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Articles

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

In Collection

Catia L. Pierotti, Annette V. Jacobsen, Christoph Grohmann, Ruby K. Dempsey, Nima Etemadi, Joanne M. Hildebrand, Cheree Fitzgibbon, Samuel N. Young, Katherine A. Davies, Wilhelmus J. A. Kersten, John Silke, Kym N. Lowes, Hélène Jousset Sabroux, David C. S. Huang, Mark F. van Delft, James M. Murphy, Guillaume Lessene

Biochem J (2023) 480 (9): 665–684.

DOI: https://doi.org/10.1042/BCJ20230035

Published: 12 May 2023

View article titled, The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

Articles

Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition

In Collection

Plants and climate change: the role of plants in achieving net zero

Wanda M. Waterworth, Christopher E. West

Biochem J (2023) 480 (7): 461–470.

DOI: https://doi.org/10.1042/BCJ20230006

Published: 04 April 2023

View article titled, Genome damage accumulated in seed ageing leads to plant genome instability and growth inhibition

Articles

BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

In Collection

Cell death and survival

Gabriela Brumatti, Deeksha Kaloni, Fabíola Attié Castro, Gustavo P. Amarante-Mendes

Biochem J (2023) 480 (2): 161–176.

DOI: https://doi.org/10.1042/BCJ20210608

Published: 31 January 2023

View article titled, BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

Articles

Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner

Enoli De Silva, Dana V. Devine, Eric Jan, Calvin D. Roskelley, Hugh Kim

Biochem J (2022) 479 (22): 2351–2364.

DOI: https://doi.org/10.1042/BCJ20220177

Published: 23 November 2022

View article titled, Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner

Includes: Supplementary data

Articles

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

In Collection

Awards

D. Grahame Hardie

Biochem J (2022) 479 (22): 2327–2343.

DOI: https://doi.org/10.1042/BCJ20220255

Published: 16 November 2022

View article titled, AMP-activated protein kinase — a journey from 1 to 100 downstream targets

Articles

Mechanisms of TNF-independent RIPK3-mediated cell death

Bart Tummers, Douglas R. Green

Biochem J (2022) 479 (19): 2049–2062.

DOI: https://doi.org/10.1042/BCJ20210724

Published: 14 October 2022

View article titled, Mechanisms of TNF-independent RIPK3-mediated cell death

Articles

PON2 mediates mitochondrial dysfunction in tracheal epithelial cells in response to a quorum sensing molecule N-(-3-oxododecanoyl)-l-homoserine lactone

Aaron G. Whitt, Shuhan Meng, Jiu-Zhen Jin, Lindsey R. Conroy, Lindsey A. McNally, Joseph A. Burlison, Bradford G. Hill, Brian F. Clem, Carl White, Chi Li

Biochem J (2022) 479 (19): 2013–2034.

DOI: https://doi.org/10.1042/BCJ20220100

Published: 07 October 2022

View article titled, PON2 mediates mitochondrial dysfunction in tracheal epithelial cells in response to a quorum sensing molecule N-(-3-oxododecanoyl)-l-homoserine lactone

Includes: Supplementary data

Articles

Cell death in skin function, inflammation, and disease

In Collection

Cell death and survival

Holly Anderton, Suhaib Alqudah

Biochem J (2022) 479 (15): 1621–1651.

DOI: https://doi.org/10.1042/BCJ20210606

Published: 05 August 2022

View article titled, Cell death in skin function, inflammation, and disease

Articles

The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?

In Collection

Cell death and survival

Kamil Seyrek, Fabian Wohlfromm, Johannes Espe, Inna N. Lavrik

Biochem J (2022) 479 (14): 1581–1608.

DOI: https://doi.org/10.1042/BCJ20210676

Published: 29 July 2022

View article titled, The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?

Articles

Distinct interactors define the p63 transcriptional signature in epithelial development or cancer

In Collection

Cell death and survival

Rosalba Pecorari, Francesca Bernassola, Gerry Melino, Eleonora Candi

Biochem J (2022) 479 (12): 1375–1392.

DOI: https://doi.org/10.1042/BCJ20210737

Published: 24 June 2022

View article titled, Distinct interactors define the p63 transcriptional signature in epithelial development or cancer

Articles

Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure

Hossein Allahmoradi, S. Mohsen Asghari, Atieh Ahmadi, Elham Assareh, Mahboobeh Nazari

Biochem J (2022) 479 (12): 1285–1302.

DOI: https://doi.org/10.1042/BCJ20210830

Published: 21 June 2022

View article titled, Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure

Includes: Supplementary data

Articles

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Emily C. Matchett, Elise C. Ambrose, Jacki Kornbluth

Biochem J (2022) 479 (11): 1149–1164.

DOI: https://doi.org/10.1042/BCJ20210770

Published: 08 June 2022

View article titled, Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Articles

Deubiquitinases in cell death and inflammation

In Collection

Cell death and survival

Kim Newton, Alexander D. Gitlin

Biochem J (2022) 479 (10): 1103–1119.

DOI: https://doi.org/10.1042/BCJ20210735

Published: 24 May 2022

View article titled, Deubiquitinases in cell death and inflammation

Articles

No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death

In Collection

Cell death and survival

Ashley Weir, James E. Vince

Biochem J (2022) 479 (10): 1083–1102.

DOI: https://doi.org/10.1042/BCJ20210711

Published: 24 May 2022

View article titled, No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death

Articles

Alveolar cells in the mammary gland: lineage commitment and cell death

In Collection

Cell death and survival

Christine J. Watson

Biochem J (2022) 479 (9): 995–1006.

DOI: https://doi.org/10.1042/BCJ20210734

Published: 12 May 2022

View article titled, Alveolar cells in the mammary gland: lineage commitment and cell death

Articles

RIP1 post-translational modifications

In Collection

Cell death and survival

Eugene Varfolomeev, Domagoj Vucic

Biochem J (2022) 479 (9): 929–951.

DOI: https://doi.org/10.1042/BCJ20210725

Published: 06 May 2022

View article titled, RIP1 post-translational modifications

Articles

Ferroptosis in plants: regulation of lipid peroxidation and redox status

In Collection

Cell death and survival

Ayelén Mariana Distéfano, Gabriel Alejandro López, Victoria Bauer, Eduardo Zabaleta, Gabriela Carolina Pagnussat

Biochem J (2022) 479 (7): 857–866.

DOI: https://doi.org/10.1042/BCJ20210682

Published: 19 April 2022

View article titled, Ferroptosis in plants: regulation of lipid peroxidation and redox status

Articles

Activation and manipulation of inflammasomes and pyroptosis during bacterial infections

In Collection

Cell death and survival

Elliott M. Bernard, Petr Broz

Biochem J (2022) 479 (7): 867–882.

DOI: https://doi.org/10.1042/BCJ20220051

Published: 19 April 2022

View article titled, Activation and manipulation of inflammasomes and pyroptosis during bacterial infections

Articles

Regulation of the release of damage-associated molecular patterns from necroptotic cells

In Collection

Cell death and survival

Hiroyasu Nakano, Shin Murai, Kenta Moriwaki

Biochem J (2022) 479 (5): 677–685.

DOI: https://doi.org/10.1042/BCJ20210604

Published: 16 March 2022

View article titled, Regulation of the release of damage-associated molecular patterns from necroptotic cells

Includes: Supplementary data

Articles

Programmed cell death: the pathways to severe COVID-19?

In Collection

Cell death and survival , Coronavirus

Stefanie M. Bader, James P. Cooney, Marc Pellegrini, Marcel Doerflinger

Biochem J (2022) 479 (5): 609–628.

DOI: https://doi.org/10.1042/BCJ20210602

Published: 04 March 2022

View article titled, Programmed cell death: the pathways to severe COVID-19?

Articles

The concept of intrinsic versus extrinsic apoptosis

In Collection

Cell death and survival

Laura Lossi

Biochem J (2022) 479 (3): 357–384.

DOI: https://doi.org/10.1042/BCJ20210854

Published: 11 February 2022

View article titled, The concept of intrinsic versus extrinsic apoptosis

Articles

TAT–RHIM: a more complex issue than expected

In Collection

Cell death and survival

Benedikt Kolbrink, Theresa Riebeling, Nikolas K. Teiwes, Claudia Steinem, Hubert Kalbacher, Ulrich Kunzendorf, Stefan Krautwald

Biochem J (2022) 479 (3): 259–272.

DOI: https://doi.org/10.1042/BCJ20210677

Published: 04 February 2022

View article titled, TAT–RHIM: a more complex issue than expected

Articles

IKKα plays a major role in canonical NF-κB signalling in colorectal cells

In Collection

Cell death and survival

Jack A. Prescott, Kathryn Balmanno, Jennifer P. Mitchell, Hanneke Okkenhaug, Simon J. Cook

Biochem J (2022) 479 (3): 305–325.

DOI: https://doi.org/10.1042/BCJ20210783

Published: 04 February 2022

View article titled, IKKα plays a major role in canonical NF-κB signalling in colorectal cells

Includes: Supplementary data

Articles

The complex interplay between autophagy and cell death pathways

In Collection

Cell death and survival

Christina Ploumi, Margarita-Elena Papandreou, Nektarios Tavernarakis

Biochem J (2022) 479 (1): 75–90.

DOI: https://doi.org/10.1042/BCJ20210450

Published: 14 January 2022

View article titled, The complex interplay between autophagy and cell death pathways

Articles

The unfolding role of ceramide in coordinating retinoid-based cancer therapy

Botheina Ghandour, Ghassan Dbaibo, Nadine Darwiche

Biochem J (2021) 478 (19): 3621–3642.

DOI: https://doi.org/10.1042/BCJ20210368

Published: 14 October 2021

View article titled, The unfolding role of ceramide in coordinating retinoid-based cancer therapy

Articles

Kinases leave their mark on caspase substrates

Amy M. Weeks

Biochem J (2021) 478 (17): 3179–3184.

DOI: https://doi.org/10.1042/BCJ20210399

Published: 07 September 2021

View article titled, Kinases leave their mark on caspase substrates

Articles

Inhibitory feedback control of NF-κB signalling in health and disease

Jack A. Prescott, Jennifer P. Mitchell, Simon J. Cook

Biochem J (2021) 478 (13): 2619–2664.

DOI: https://doi.org/10.1042/BCJ20210139

Published: 16 July 2021

View article titled, Inhibitory feedback control of NF-κB signalling in health and disease

Articles

Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells

Roman V. Lenchine, Sushma R. Rao, Xuemin Wang, Danielle Meiwen Fang, Christopher G. Proud

Biochem J (2021) 478 (8): 1547–1569.

DOI: https://doi.org/10.1042/BCJ20210126

Published: 21 April 2021

View article titled, Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells

Includes: Supplementary data

Articles

Lupeol-induced nitric oxide elicits apoptosis-like death within Escherichia coli in a DNA fragmentation-independent manner

Heesu Kim, Dong Gun Lee

Biochem J (2021) 478 (4): 855–869.

DOI: https://doi.org/10.1042/BCJ20200925

Published: 24 February 2021

View article titled, Lupeol-induced nitric oxide elicits apoptosis-like death within Escherichia coli in a DNA fragmentation-independent manner

Articles

Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity

Matthias Fellner, Rinky Parakra, Kirstin O. McDonald, Itamar Kass, Guy N.L. Jameson, Sigurd M. Wilbanks, Elizabeth C. Ledgerwood

Biochem J (2021) 478 (3): 669–684.

DOI: https://doi.org/10.1042/BCJ20200793

Published: 12 February 2021

View article titled, Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity

Includes: Supplementary data

Articles

Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells

Nikita Mundhara, Abhijit Majumder, Dulal Panda

Biochem J (2021) 478 (1): 179–196.

DOI: https://doi.org/10.1042/BCJ20200705

Published: 13 January 2021

View article titled, Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells

Includes: Supplementary data

Articles

Crystal structures of ORFV125 provide insight into orf virus-mediated inhibition of apoptosis

Chathura D. Suraweera, Mark G. Hinds, Marc Kvansakul

Biochem J (2020) 477 (23): 4527–4541.

DOI: https://doi.org/10.1042/BCJ20200776

Published: 03 December 2020

View article titled, Crystal structures of ORFV125 provide insight into orf virus-mediated inhibition of apoptosis

Includes: Supplementary data

Articles

Chemically based transmissible ER stress protocols are unsuitable to study cell-to-cell UPR transmission

Yohan Bignon, Virginie Poindessous, Luca Rampoldi, Violette Haldys, Nicolas Pallet

Biochem J (2020) 477 (20): 4037–4051.

DOI: https://doi.org/10.1042/BCJ20200699

Published: 29 October 2020

View article titled, Chemically based transmissible ER stress protocols are unsuitable to study cell-to-cell UPR transmission

Includes: Supplementary data

Articles

Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells

Zhou Zhou, Xiuzhen Li, Yisong Qian, Cynthia Liu, Xiaotian Huang, Mingui Fu

Biochem J (2020) 477 (20): 3923–3934.

DOI: https://doi.org/10.1042/BCJ20200351

Published: 23 October 2020

View article titled, Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells

Articles

The structural basis of Bcl-2 mediated cell death regulation in hydra

Suresh Banjara, Jaison D Sa, Mark G. Hinds, Marc Kvansakul

Biochem J (2020) 477 (17): 3287–3297.

DOI: https://doi.org/10.1042/BCJ20200556

Published: 10 September 2020

View article titled, The structural basis of Bcl-2 mediated cell death regulation in hydra

Articles

ALG2 Influences T cell apoptosis by regulating FASLG intracellular transportation

Wangsheng Ji, Yang Xin, Lianfei Zhang, Xinqi Liu

Biochem J (2020) 477 (16): 3105–3121.

DOI: https://doi.org/10.1042/BCJ20200028

Published: 28 August 2020

View article titled, ALG2 Influences T cell apoptosis by regulating FASLG intracellular transportation

Articles

Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes

Yujing Zhang, Huanfeng Bian, Yu Ma, Yuanyuan Xiao, Fang Xiao

Biochem J (2020) 477 (14): 2607–2619.

DOI: https://doi.org/10.1042/BCJ20200262

Published: 24 July 2020

View article titled, Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes

Articles

Synthesis and high antiproliferative activity of dehydroabietylamine pyridine derivatives in vitro and in vivo

Fengyi Zhao, Wen Lu, Yuanyuan Xu, Li Xu, Jingjing Zhang, Xu Sun, Shilong Yang, Mengyi Zhou, Fan Su, Feng Lin, Fuliang Cao

Biochem J (2020) 477 (12): 2383–2399.

DOI: https://doi.org/10.1042/BCJ20200337

Published: 26 June 2020

View article titled, Synthesis and high antiproliferative activity of dehydroabietylamine pyridine derivatives in vitro and in vivo

Includes: Supplementary data

Articles

A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacaspase-2

Vandana, Sudha Shankar, Kona Madhavinadha Prasad, Mohammad Kashif, Inderjeet Kalia, Rajkishor Rai, Agam P. Singh, Kailash C. Pandey

Biochem J (2020) 477 (7): 1323–1344.

DOI: https://doi.org/10.1042/BCJ20200050

Published: 17 April 2020

View article titled, A nonpeptidyl molecule modulates apoptosis-like cell death by inhibiting P. falciparum metacaspase-2

Includes: Supplementary data

Articles

Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease

Upasana Ganguly, Anindita Banerjee, Sankha Shubhra Chakrabarti, Upinder Kaur, Oishimaya Sen, Roberto Cappai, Sasanka Chakrabarti

Biochem J (2020) 477 (6): 1109–1122.

DOI: https://doi.org/10.1042/BCJ20190676

Published: 23 March 2020

View article titled, Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease

Includes: Supplementary data

Articles

A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells

Logan Slade, Dipsikha Biswas, Francis Ihionu, Yassine El Hiani, Petra C. Kienesberger, Thomas Pulinilkunnil

Biochem J (2020) 477 (1): 137–160.

DOI: https://doi.org/10.1042/BCJ20190596

Published: 10 January 2020

View article titled, A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells

Includes: Supplementary data

Articles

Astroglial contribution to tau-dependent neurodegeneration

Marta Sidoryk-Węgrzynowicz, Lidia Strużyńska

Biochem J (2019) 476 (22): 3493–3504.

DOI: https://doi.org/10.1042/BCJ20190506

Published: 27 November 2019

View article titled, Astroglial contribution to tau-dependent neurodegeneration

Articles

Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines

Iru Paudel, Sean M. Hernandez, Gilda M. Portalatin, Tara P. Chambers, Jeremy W. Chambers

Biochem J (2018) 475 (21): 3471–3492.

DOI: https://doi.org/10.1042/BCJ20180603

Published: 15 November 2018

View article titled, Sab concentrations indicate chemotherapeutic susceptibility in ovarian cancer cell lines

Includes: Supplementary data

Articles

The cloak, dagger, and shield: proteases in plant–pathogen interactions

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Shuguo Hou, Pierce Jamieson, Ping He

Biochem J (2018) 475 (15): 2491–2509.

DOI: https://doi.org/10.1042/BCJ20170781

Published: 16 August 2018

View article titled, The cloak, dagger, and shield: proteases in plant–pathogen interactions

Articles

CGA-N12, a peptide derived from chromogranin A, promotes apoptosis of Candida tropicalis by attenuating mitochondrial functions

Ruifang Li, Ruiling Zhang, Yanhui Yang, Xueqin Wang, Yanjie Yi, Pei Fan, Zhengwei Liu, Chen Chen, Junpeng Chang

Biochem J (2018) 475 (7): 1385–1396.

DOI: https://doi.org/10.1042/BCJ20170894

Published: 16 April 2018

View article titled, CGA-N12, a peptide derived from chromogranin A, promotes apoptosis of Candida tropicalis by attenuating mitochondrial functions

Articles

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

In Collection

Editors' pick of review article highlights published in the Biochemical Journal in 2018 & 2019

Hiroyuki Nakayama, Kinya Otsu

Biochem J (2018) 475 (5): 839–852.

DOI: https://doi.org/10.1042/BCJ20170714

Published: 06 March 2018

View article titled, Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

Articles

GPR4 knockout improves renal ischemia–reperfusion injury and inhibits apoptosis via suppressing the expression of CHOP

Biao Dong, Xiaolu Zhang, Yafeng Fan, Songqiang Cao, Xuepei Zhang

Biochem J (2017) 474 (24): 4065–4074.

DOI: https://doi.org/10.1042/BCJ20170676

Published: 01 December 2017

View article titled, GPR4 knockout improves renal ischemia–reperfusion injury and inhibits apoptosis via suppressing the expression of CHOP

Articles

Recombinant human islet amyloid polypeptide forms shorter fibrils and mediates β-cell apoptosis via generation of oxidative stress

Richa Dubey, Pooja Minj, Nikita Malik, Devika M. Sardesai, Shruti H. Kulkarni, Jhankar D. Acharya, Neel Sarovar Bhavesh, Shilpy Sharma, Ashutosh Kumar

Biochem J (2017) 474 (23): 3915–3934.

DOI: https://doi.org/10.1042/BCJ20170323

Published: 16 November 2017

View article titled, Recombinant human islet amyloid polypeptide forms shorter fibrils and mediates β-cell apoptosis via generation of oxidative stress

Includes: Supplementary data

Articles

Therapeutics targeting Bcl-2 in hematological malignancies

Astrid Ruefli-Brasse, John C. Reed

Biochem J (2017) 474 (21): 3643–3657.

DOI: https://doi.org/10.1042/BCJ20170080

Published: 23 October 2017

View article titled, Therapeutics targeting Bcl-2 in hematological malignancies

Articles

Glycerol-3-phosphate acyltransferase 2 is essential for normal spermatogenesis

Maria B. Garcia-Fabiani, Mauro A. Montanaro, Pablo Stringa, Ezequiel Lacunza, Elizabeth R. Cattaneo, Marianela Santana, Magali Pellon-Maison, Maria R. Gonzalez-Baro

Biochem J (2017) 474 (18): 3093–3107.

DOI: https://doi.org/10.1042/BCJ20161018

Published: 31 August 2017

View article titled, Glycerol-3-phosphate acyltransferase 2 is essential for normal spermatogenesis

Includes: Supplementary data

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