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Articles

Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia

W. Bruce Sneddon, Peter A. Friedman, Tatyana Mamonova

Biochem J (2023) 480 (9): 685–699.

DOI: https://doi.org/10.1042/BCJ20230020

Published: 17 May 2023

View article titled, Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemia

Articles

Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module

Ishita Bardhan, Soumen Barman, Anirban Roy, Babu Sudhamalla

Biochem J (2023) 480 (9): 629–647.

DOI: https://doi.org/10.1042/BCJ20230011

Published: 10 May 2023

View article titled, Novel insights into the recognition of acetylated histone H4 tail by the TRIM24 PHD-Bromo module

Includes: Supplementary data

Articles

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

In Collection

Cell signaling in the 21st century

Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook

Biochem J (2023) 480 (9): 587–605.

DOI: https://doi.org/10.1042/BCJ20220598

Published: 04 May 2023

View article titled, ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

Includes: Supplementary data

Articles

Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis

In Collection

Plants and climate change: the role of plants in achieving net zero

Lokesh K. Saini, Manisha Sharma, Barkha Ravi, Soma Ghosh, Sonam Pahuja, Nidhi Singh, Girdhar K. Pandey

Biochem J (2023) 480 (9): 555–571.

DOI: https://doi.org/10.1042/BCJ20230026

Published: 28 April 2023

View article titled, Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis

Articles

Protein kinase C showcases allosteric control: activation of LRRK1

Hannah Tovell, Alexandra C. Newton

Biochem J (2023) 480 (3): 219–223.

DOI: https://doi.org/10.1042/BCJ20220507

Published: 10 February 2023

View article titled, Protein kinase C showcases allosteric control: activation of LRRK1

Articles

Characterizing crosstalk in epigenetic signaling to understand disease physiology

In Collection

Cell signaling in the 21st century

Joanna K. Lempiäinen, Benjamin A. Garcia

Biochem J (2023) 480 (1): 57–85.

DOI: https://doi.org/10.1042/BCJ20220550

Published: 11 January 2023

View article titled, Characterizing crosstalk in epigenetic signaling to understand disease physiology

Articles

Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12

Elisha H. McCrory, Vyacheslav Akimov, Philip Cohen, Blagoy Blagoev

Biochem J (2022) 479 (23): 2419–2431.

DOI: https://doi.org/10.1042/BCJ20220510

Published: 07 December 2022

View article titled, Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12

Includes: Supplementary data

Articles

Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression

Misun Jung, Wonyoung Kim, Jin Won Cho, Won Ho Yang, In Kwon Chung

Biochem J (2022) 479 (22): 2379–2394.

DOI: https://doi.org/10.1042/BCJ20220391

Published: 30 November 2022

View article titled, Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression

Includes: Supplementary data

Articles

The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii

Micaela Cerletti, Agustín Rabino, Roberto A. Paggi, Celeste Ferrari, Ansgar Poetsch, Harri Savilahti, Saija Kiljunen, Rosana E. De Castro

Biochem J (2022) 479 (22): 2365–2377.

DOI: https://doi.org/10.1042/BCJ20220403

Published: 23 November 2022

View article titled, The C-terminal region of phytoene synthase is a key element to control carotenoid biosynthesis in the haloarchaeon Haloferax volcanii

Includes: Supplementary data

Articles

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

In Collection

Awards

D. Grahame Hardie

Biochem J (2022) 479 (22): 2327–2343.

DOI: https://doi.org/10.1042/BCJ20220255

Published: 16 November 2022

View article titled, AMP-activated protein kinase — a journey from 1 to 100 downstream targets

Articles

Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes

Su-Ping Ng, Wataru Nomura, Haruya Takahashi, Kazuo Inoue, Teruo Kawada, Tsuyoshi Goto, Yoshiharu Inoue

Biochem J (2022) 479 (21): 2279–2296.

DOI: https://doi.org/10.1042/BCJ20220271

Published: 04 November 2022

View article titled, Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1–p38–mTORC1 signaling axis in adipocytes

Includes: Supplementary data

Articles

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Jill E. Hunter, Amy E. Campbell, Scott Kerridge, Callum Fraser, Nicola L. Hannaway, Saimir Luli, Iglika Ivanova, Philip J. Brownridge, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S. R. Hasoon, Claire E. Eyers, Neil D. Perkins

Biochem J (2022) 479 (19): 2131–2151.

DOI: https://doi.org/10.1042/BCJ20220103

Published: 14 October 2022

View article titled, Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Includes: Supplementary data

Articles

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Deep Chatterjee, Toan K. Phung, Melanie Wightman, Robert Gourlay, Nick Morrice, Sebastian Mathea, Stefan Knapp, Dario R. Alessi

Biochem J (2022) 479 (18): 1941–1965.

DOI: https://doi.org/10.1042/BCJ20220308

Published: 23 September 2022

View article titled, PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

Articles

Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain

Pravin S. Dewangan, Tsebaot G. Beraki, E. Ariana Paiz, Delia Appiah Mensah, Zhe Chen, Michael L. Reese

Biochem J (2022) 479 (17): 1877–1889.

DOI: https://doi.org/10.1042/BCJ20220076

Published: 16 September 2022

View article titled, Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain

Includes: Supplementary data

Articles

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Alexia F. Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther Sammler, Dario R. Alessi

Biochem J (2022) 479 (17): 1759–1783.

DOI: https://doi.org/10.1042/BCJ20220161

Published: 06 September 2022

View article titled, Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Includes: Supplementary data

Articles

Common and unique features of glycosylation and glycosyltransferases in African trypanosomes

Samuel M. Duncan, Michael A.J. Ferguson

Biochem J (2022) 479 (17): 1743–1758.

DOI: https://doi.org/10.1042/BCJ20210778

Published: 06 September 2022

View article titled, Common and unique features of glycosylation and glycosyltransferases in African trypanosomes

Articles

NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes

Anne Carine Østvold, Kirsten Grundt, Claudia Wiese

Biochem J (2022) 479 (11): 1205–1220.

DOI: https://doi.org/10.1042/BCJ20220075

Published: 13 June 2022

View article titled, NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes

Articles

Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway

In Collection

Cell death and survival

Neil D. Perkins

Biochem J (2022) 479 (11): 1121–1126.

DOI: https://doi.org/10.1042/BCJ20220023

Published: 01 June 2022

View article titled, Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway

Articles

Deubiquitinases in cell death and inflammation

In Collection

Cell death and survival

Kim Newton, Alexander D. Gitlin

Biochem J (2022) 479 (10): 1103–1119.

DOI: https://doi.org/10.1042/BCJ20210735

Published: 24 May 2022

View article titled, Deubiquitinases in cell death and inflammation

Articles

Sialylation-dependent pharmacokinetics and differential complement pathway inhibition are hallmarks of CR1 activity in vivo

Biochem J (2022) 479 (9): 1007–1030.

DOI: https://doi.org/10.1042/BCJ20220054

Published: 13 May 2022

View article titled, Sialylation-dependent pharmacokinetics and differential complement pathway inhibition are hallmarks of CR1 activity in vivo

Includes: Supplementary data

Articles

RIP1 post-translational modifications

In Collection

Cell death and survival

Eugene Varfolomeev, Domagoj Vucic

Biochem J (2022) 479 (9): 929–951.

DOI: https://doi.org/10.1042/BCJ20210725

Published: 06 May 2022

View article titled, RIP1 post-translational modifications

Articles

LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin

Yuan Zhang, Min Zhu, Chunlei Zheng, Wei Wei, Brian T. Emmer, Bin Zhang

Biochem J (2022) 479 (7): 839–855.

DOI: https://doi.org/10.1042/BCJ20220055

Published: 11 April 2022

View article titled, LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin

Includes: Supplementary data

Articles

Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

Karen M. Dunkerley, Anne C. Rintala-Dempsey, Giulia Salzano, Roya Tadayon, Dania Hadi, Kathryn R. Barber, Helen Walden, Gary S. Shaw

Biochem J (2022) 479 (6): 751–766.

DOI: https://doi.org/10.1042/BCJ20210741

Published: 28 March 2022

View article titled, Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

Includes: Supplementary data

Articles

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Zhuoyao Chen, Jinwei Zhang, Adrián R. Murillo-de-Ozores, María Castañeda-Bueno, Francesca D'Amico, Raphael Heilig, Charlotte E. Manning, Fiona J. Sorrell, Vincenzo D'Angiolella, Roman Fischer, Monique P. C. Mulder, Gerardo Gamba, Dario R. Alessi, Alex N. Bullock

Biochem J (2022) 479 (5): 661–675.

DOI: https://doi.org/10.1042/BCJ20220019

Published: 04 March 2022

View article titled, Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Includes: Supplementary data

Articles

Beyond protein modification: the rise of non-canonical ADP-ribosylation

In Collection

Awards

Marion Schuller, Ivan Ahel

Biochem J (2022) 479 (4): 463–477.

DOI: https://doi.org/10.1042/BCJ20210280

Published: 17 February 2022

View article titled, Beyond protein modification: the rise of non-canonical ADP-ribosylation

Articles

N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Samuel Pazicky, Arne Alder, Haydyn Mertens, Dmitri Svergun, Tim Gilberger, Christian Löw

Biochem J (2022) 479 (3): 337–356.

DOI: https://doi.org/10.1042/BCJ20210829

Published: 04 February 2022

View article titled, N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Includes: Supplementary data

Articles

Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation

Rayner M. L. Queiroz, Siân C. Piper, Johanna S. Rees, Sam Strickson, Emmanuel Briend, Choon Pei Low, G. John Ferguson, Kathryn S. Lilley, Antony P. Jackson, Donna K. Finch

Biochem J (2022) 479 (3): 225–243.

DOI: https://doi.org/10.1042/BCJ20210313

Published: 04 February 2022

View article titled, Proteomic analysis in primary T cells reveals IL-7 alters T cell receptor thresholding via CYTIP/cytohesin/LFA-1 localisation and activation

Includes: Supplementary data

Articles

IKKα plays a major role in canonical NF-κB signalling in colorectal cells

In Collection

Cell death and survival

Jack A. Prescott, Kathryn Balmanno, Jennifer P. Mitchell, Hanneke Okkenhaug, Simon J. Cook

Biochem J (2022) 479 (3): 305–325.

DOI: https://doi.org/10.1042/BCJ20210783

Published: 04 February 2022

View article titled, IKKα plays a major role in canonical NF-κB signalling in colorectal cells

Includes: Supplementary data

Articles

Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly

Yashwanth Ashok, Carlos Vela-Rodríguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö

Biochem J (2022) 479 (3): 289–304.

DOI: https://doi.org/10.1042/BCJ20210722

Published: 04 February 2022

View article titled, Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly

Includes: Supplementary data

Articles

Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

Johanna Kliche, Ylva Ivarsson

Biochem J (2022) 479 (1): 1–22.

DOI: https://doi.org/10.1042/BCJ20200714

Published: 06 January 2022

View article titled, Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

Articles

An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells

Helen A. Brown, Charles A.C. Williams, Houjiang Zhou, Diana Rios-Szwed, Rosalia Fernandez-Alonso, Saria Mansoor, Liam McMulkin, Rachel Toth, Robert Gourlay, Julien Peltier, Nora Dieguez-Martinez, Matthias Trost, Jose M. Lizcano, Marios P. Stavridis, Greg M. Findlay

Biochem J (2021) 478 (23): 4119–4136.

DOI: https://doi.org/10.1042/BCJ20210646

Published: 06 December 2021

View article titled, An ERK5–KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells

Articles

NAD + -consuming enzymes in immune defense against viral infection

Jialin Shang, Michael R. Smith, Ananya Anmangandla, Hening Lin

Biochem J (2021) 478 (23): 4071–4092.

DOI: https://doi.org/10.1042/BCJ20210181

Published: 06 December 2021

View article titled, NAD + -consuming enzymes in immune defense against viral infection

Articles

The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins

Rajasree Kalagiri, Tony Hunter

Biochem J (2021) 478 (19): 3575–3596.

DOI: https://doi.org/10.1042/BCJ20210533

Published: 08 October 2021

View article titled, The many ways that nature has exploited the unusual structural and chemical properties of phosphohistidine for use in proteins

Includes: Supplementary data

Articles

Stepwise oxidations play key roles in the structural and functional regulations of DJ-1

In-Kang Song, Mi-Sun Kim, James E. Ferrell Jr., Dong-Hae Shin, Kong-Joo Lee

Biochem J (2021) 478 (19): 3505–3525.

DOI: https://doi.org/10.1042/BCJ20210245

Published: 06 October 2021

View article titled, Stepwise oxidations play key roles in the structural and functional regulations of DJ-1

Includes: Supplementary data

Articles

Impact of Type II LRRK2 inhibitors on signaling and mitophagy

Anna Tasegian, Francois Singh, Ian G. Ganley, Alastair D. Reith, Dario R. Alessi

Biochem J (2021) 478 (19): 3555–3573.

DOI: https://doi.org/10.1042/BCJ20210375

Published: 06 October 2021

View article titled, Impact of Type II LRRK2 inhibitors on signaling and mitophagy

Includes: Supplementary data

Articles

Hydrogen sulfide in ageing, longevity and disease

Stephen E. Wilkie, Gillian Borland, Roderick N. Carter, Nicholas M. Morton, Colin Selman

Biochem J (2021) 478 (19): 3485–3504.

DOI: https://doi.org/10.1042/BCJ20210517

Published: 06 October 2021

View article titled, Hydrogen sulfide in ageing, longevity and disease

Articles

The BRCA1/BARD1 ubiquitin ligase and its substrates

Samuel R. Witus, Mikaela D. Stewart, Rachel E. Klevit

Biochem J (2021) 478 (18): 3467–3483.

DOI: https://doi.org/10.1042/BCJ20200864

Published: 30 September 2021

View article titled, The BRCA1/BARD1 ubiquitin ligase and its substrates

Articles

Electron inventory of the iron-sulfur scaffold complex HypCD essential in [NiFe]-hydrogenase cofactor assembly

Sven T. Stripp, Jonathan Oltmanns, Christina S. Müller, David Ehrenberg, Ramona Schlesinger, Joachim Heberle, Lorenz Adrian, Volker Schünemann, Antonio J. Pierik, Basem Soboh

Biochem J (2021) 478 (17): 3281–3295.

DOI: https://doi.org/10.1042/BCJ20210224

Published: 07 September 2021

View article titled, Electron inventory of the iron-sulfur scaffold complex HypCD essential in [NiFe]-hydrogenase cofactor assembly

Includes: Supplementary data

Articles

PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus

Teddy Kamata, Chun-Song Yang, Bryce M. Paschal

Biochem J (2021) 478 (15): 2999–3014.

DOI: https://doi.org/10.1042/BCJ20210378

Published: 10 August 2021

View article titled, PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus

Articles

Per aspera ad chaos : a personal journey to the wonderland of intrinsic disorder

Vladimir N. Uversky

Biochem J (2021) 478 (15): 3015–3024.

DOI: https://doi.org/10.1042/BCJ20210146

Published: 10 August 2021

View article titled, Per aspera ad chaos : a personal journey to the wonderland of intrinsic disorder

Articles

Cancer stem cell phosphatases

Majid Momeny, Tiina Arsiola, Jukka Westermarck

Biochem J (2021) 478 (14): 2899–2920.

DOI: https://doi.org/10.1042/BCJ20210254

Published: 28 July 2021

View article titled, Cancer stem cell phosphatases

Articles

Reconstitution of human CMG helicase ubiquitylation by CUL2 LRR1 and multiple E2 enzymes

Thanh Thi Le, Johanna Ainsworth, Cristian Polo Rivera, Thomas Macartney, Karim P.M. Labib

Biochem J (2021) 478 (14): 2825–2842.

DOI: https://doi.org/10.1042/BCJ20210315

Published: 23 July 2021

View article titled, Reconstitution of human CMG helicase ubiquitylation by CUL2 LRR1 and multiple E2 enzymes

Includes: Supplementary data

Articles

Importance of tyrosine phosphorylation for transmembrane signaling in plants

Henning Mühlenbeck, Kyle W. Bender, Cyril Zipfel

Biochem J (2021) 478 (14): 2759–2774.

DOI: https://doi.org/10.1042/BCJ20210202

Published: 23 July 2021

View article titled, Importance of tyrosine phosphorylation for transmembrane signaling in plants

Articles

Mechanistic roles for altered O -GlcNAcylation in neurodegenerative disorders

Aaron T. Balana, Matthew R. Pratt

Biochem J (2021) 478 (14): 2733–2758.

DOI: https://doi.org/10.1042/BCJ20200609

Published: 23 July 2021

View article titled, Mechanistic roles for altered O -GlcNAcylation in neurodegenerative disorders

Articles

Inhibitory feedback control of NF-κB signalling in health and disease

Jack A. Prescott, Jennifer P. Mitchell, Simon J. Cook

Biochem J (2021) 478 (13): 2619–2664.

DOI: https://doi.org/10.1042/BCJ20210139

Published: 16 July 2021

View article titled, Inhibitory feedback control of NF-κB signalling in health and disease

Articles

CLN5 and CLN3 function as a complex to regulate endolysosome function

Seda Yasa, Etienne Sauvageau, Graziana Modica, Stephane Lefrancois

Biochem J (2021) 478 (12): 2339–2357.

DOI: https://doi.org/10.1042/BCJ20210171

Published: 23 June 2021

View article titled, CLN5 and CLN3 function as a complex to regulate endolysosome function

Includes: Supplementary data

Articles

Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7

Izabela Maluch, Justyna Grzymska, Scott J. Snipas, Guy S. Salvesen, Marcin Drag

Biochem J (2021) 478 (12): 2233–2245.

DOI: https://doi.org/10.1042/BCJ20210255

Published: 18 June 2021

View article titled, Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7

Includes: Supplementary data

Articles

Inhibition of selective autophagy by members of the herpesvirus ubiquitin-deconjugase family

Päivi Ylä-Anttila, Maria G. Masucci

Biochem J (2021) 478 (12): 2297–2308.

DOI: https://doi.org/10.1042/BCJ20210225

Published: 18 June 2021

View article titled, Inhibition of selective autophagy by members of the herpesvirus ubiquitin-deconjugase family

Articles

The parkinsonism-associated protein FBXO7 cooperates with the BAG6 complex in proteasome function and controls the subcellular localization of the complex

Quan Wang, Vanessa Crnković, Christian Preisinger, Judith Stegmüller

Biochem J (2021) 478 (12): 2179–2199.

DOI: https://doi.org/10.1042/BCJ20201000

Published: 18 June 2021

View article titled, The parkinsonism-associated protein FBXO7 cooperates with the BAG6 complex in proteasome function and controls the subcellular localization of the complex

Articles

Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase

Yi Liu, Sung-Mi Kim, YongQiang Wang, Shay Karkashon, Ariel Lewis-Ballester, Syun-Ru Yeh, Maria Almira Correia

Biochem J (2021) 478 (10): 1999–2017.

DOI: https://doi.org/10.1042/BCJ20210213

Published: 28 May 2021

View article titled, Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase

Includes: Supplementary data

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