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Articles

The role of phosphorylation in calmodulin-mediated gating of human AQP0

Stefan Kreida, Jennifer Virginia Roche, Julie Winkel Missel, Tamim Al-Jubair, Carl Johan Hagströmer, Veronika Wittenbecher, Sara Linse, Pontus Gourdon, Susanna Törnroth-Horsefield

Biochem J (2023) BCJ20230158.

https://doi.org/10.1042/BCJ20230158

Published: 30 November 2023

View article titled, The role of phosphorylation in calmodulin-mediated gating of human AQP0

Articles

Elucidating the interaction of C-terminal domain of Vaccinia-Related Kinase 2A (VRK2A) with B-cell lymphoma-extra Large (Bcl-xL) to decipher its anti-apoptotic role in cancer

Rashmi Puja, Shubhankar Dutta, Kakoli Bose

Biochem J (2023) 480 (22): 1871–1885.

https://doi.org/10.1042/BCJ20230349

Published: 28 November 2023

View article titled, Elucidating the interaction of C-terminal domain of Vaccinia-Related Kinase 2A (VRK2A) with B-cell lymphoma-extra Large (Bcl-xL) to decipher its anti-apoptotic role in cancer

Includes: Supplementary data

Articles

Targeting bacterial degradation machinery as an antibacterial strategy

Radoslav Petkov, Amy H. Camp, Rivka L. Isaacson, James H. Torpey

Biochem J (2023) 480 (21): 1719–1731.

https://doi.org/10.1042/BCJ20230191

Published: 02 November 2023

View article titled, Targeting bacterial degradation machinery as an antibacterial strategy

Articles

Fluorescent biosensors illuminate the spatial regulation of cell signaling across scales

Anne C. Lyons, Sohum Mehta, Jin Zhang

Biochem J (2023) 480 (20): 1693–1717.

https://doi.org/10.1042/BCJ20220223

Published: 30 October 2023

View article titled, Fluorescent biosensors illuminate the spatial regulation of cell signaling across scales

Articles

Mitophagy in yeast: known unknowns and unknown unknowns

Hagai Abeliovich

Biochem J (2023) 480 (20): 1639–1657.

https://doi.org/10.1042/BCJ20230279

Published: 18 October 2023

View article titled, Mitophagy in yeast: known unknowns and unknown unknowns

Articles

Comprehensive comparative assessment of the Arabidopsis thaliana MLO2–CALMODULIN2 interaction by various in vitro and in vivo protein–protein interaction assays

Kira von Bongartz, Björn Sabelleck, Anežka Baquero Forero, Hannah Kuhn, Franz Leissing, Ralph Panstruga

Biochem J (2023) 480 (20): 1615–1638.

https://doi.org/10.1042/BCJ20230255

Published: 13 October 2023

View article titled, Comprehensive comparative assessment of the Arabidopsis thaliana MLO2–CALMODULIN2 interaction by various in vitro and in vivo protein–protein interaction assays

Includes: Supplementary data

Articles

Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex

Takumi Hagiwara, Ryosuke Minami, Chizuru Ushio, Naoto Yokota, Hiroyuki Kawahara

Biochem J (2023) 480 (19): 1583–1598.

https://doi.org/10.1042/BCJ20230267

Published: 11 October 2023

View article titled, Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex

Includes: Supplementary data

Articles

The choreography of protein kinase PDK1 and its diverse substrate dance partners

In Collection

Cell signaling in the 21st century

Alejandro E. Leroux, Ricardo M. Biondi

Biochem J (2023) 480 (19): 1503–1532.

https://doi.org/10.1042/BCJ20220396

Published: 04 October 2023

View article titled, The choreography of protein kinase PDK1 and its diverse substrate dance partners

Articles

Lhs1 dependent ERAD is determined by transmembrane domain context

Maria Sukhoplyasova, Abigail M. Keith, Emma M. Perrault, Hannah E. Vorndran, Alexa S. Jordahl, Megan E. Yates, Ashutosh Pastor, Zachary Li, Michael L. Freaney, Riddhi A. Deshpande, David B. Adams, Christopher J. Guerriero, Shujie Shi, Thomas R. Kleyman, Ossama B. Kashlan, Jeffrey L. Brodsky, Teresa M. Buck

Biochem J (2023) 480 (18): 1459–1473.

https://doi.org/10.1042/BCJ20230075

Published: 21 September 2023

View article titled, Lhs1 dependent ERAD is determined by transmembrane domain context

Includes: Supplementary data

Articles

Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues

Kyler A. Weingartner, Thao Tran, Katherine W. Tripp, Jennifer M. Kavran

Biochem J (2023) 480 (15): 1165–1182.

https://doi.org/10.1042/BCJ20230067

Published: 27 July 2023

View article titled, Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues

Includes: Supplementary data

Articles

RhoGAP6 interacts with COPI to regulate protein transport

Lorna O'Donoghue, Shane P. Comer, Dishon W. Hiebner, Ingmar Schoen, Alex von Kriegsheim, Albert Smolenski

Biochem J (2023) 480 (14): 1109–1127.

https://doi.org/10.1042/BCJ20230013

Published: 19 July 2023

View article titled, RhoGAP6 interacts with COPI to regulate protein transport

Articles

Outer membrane translocation of pyocins via the copper regulated TonB-dependent transporter CrtA

Jiraphan Premsuriya, Khedidja Mosbahi, Iva Atanaskovic, Colin Kleanthous, Daniel Walker

Biochem J (2023) 480 (14): 1035–1049.

https://doi.org/10.1042/BCJ20220552

Published: 17 July 2023

View article titled, Outer membrane translocation of pyocins via the copper regulated TonB-dependent transporter CrtA

Includes: Supplementary data

Articles

Calcium signalling components underlying NPK homeostasis: potential avenues for exploration

In Collection

Plants and climate change: the role of plants in achieving net zero

Sonam Pahuja, Malathi Bheri, Diksha Bisht, Girdhar K. Pandey

Biochem J (2023) 480 (13): 1015–1034.

https://doi.org/10.1042/BCJ20230156

Published: 07 July 2023

View article titled, Calcium signalling components underlying NPK homeostasis: potential avenues for exploration

Articles

The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors

Simon Bressendorff, Swathi Kausika, Ida Marie Zobbe Sjøgaard, Emilie Duus Oksbjerg, Alec Michels, Christian Poulsen, Peter Brodersen

Biochem J (2023) 480 (13): 957–974.

https://doi.org/10.1042/BCJ20230025

Published: 06 July 2023

View article titled, The N-coil and the globular N-terminal domain of plant ARGONAUTE1 are interaction hubs for regulatory factors

Includes: Supplementary data

Articles

Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI

In Collection

Cell signaling in the 21st century

Mitchell H. Omar, Maryanne Kihiu, Dominic P. Byrne, Kyung-Soon Lee, Tyler M. Lakey, Erik Butcher, Patrick A. Eyers, John D. Scott

Biochem J (2023) 480 (12): 875–890.

https://doi.org/10.1042/BCJ20230183

Published: 22 June 2023

View article titled, Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI

Articles

Capturing the domain crosstalk in full length LRRK2 and LRRK2 RCKW

In Collection

Cell signaling in the 21st century

Eliza Störmer, Jui-Hung Weng, Jian Wu, Daniela Bertinetti, Pallavi Kaila Sharma, Wen Ma, Friedrich W. Herberg, Susan S. Taylor

Biochem J (2023) 480 (11): 815–833.

https://doi.org/10.1042/BCJ20230126

Published: 12 June 2023

View article titled, Capturing the domain crosstalk in full length LRRK2 and LRRK2 RCKW

Includes: Supplementary data

Articles

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

A. Jane Bardwell, Madhuri Paul, Kiku C. Yoneda, María D. Andrade-Ludeña, Oanh T. Nguyen, David A. Fruman, Lee Bardwell

Biochem J (2023) 480 (10): 729–750.

https://doi.org/10.1042/BCJ20220493

Published: 26 May 2023

View article titled, The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

Articles

Emerging functions of pseudoenzymes

In Collection

Cell signaling in the 21st century

Timea Goldberg, Anju Sreelatha

Biochem J (2023) 480 (10): 715–728.

https://doi.org/10.1042/BCJ20220373

Published: 19 May 2023

View article titled, Emerging functions of pseudoenzymes

Articles

Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine

Lillian F. Schmaltz, Myong-Chul Koag, Yi Kou, Louis Zhang, Seongmin Lee

Biochem J (2023) 480 (9): 573–585.

https://doi.org/10.1042/BCJ20220460

Published: 04 May 2023

View article titled, Genotoxic effects of the major alkylation damage N7-methylguanine and methyl formamidopyrimidine

Articles

Self-assembly of shell protein and native enzyme in a crowded environment leads to catalytically active phase condensates

Gaurav Kumar, Sharmistha Sinha

Biochem J (2023) 480 (8): 539–553.

https://doi.org/10.1042/BCJ20220551

Published: 26 April 2023

View article titled, Self-assembly of shell protein and native enzyme in a crowded environment leads to catalytically active phase condensates

Includes: Multimedia, Supplementary data

Articles

Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity

Linna Han, Jessica B. Lee, Elaine W. Indermaur, Albert J. Keung

Biochem J (2023) 480 (6): 421–432.

https://doi.org/10.1042/BCJ20220528

Published: 24 March 2023

View article titled, Chaetocin disrupts the SUV39H1–HP1 interaction independent of SUV39H1 methyltransferase activity

Includes: Supplementary data

Articles

Interaction of the periplasmic chaperone SurA with the inner membrane protein secretion (SEC) machinery

Lucy Troman, Sara Alvira, Bertram Daum, Vicki A. M. Gold, Ian Collinson

Biochem J (2023) 480 (4): 283–296.

https://doi.org/10.1042/BCJ20220480

Published: 27 February 2023

View article titled, Interaction of the periplasmic chaperone SurA with the inner membrane protein secretion (SEC) machinery

Includes: Supplementary data

Articles

Protein kinase C showcases allosteric control: activation of LRRK1

Hannah Tovell, Alexandra C. Newton

Biochem J (2023) 480 (3): 219–223.

https://doi.org/10.1042/BCJ20220507

Published: 10 February 2023

View article titled, Protein kinase C showcases allosteric control: activation of LRRK1

Articles

The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress

Manisha Banerjee, Namrata Waghamare, Prakash Kalwani, Deepak T. Hurali, Rachna Agarwal, Anand Ballal

Biochem J (2023) 480 (1): 87–104.

https://doi.org/10.1042/BCJ20220524

Published: 13 January 2023

View article titled, The atypical thioredoxin ‘Alr2205’, a newly identified partner of the typical 2-Cys-Peroxiredoxin, safeguards the cyanobacterium Anabaena from oxidative stress

Includes: Supplementary data

Articles

Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry

Karin Murakami, Ryo Tamura, Sanae Ikehara, Hayato Ota, Tomomi Ichimiya, Naoki Matsumoto, Hisahiro Matsubara, Shoko Nishihara, Yuzuru Ikehara, Kazuo Yamamoto

Biochem J (2023) 480 (1): 41–56.

https://doi.org/10.1042/BCJ20220339

Published: 06 January 2023

View article titled, Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry

Includes: Supplementary data

Articles

Dynamic regulation of RAS and RAS signaling

In Collection

Cell signaling in the 21st century

Walter Kolch, Dénes Berta, Edina Rosta

Biochem J (2023) 480 (1): 1–23.

https://doi.org/10.1042/BCJ20220234

Published: 06 January 2023

View article titled, Dynamic regulation of RAS and RAS signaling

Articles

Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity

Foteini Bartzoka, Monica Gonzalez-Magaldi, Patrick O. Byrne, Nicole I. Callery, Kalina Hristova, Daniel J. Leahy

Biochem J (2022) 479 (24): 2465–2475.

https://doi.org/10.1042/BCJ20220472

Published: 19 December 2022

View article titled, Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity

Includes: Supplementary data

Articles

PI(4,5)P 2 : signaling the plasma membrane

Rachel C. Wills, Gerald R. V. Hammond

Biochem J (2022) 479 (21): 2311–2325.

https://doi.org/10.1042/BCJ20220445

Published: 11 November 2022

View article titled, PI(4,5)P 2 : signaling the plasma membrane

Articles

Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase

Lillian F. Schmaltz, Julia E. Ceniceros, Seongmin Lee

Biochem J (2022) 479 (21): 2297–2309.

https://doi.org/10.1042/BCJ20220438

Published: 04 November 2022

View article titled, Structure of the major oxidative damage 7,8-dihydro-8-oxoguanine presented into a catalytically competent DNA glycosylase

Articles

Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5

Mizuho Kajikawa, Mizuki Hata, Maho Ishimura, Nanae Imaizumi, Minako Kimura, Kei Miyano, Toyoyuki Ose, Daisuke Asai, Satoshi Ishido, Taisei Kanamoto

Biochem J (2022) 479 (20): 2261–2278.

https://doi.org/10.1042/BCJ20220288

Published: 28 October 2022

View article titled, Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5

Includes: Supplementary data

Articles

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Tom Snelling, Natalia Shpiro, Robert Gourlay, Frederic Lamoliatte, Philip Cohen

Biochem J (2022) 479 (20): 2195–2216.

https://doi.org/10.1042/BCJ20220401

Published: 21 October 2022

View article titled, Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

Includes: Supplementary data

Articles

Effect of α-helical domain of Gi/o α subunit on GDP/GTP turnover

Hee Ryung Kim, Donghoon Ahn, Jae Beom Jo, Ka Young Chung

Biochem J (2022) 479 (17): 1843–1855.

https://doi.org/10.1042/BCJ20220163

Published: 12 September 2022

View article titled, Effect of α-helical domain of Gi/o α subunit on GDP/GTP turnover

Includes: Supplementary data

Articles

Structural and functional characterisation of a stable, broad-specificity multimeric sialidase from the oral pathogen Tannerella forsythia

Marianne J. Satur, Paulina A. Urbanowicz, Daniel I. R. Spencer, John Rafferty, Graham P. Stafford

Biochem J (2022) 479 (17): 1785–1806.

https://doi.org/10.1042/BCJ20220244

Published: 06 September 2022

View article titled, Structural and functional characterisation of a stable, broad-specificity multimeric sialidase from the oral pathogen Tannerella forsythia

Includes: Supplementary data

Articles

The function of BK channels extracted and purified within SMALPs

Jaimin H. Patel, Naomi L. Pollock, Jacqueline Maher, Alice J. Rothnie, Marcus C. Allen

Biochem J (2022) 479 (15): 1609–1619.

https://doi.org/10.1042/BCJ20210628

Published: 05 August 2022

View article titled, The function of BK channels extracted and purified within SMALPs

Includes: Supplementary data

Articles

Binding of the Mycobacterium tuberculosis EccCb1 ATPase double hexameric ring to the EsxAB virulence factor is enhanced by ATP

Arkita Bandyopadhyay, Ramesh Kumar, Jyotsna Singh, Ajay K. Saxena

Biochem J (2022) 479 (14): 1559–1579.

https://doi.org/10.1042/BCJ20210430

Published: 21 July 2022

View article titled, Binding of the Mycobacterium tuberculosis EccCb1 ATPase double hexameric ring to the EsxAB virulence factor is enhanced by ATP

Includes: Supplementary data

Articles

Identification of ELK1 interacting peptide segments in the androgen receptor

Claire Soave, Charles Ducker, Seongho Kim, Thomas Strahl, Rayna Rosati, Yanfang Huang, Peter E. Shaw, Manohar Ratnam

Biochem J (2022) 479 (14): 1519–1531.

https://doi.org/10.1042/BCJ20220297

Published: 21 July 2022

View article titled, Identification of ELK1 interacting peptide segments in the androgen receptor

Includes: Supplementary data

Articles

Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes

Emily L. Button, Joseph J. Rossi, Daniel P. McDougal, John B. Bruning, Daniel J. Peet, David C. Bersten, Jill A. Rosenfeld, Murray L. Whitelaw

Biochem J (2022) 479 (13): 1441–1454.

https://doi.org/10.1042/BCJ20220209

Published: 13 July 2022

View article titled, Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes

Includes: Supplementary data

Articles

Binding partners regulate unfolding of myosin VI to activate the molecular motor

Ália dos Santos, Natalia Fili, Yukti Hari-Gupta, Rosemarie E. Gough, Lin Wang, Marisa Martin-Fernandez, Jesse Aaron, Eric Wait, Teng-Leong Chew, Christopher P. Toseland

Biochem J (2022) 479 (13): 1409–1428.

https://doi.org/10.1042/BCJ20220025

Published: 04 July 2022

View article titled, Binding partners regulate unfolding of myosin VI to activate the molecular motor

Includes: Supplementary data

Articles

CORM-3 induces DNA damage through Ru(II) binding to DNA

Rhiannon F. Lyon, Hannah M. Southam, Clare R. Trevitt, Chunyan Liao, Sherif F. El-Khamisy, Robert K. Poole, Mike P. Williamson

Biochem J (2022) 479 (13): 1429–1439.

https://doi.org/10.1042/BCJ20220254

Published: 04 July 2022

View article titled, CORM-3 induces DNA damage through Ru(II) binding to DNA

Articles

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors

Justine Mailliot, Mirella Vivoli-Vega, Christiane Schaffitzel

Biochem J (2022) 479 (9): 973–993.

https://doi.org/10.1042/BCJ20210556

Published: 12 May 2022

View article titled, No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors

Articles

LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin

Yuan Zhang, Min Zhu, Chunlei Zheng, Wei Wei, Brian T. Emmer, Bin Zhang

Biochem J (2022) 479 (7): 839–855.

https://doi.org/10.1042/BCJ20220055

Published: 11 April 2022

View article titled, LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin

Includes: Supplementary data

Articles

Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

Karen M. Dunkerley, Anne C. Rintala-Dempsey, Giulia Salzano, Roya Tadayon, Dania Hadi, Kathryn R. Barber, Helen Walden, Gary S. Shaw

Biochem J (2022) 479 (6): 751–766.

https://doi.org/10.1042/BCJ20210741

Published: 28 March 2022

View article titled, Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

Includes: Supplementary data

Articles

APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Yingying Liu, Xiaochuan Ma, Hui Yang, Xun Li, Yingli Ma, Brandon Ason, Suling Liu, Liaoyuan A. Hu

Biochem J (2022) 479 (3): 385–399.

https://doi.org/10.1042/BCJ20210813

Published: 11 February 2022

View article titled, APLNR Regulates IFN-γ signaling via β-arrestin 1 mediated JAK-STAT1 pathway in melanoma cells

Includes: Supplementary data

Articles

TAT–RHIM: a more complex issue than expected

In Collection

Cell death and survival

Benedikt Kolbrink, Theresa Riebeling, Nikolas K. Teiwes, Claudia Steinem, Hubert Kalbacher, Ulrich Kunzendorf, Stefan Krautwald

Biochem J (2022) 479 (3): 259–272.

https://doi.org/10.1042/BCJ20210677

Published: 04 February 2022

View article titled, TAT–RHIM: a more complex issue than expected

Articles

Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly

Yashwanth Ashok, Carlos Vela-Rodríguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö

Biochem J (2022) 479 (3): 289–304.

https://doi.org/10.1042/BCJ20210722

Published: 04 February 2022

View article titled, Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly

Includes: Supplementary data

Articles

SNARE proteins: zip codes in vesicle targeting?

Seiichi Koike, Reinhard Jahn

Biochem J (2022) 479 (3): 273–288.

https://doi.org/10.1042/BCJ20210719

Published: 04 February 2022

View article titled, SNARE proteins: zip codes in vesicle targeting?

Articles

Proteomic analysis identifies ZMYM2 as endogenous binding partner of TBX18 protein in 293 and A549 cells

Timo H.-W. Lüdtke, Marc-Jens Kleppa, Reginaldo Rivera-Reyes, Fairouz Qasrawi, Dervla M. Connaughton, Shirlee Shril, Friedhelm Hildebrandt, Andreas Kispert

Biochem J (2022) 479 (1): 91–109.

https://doi.org/10.1042/BCJ20210642

Published: 14 January 2022

View article titled, Proteomic analysis identifies ZMYM2 as endogenous binding partner of TBX18 protein in 293 and A549 cells

Includes: Supplementary data

Articles

The optimal pH of AID is skewed from that of its catalytic pocket by DNA-binding residues and surface charge

Atefeh Ghorbani, Justin J. King, Mani Larijani

Biochem J (2022) 479 (1): 39–55.

https://doi.org/10.1042/BCJ20210529

Published: 06 January 2022

View article titled, The optimal pH of AID is skewed from that of its catalytic pocket by DNA-binding residues and surface charge

Includes: Supplementary data

Articles

Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

Johanna Kliche, Ylva Ivarsson

Biochem J (2022) 479 (1): 1–22.

https://doi.org/10.1042/BCJ20200714

Published: 06 January 2022

View article titled, Orchestrating serine/threonine phosphorylation and elucidating downstream effects by short linear motifs

Articles

Signalling dynamics in embryonic development

Katharina F. Sonnen, Claudia Y. Janda

Biochem J (2021) 478 (23): 4045–4070.

https://doi.org/10.1042/BCJ20210043

Published: 06 December 2021

View article titled, Signalling dynamics in embryonic development

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