

https://doi.org/10.1042/BCJ20220493

Published: 26 May 2023

View article titled, The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

Articles

Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia

W. Bruce Sneddon, Peter A. Friedman, Tatyana Mamonova

Biochem J (2023) 480 (9): 685–699.

https://doi.org/10.1042/BCJ20230020

Published: 17 May 2023

View article titled, Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia

Articles

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

In Collection

Cell signaling in the 21st century

Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook

Biochem J (2023) 480 (9): 587–605.

https://doi.org/10.1042/BCJ20220598

Published: 04 May 2023

View article titled, ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

Includes: Supplementary data

Articles

Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis

In Collection

Plants and climate change: the role of plants in achieving net zero

Lokesh K. Saini, Manisha Sharma, Barkha Ravi, Soma Ghosh, Sonam Pahuja, Nidhi Singh, Girdhar K. Pandey

Biochem J (2023) 480 (9): 555–571.

https://doi.org/10.1042/BCJ20230026

Published: 28 April 2023

View article titled, Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis

Articles

Principles of phosphoproteomics and applications in cancer research

In Collection

Cell signaling in the 21st century

Luke Higgins, Henry Gerdes, Pedro R. Cutillas

Biochem J (2023) 480 (6): 403–420.

https://doi.org/10.1042/BCJ20220220

Published: 24 March 2023

View article titled, Principles of phosphoproteomics and applications in cancer research

Articles

Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Edwin T. Gibbs, II, Chad A. Lerner, Mark A. Watson, Hoi-Shan Wong, Akos A. Gerencser, Martin D. Brand

Biochem J (2023) 480 (5): 363–384.

https://doi.org/10.1042/BCJ20220611

Published: 15 March 2023

View article titled, Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Articles

Macropinocytosis: mechanisms and regulation

Gilbert Salloum, Anne R. Bresnick, Jonathan M. Backer

Biochem J (2023) 480 (5): 335–362.

https://doi.org/10.1042/BCJ20210584

Published: 15 March 2023

View article titled, Macropinocytosis: mechanisms and regulation

Includes: Multimedia, Supplementary data

Articles

Protein kinase C showcases allosteric control: activation of LRRK1

Hannah Tovell, Alexandra C. Newton

Biochem J (2023) 480 (3): 219–223.

https://doi.org/10.1042/BCJ20220507

Published: 10 February 2023

View article titled, Protein kinase C showcases allosteric control: activation of LRRK1

Articles

BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

In Collection

Cell death and survival

Gabriela Brumatti, Deeksha Kaloni, Fabíola Attié Castro, Gustavo P. Amarante-Mendes

Biochem J (2023) 480 (2): 161–176.

https://doi.org/10.1042/BCJ20210608

Published: 31 January 2023

View article titled, BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

Articles

Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

In Collection

Cell signaling in the 21st century

Dominic P. Byrne, Safal Shrestha, Leonard A. Daly, Vanessa Marensi, Krithika Ramakrishnan, Claire E. Eyers, Natarajan Kannan, Patrick A. Eyers

Biochem J (2023) 480 (2): 141–160.

https://doi.org/10.1042/BCJ20220474

Published: 23 January 2023

View article titled, Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

Includes: Multimedia, Supplementary data

Articles

Structural features of sensory two component systems: a synthetic biology perspective

Marcos Nieves, Alejandro Buschiazzo, Felipe Trajtenberg

Biochem J (2023) 480 (2): 127–140.

https://doi.org/10.1042/BCJ20210798

Published: 23 January 2023

View article titled, Structural features of sensory two component systems: a synthetic biology perspective

Articles

Characterizing crosstalk in epigenetic signaling to understand disease physiology

In Collection

Cell signaling in the 21st century

Joanna K. Lempiäinen, Benjamin A. Garcia

Biochem J (2023) 480 (1): 57–85.

https://doi.org/10.1042/BCJ20220550

Published: 11 January 2023

View article titled, Characterizing crosstalk in epigenetic signaling to understand disease physiology

Articles

Dynamic regulation of RAS and RAS signaling

In Collection

Cell signaling in the 21st century

Walter Kolch, Dénes Berta, Edina Rosta

Biochem J (2023) 480 (1): 1–23.

https://doi.org/10.1042/BCJ20220234

Published: 06 January 2023

View article titled, Dynamic regulation of RAS and RAS signaling

Articles

Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity

Foteini Bartzoka, Monica Gonzalez-Magaldi, Patrick O. Byrne, Nicole I. Callery, Kalina Hristova, Daniel J. Leahy

Biochem J (2022) 479 (24): 2465–2475.

https://doi.org/10.1042/BCJ20220472

Published: 19 December 2022

View article titled, Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity

Includes: Supplementary data

Articles

Regulation of B cell receptor signalling by Epstein–Barr virus nuclear antigens

Sarika Khasnis, Hildegonda Veenstra, Michael J. McClellan, Opeoluwa Ojeniyi, C. David Wood, Michelle J. West

Biochem J (2022) 479 (23): 2395–2417.

https://doi.org/10.1042/BCJ20220417

Published: 07 December 2022

View article titled, Regulation of B cell receptor signalling by Epstein–Barr virus nuclear antigens

Includes: Supplementary data

Articles

Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner

Enoli De Silva, Dana V. Devine, Eric Jan, Calvin D. Roskelley, Hugh Kim

Biochem J (2022) 479 (22): 2351–2364.

https://doi.org/10.1042/BCJ20220177

Published: 23 November 2022

View article titled, Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner

Includes: Supplementary data

Articles

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

In Collection

Awards

D. Grahame Hardie

Biochem J (2022) 479 (22): 2327–2343.

https://doi.org/10.1042/BCJ20220255

Published: 16 November 2022

View article titled, AMP-activated protein kinase — a journey from 1 to 100 downstream targets

Articles

PI(4,5)P 2 : signaling the plasma membrane

Rachel C. Wills, Gerald R. V. Hammond

Biochem J (2022) 479 (21): 2311–2325.

https://doi.org/10.1042/BCJ20220445

Published: 11 November 2022

View article titled, PI(4,5)P 2 : signaling the plasma membrane

Articles

Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes

Su-Ping Ng, Wataru Nomura, Haruya Takahashi, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto, Yoshiharu Inoue

Biochem J (2022) 479 (21): 2279–2296.

https://doi.org/10.1042/BCJ20220271

Published: 04 November 2022

View article titled, Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes

Includes: Supplementary data

Articles

Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Qian Wei, Kjetil Taskén

Biochem J (2022) 479 (20): 2219–2260.

https://doi.org/10.1042/BCJ20210233

Published: 28 October 2022

View article titled, Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Articles

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen

Biochem J (2022) 479 (20): 2195–2216.

https://doi.org/10.1042/BCJ20220401

Published: 21 October 2022

View article titled, Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Includes: Supplementary data

Articles

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Biochem J (2022) 479 (19): 2087–2113.

https://doi.org/10.1042/BCJ20220089

Published: 14 October 2022

View article titled, Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Includes: Supplementary data

Articles

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Biochem J (2022) 479 (19): 2063–2086.

https://doi.org/10.1042/BCJ20220102

Published: 14 October 2022

View article titled, Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Includes: Supplementary data

Articles

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Jill E. Hunter, Amy E. Campbell, Scott Kerridge, Callum Fraser, Nicola L. Hannaway, Saimir Luli, Iglika Ivanova, Philip J. Brownridge, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S. R. Hasoon, Claire E. Eyers, Neil D. Perkins

Biochem J (2022) 479 (19): 2131–2151.

https://doi.org/10.1042/BCJ20220103

Published: 14 October 2022

View article titled, Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Includes: Supplementary data

Articles

Mechanisms of TNF-independent RIPK3-mediated cell death

Bart Tummers, Douglas R. Green

Biochem J (2022) 479 (19): 2049–2062.

https://doi.org/10.1042/BCJ20210724

Published: 14 October 2022

View article titled, Mechanisms of TNF-independent RIPK3-mediated cell death

Articles

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Deep Chatterjee, Toan K. Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R. Alessi

Biochem J (2022) 479 (18): 1941–1965.

https://doi.org/10.1042/BCJ20220308

Published: 23 September 2022

View article titled, PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Articles

Combinatorial approaches for mitigating resistance to KRAS-targeted therapies

Hannah R. Warren, Sarah J. Ross, Paul D. Smith, Judy M. Coulson, Ian A. Prior

Biochem J (2022) 479 (18): 1985–1997.

https://doi.org/10.1042/BCJ20220440

Published: 23 September 2022

View article titled, Combinatorial approaches for mitigating resistance to KRAS-targeted therapies

Includes: Supplementary data

Articles

TOR complex 2 is a master regulator of plasma membrane homeostasis

In Collection

Awards

Jeremy Thorner

Biochem J (2022) 479 (18): 1917–1940.

https://doi.org/10.1042/BCJ20220388

Published: 23 September 2022

View article titled, TOR complex 2 is a master regulator of plasma membrane homeostasis

Includes: Supplementary data

Articles

Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain

Pravin S. Dewangan, Tsebaot G. Beraki, E. Ariana Paiz, Delia Appiah Mensah, Zhe Chen, Michael L. Reese

Biochem J (2022) 479 (17): 1877–1889.

https://doi.org/10.1042/BCJ20220076

Published: 16 September 2022

View article titled, Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain

Includes: Supplementary data

Articles

TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells

Melissa Rodrigues, Tsvetana Petrova, Brendan Tibbs, J. Simon C. Arthur, Philip Cohen

Biochem J (2022) 479 (17): 1891–1907.

https://doi.org/10.1042/BCJ20220314

Published: 16 September 2022

View article titled, TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells

Includes: Supplementary data

Articles

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Alexia F. Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther Sammler, Dario R. Alessi

Biochem J (2022) 479 (17): 1759–1783.

https://doi.org/10.1042/BCJ20220161

Published: 06 September 2022

View article titled, Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Includes: Supplementary data

Articles

Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth

Ksenija Korac, Devaraja Rajasekaran, Tyler Sniegowski, Bradley K. Schniers, Andrew F. Ibrahim, Yangzom D. Bhutia

Biochem J (2022) 479 (17): 1807–1824.

https://doi.org/10.1042/BCJ20210851

Published: 06 September 2022

View article titled, Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth

Includes: Supplementary data

Articles

Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

Gavuthami Murugesan, Alan R. Prescott, Rachel Toth, David G. Campbell, Claire M. Wells, Carol MacKintosh

Biochem J (2022) 479 (16): 1709–1725.

https://doi.org/10.1042/BCJ20220184

Published: 31 August 2022

View article titled, Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

Includes: Supplementary data

Articles

Cell death in skin function, inflammation, and disease

In Collection

Cell death and survival

Holly Anderton, Suhaib Alqudah

Biochem J (2022) 479 (15): 1621–1651.

https://doi.org/10.1042/BCJ20210606

Published: 05 August 2022

View article titled, Cell death in skin function, inflammation, and disease

Articles

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

Biochem J (2022) 479 (13): 1467–1486.

https://doi.org/10.1042/BCJ20220281

Published: 12 July 2022

View article titled, PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

Includes: Multimedia, Supplementary data

Articles

Deciphering signal transduction networks in the liver by mechanistic mathematical modelling

In Collection

Towards systems biochemistry

Lorenza A. D’Alessandro, Ursula Klingmüller, Marcel Schilling

Biochem J (2022) 479 (12): 1361–1374.

https://doi.org/10.1042/BCJ20210548

Published: 24 June 2022

View article titled, Deciphering signal transduction networks in the liver by mechanistic mathematical modelling

Articles

Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider

Biochem J (2022) 479 (12): 1317–1336.

https://doi.org/10.1042/BCJ20220170

Published: 22 June 2022

View article titled, Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators

Includes: Supplementary data

Articles

Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure

Hossein Allahmoradi, S. Mohsen Asghari, Atieh Ahmadi, Elham Assareh, Mahboobeh Nazari

Biochem J (2022) 479 (12): 1285–1302.

https://doi.org/10.1042/BCJ20210830

Published: 21 June 2022

View article titled, Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure

Includes: Supplementary data

Articles

Towards ‘end-to-end’ analysis and understanding of biological timecourse data

In Collection

Towards systems biochemistry

Siddhartha G. Jena, Alexander G. Goglia, Barbara E. Engelhardt

Biochem J (2022) 479 (11): 1257–1263.

https://doi.org/10.1042/BCJ20220053

Published: 17 June 2022

View article titled, Towards ‘end-to-end’ analysis and understanding of biological timecourse data

Articles

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

Xiaowen Duan, Dougall M. Norris, Sean J. Humphrey, Pengyi Yang, Kristen C. Cooke, Will P. Bultitude, Benjamin L. Parker, Olivia J. Conway, James G. Burchfield, James R. Krycer, Frances M. Brodsky, David E. James, Daniel J. Fazakerley

Biochem J (2022) 479 (11): 1237–1256.

https://doi.org/10.1042/BCJ20220153

Published: 13 June 2022

View article titled, Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

Includes: Supplementary data

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only