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Articles

How many kinases are druggable? A review of our current understanding

Brian Anderson, Peter Rosston, Han Wee Ong, Mohammad Anwar Hossain, Zachary W. Davis-Gilbert, David H. Drewry
Journal: Biochemical Journal
Biochem J (2023) 480 (16): 1331–1363.
https://doi.org/10.1042/BCJ20220217
Published: 29 August 2023
View article titled, How many kinases are druggable? A review of our current understanding
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Includes: Supplementary data
Articles

Development of an OTUD1 ubiquitin variant inhibitor

Qi Liu, Evan Mallette, Hui Zheng, Wei Zhang
Journal: Biochemical Journal
Biochem J (2023) 480 (16): 1317–1330.
https://doi.org/10.1042/BCJ20230119
Published: 25 August 2023
View article titled, Development of an OTUD1 ubiquitin variant inhibitor
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Includes: Supplementary data
Articles

SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer

Brooke D. Paradise, Vladimir G. Gainullin, Luciana L. Almada, Ashley N. Sigafoos, Sandhya Sen, Renzo E. Vera, Glancis Luzeena Raja Arul, Murat Toruner, David R. Pease, Alina L. Gonzalez, Fatima M. Mentucci, Daniel H. Grasso, Martin E. Fernandez-Zapico
Journal: Biochemical Journal
Biochem J (2023) 480 (15): 1199–1216.
https://doi.org/10.1042/BCJ20220439
Published: 02 August 2023
View article titled, SUFU promotes GLI activity in a Hedgehog-independent manner in pancreatic cancer
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Articles

Computational design of Matrix Metalloproteinase-9 (MMP-9) resistant to auto-cleavage

Alessandro Bonadio, Solomon Oguche, Tali Lavy, Oded Kleifeld, Julia Shifman
Journal: Biochemical Journal
Biochem J (2023) 480 (14): 1097–1107.
https://doi.org/10.1042/BCJ20230139
Published: 17 July 2023
View article titled, Computational design of Matrix Metalloproteinase-9 (MMP-9) resistant to auto-cleavage
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Includes: Supplementary data
Articles

The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase

A. Jane Bardwell, Madhuri Paul, Kiku C. Yoneda, María D. Andrade-Ludeña, Oanh T. Nguyen, David A. Fruman, Lee Bardwell
Journal: Biochemical Journal
Biochem J (2023) 480 (10): 729–750.
https://doi.org/10.1042/BCJ20220493
Published: 26 May 2023
View article titled, The WW domain of IQGAP1 binds directly to the p110α catalytic subunit of PI 3-kinase
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Articles

LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells

Haifeng Zhang, Shiyu Cui, Zhenghui Jing, Guodan Fu, Rong Liu, Wenbao Zhao, Liting Xu, Lei Yu, Yuhui Bai, Changsheng Lv, Min Wu, Yuan Wei, Liangming Li, Shuang Peng
Journal: Biochemical Journal
Biochem J (2023) 480 (9): 701–713.
https://doi.org/10.1042/BCJ20220614
Published: 17 May 2023
View article titled, LRRC8A is responsible for exosome biogenesis and volume regulation in colon cancer cells
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Includes: Supplementary data
Articles

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

In Collection
Cell signaling in the 21st century
Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook
Journal: Biochemical Journal
Biochem J (2023) 480 (9): 587–605.
https://doi.org/10.1042/BCJ20220598
Published: 04 May 2023
View article titled, ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1
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Includes: Supplementary data
Articles

Principles of phosphoproteomics and applications in cancer research

In Collection
Cell signaling in the 21st century
Luke Higgins, Henry Gerdes, Pedro R. Cutillas
Journal: Biochemical Journal
Biochem J (2023) 480 (6): 403–420.
https://doi.org/10.1042/BCJ20220220
Published: 24 March 2023
View article titled, Principles of phosphoproteomics and applications in cancer research
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Articles

GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration

Renzo E. Vera, María J. Lamberti, Luciana L. Almada, Ezequiel J. Tolosa, Anne M. Vrabel, Ashley N. Sigafoos, Merih D. Toruner, Luis F. Flores, Viviana A. Rivarola, Natalia B. Rumie Vittar, Martín E. Fernández-Zapico
Journal: Biochemical Journal
Biochem J (2023) 480 (3): 225–241.
https://doi.org/10.1042/BCJ20220521
Published: 14 February 2023
View article titled, GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration
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Includes: Supplementary data
Articles

BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia

In Collection
Cell death and survival
Gabriela Brumatti, Deeksha Kaloni, Fabíola Attié Castro, Gustavo P. Amarante-Mendes
Journal: Biochemical Journal
Biochem J (2023) 480 (2): 161–176.
https://doi.org/10.1042/BCJ20210608
Published: 31 January 2023
View article titled, BH3 mimetics and TKI combined therapy for Chronic Myeloid Leukemia
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Articles

Dynamic regulation of RAS and RAS signaling

In Collection
Cell signaling in the 21st century
Walter Kolch, Dénes Berta, Edina Rosta
Journal: Biochemical Journal
Biochem J (2023) 480 (1): 1–23.
https://doi.org/10.1042/BCJ20220234
Published: 06 January 2023
View article titled, Dynamic regulation of RAS and RAS signaling
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Articles

Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression

Misun Jung, Wonyoung Kim, Jin Won Cho, Won Ho Yang, In Kwon Chung
Journal: Biochemical Journal
Biochem J (2022) 479 (22): 2379–2394.
https://doi.org/10.1042/BCJ20220391
Published: 30 November 2022
View article titled, Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression
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Includes: Supplementary data
Articles

Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma

Elizabeth M. Black, Yoon Ki Joo, Lilian Kabeche
Journal: Biochemical Journal
Biochem J (2022) 479 (22): 2345–2349.
https://doi.org/10.1042/BCJ20220461
Published: 23 November 2022
View article titled, Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma
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Articles

AMP-activated protein kinase — a journey from 1 to 100 downstream targets

In Collection
Awards
D. Grahame Hardie
Journal: Biochemical Journal
Biochem J (2022) 479 (22): 2327–2343.
https://doi.org/10.1042/BCJ20220255
Published: 16 November 2022
View article titled, AMP-activated protein kinase — a journey from 1 to 100 downstream targets
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Articles

Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

Qian Wei, Kjetil Taskén
Journal: Biochemical Journal
Biochem J (2022) 479 (20): 2219–2260.
https://doi.org/10.1042/BCJ20210233
Published: 28 October 2022
View article titled, Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development
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Articles

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance

Jill E. Hunter, Amy E. Campbell, Jacqueline A. Butterworth, Helene Sellier, Nicola L. Hannaway, Saimir Luli, Achilleas Floudas, Niall S. Kenneth, Adam J. Moore, Philip J. Brownridge, Huw D. Thomas, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Andrew M. Knight, Michelle D. Garrett, Ian Collins, Claire E. Eyers, Neil D. Perkins
Journal: Biochemical Journal
Biochem J (2022) 479 (19): 2087–2113.
https://doi.org/10.1042/BCJ20220089
Published: 14 October 2022
View article titled, Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
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Includes: Supplementary data
Articles

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway

Jill E. Hunter, Amy E. Campbell, Nicola L. Hannaway, Scott Kerridge, Saimir Luli, Jacqueline A. Butterworth, Helene Sellier, Reshmi Mukherjee, Nikita Dhillon, Praveen D. Sudhindar, Ruchi Shukla, Philip J. Brownridge, Hayden L. Bell, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Ian Collins, Michelle D. Garrett, Claire E. Eyers, Neil D. Perkins
Journal: Biochemical Journal
Biochem J (2022) 479 (19): 2063–2086.
https://doi.org/10.1042/BCJ20220102
Published: 14 October 2022
View article titled, Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway
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Includes: Supplementary data
Articles

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells

Jill E. Hunter, Amy E. Campbell, Scott Kerridge, Callum Fraser, Nicola L. Hannaway, Saimir Luli, Iglika Ivanova, Philip J. Brownridge, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S. R. Hasoon, Claire E. Eyers, Neil D. Perkins
Journal: Biochemical Journal
Biochem J (2022) 479 (19): 2131–2151.
https://doi.org/10.1042/BCJ20220103
Published: 14 October 2022
View article titled, Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells
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Includes: Supplementary data
Articles

Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential

Suzanne Madgwick, Saimir Luli, Helene Sellier, Jacqueline A. Butterworth, Jack Leslie, Adam J. Moore, Emma K. Corbin, Adrian I. Yemm, Robson T. Chiremba, Dina Tiniakos, Fiona Oakley, Neil D. Perkins, Jill E. Hunter
Journal: Biochemical Journal
Biochem J (2022) 479 (19): 2115–2130.
https://doi.org/10.1042/BCJ20220101
Published: 14 October 2022
View article titled, Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential
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Includes: Supplementary data
Articles

Combinatorial approaches for mitigating resistance to KRAS-targeted therapies

Hannah R. Warren, Sarah J. Ross, Paul D. Smith, Judy M. Coulson, Ian A. Prior
Journal: Biochemical Journal
Biochem J (2022) 479 (18): 1985–1997.
https://doi.org/10.1042/BCJ20220440
Published: 23 September 2022
View article titled, Combinatorial approaches for mitigating resistance to KRAS-targeted therapies
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Includes: Supplementary data
Articles

Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth

Ksenija Korac, Devaraja Rajasekaran, Tyler Sniegowski, Bradley K. Schniers, Andrew F. Ibrahim, Yangzom D. Bhutia
Journal: Biochemical Journal
Biochem J (2022) 479 (17): 1807–1824.
https://doi.org/10.1042/BCJ20210851
Published: 06 September 2022
View article titled, Carbidopa, an activator of aryl hydrocarbon receptor, suppresses IDO1 expression in pancreatic cancer and decreases tumor growth
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Includes: Supplementary data
Articles

Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells

Gavuthami Murugesan, Alan R. Prescott, Rachel Toth, David G. Campbell, Claire M. Wells, Carol MacKintosh
Journal: Biochemical Journal
Biochem J (2022) 479 (16): 1709–1725.
https://doi.org/10.1042/BCJ20220184
Published: 31 August 2022
View article titled, Differential roles and regulation of the protein kinases PAK4, PAK5 and PAK6 in melanoma cells
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Includes: Supplementary data
Articles

The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?

In Collection
Cell death and survival
Kamil Seyrek, Fabian Wohlfromm, Johannes Espe, Inna N. Lavrik
Journal: Biochemical Journal
Biochem J (2022) 479 (14): 1581–1608.
https://doi.org/10.1042/BCJ20210676
Published: 29 July 2022
View article titled, The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?
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Articles

Identification of ELK1 interacting peptide segments in the androgen receptor

Claire Soave, Charles Ducker, Seongho Kim, Thomas Strahl, Rayna Rosati, Yanfang Huang, Peter E. Shaw, Manohar Ratnam
Journal: Biochemical Journal
Biochem J (2022) 479 (14): 1519–1531.
https://doi.org/10.1042/BCJ20220297
Published: 21 July 2022
View article titled, Identification of ELK1 interacting peptide segments in the androgen receptor
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Includes: Supplementary data
Articles

CORM-3 induces DNA damage through Ru(II) binding to DNA

Rhiannon F. Lyon, Hannah M. Southam, Clare R. Trevitt, Chunyan Liao, Sherif F. El-Khamisy, Robert K. Poole, Mike P. Williamson
Journal: Biochemical Journal
Biochem J (2022) 479 (13): 1429–1439.
https://doi.org/10.1042/BCJ20220254
Published: 04 July 2022
View article titled, CORM-3 induces DNA damage through Ru(II) binding to DNA
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Articles

Distinct interactors define the p63 transcriptional signature in epithelial development or cancer

In Collection
Cell death and survival
Rosalba Pecorari, Francesca Bernassola, Gerry Melino, Eleonora Candi
Journal: Biochemical Journal
Biochem J (2022) 479 (12): 1375–1392.
https://doi.org/10.1042/BCJ20210737
Published: 24 June 2022
View article titled, Distinct interactors define the p63 transcriptional signature in epithelial development or cancer
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Articles

Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure

Hossein Allahmoradi, S. Mohsen Asghari, Atieh Ahmadi, Elham Assareh, Mahboobeh Nazari
Journal: Biochemical Journal
Biochem J (2022) 479 (12): 1285–1302.
https://doi.org/10.1042/BCJ20210830
Published: 21 June 2022
View article titled, Anti-tumor and anti-metastatic activity of the FGF2 118–126 fragment dependent on the loop structure
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Includes: Supplementary data
Articles

NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes

Anne Carine Østvold, Kirsten Grundt, Claudia Wiese
Journal: Biochemical Journal
Biochem J (2022) 479 (11): 1205–1220.
https://doi.org/10.1042/BCJ20220075
Published: 13 June 2022
View article titled, NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes
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Articles

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth

Emily C. Matchett, Elise C. Ambrose, Jacki Kornbluth
Journal: Biochemical Journal
Biochem J (2022) 479 (11): 1149–1164.
https://doi.org/10.1042/BCJ20210770
Published: 08 June 2022
View article titled, Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
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Articles

Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway

In Collection
Cell death and survival
Neil D. Perkins
Journal: Biochemical Journal
Biochem J (2022) 479 (11): 1121–1126.
https://doi.org/10.1042/BCJ20220023
Published: 01 June 2022
View article titled, Alphabetti kinase Spaghetti: the complex roles of IKKα and β in the canonical NF-κB pathway
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Articles

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Bradley K. Schniers, Mitchell S. Wachtel, Meenu Sharma, Ksenija Korac, Devaraja Rajasekaran, Shengping Yang, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia
Journal: Biochemical Journal
Biochem J (2022) 479 (5): 719–730.
https://doi.org/10.1042/BCJ20210855
Published: 16 March 2022
View article titled, Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer
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Articles

Insulin and cancer: a tangled web

In Collection
Celebrating 100 years of insulin research
Brooks P. Leitner, Stephan Siebel, Ngozi D. Akingbesote, Xinyi Zhang, Rachel J. Perry
Journal: Biochemical Journal
Biochem J (2022) 479 (5): 583–607.
https://doi.org/10.1042/BCJ20210134
Published: 04 March 2022
View article titled, Insulin and cancer: a tangled web
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Articles

IKKα plays a major role in canonical NF-κB signalling in colorectal cells

In Collection
Cell death and survival
Jack A. Prescott, Kathryn Balmanno, Jennifer P. Mitchell, Hanneke Okkenhaug, Simon J. Cook
Journal: Biochemical Journal
Biochem J (2022) 479 (3): 305–325.
https://doi.org/10.1042/BCJ20210783
Published: 04 February 2022
View article titled, IKKα plays a major role in canonical NF-κB signalling in colorectal cells
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Includes: Supplementary data
Articles

LASP-1 interacts with ErbB2 in ovarian cancer cells

Chirukandath Sidhanth, Sadhanandhan Bindhya, Aboo Shabna, Shyama Krishnapriya, Pacharla Manasa, Rohit Pravin Nagare, Thanda Joshua, Smarkan Sneha, Kanchan Murhekar, Trivadi Sundaram Ganesan
Journal: Biochemical Journal
Biochem J (2022) 479 (1): 23–38.
https://doi.org/10.1042/BCJ20210173
Published: 06 January 2022
View article titled, LASP-1 interacts with ErbB2 in ovarian cancer cells
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Includes: Supplementary data
Articles

Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane

X. Edward Zhou, Kelly Suino-Powell, Chad R. Schultz, Bilal Aleiwi, Joseph S. Brunzelle, Jared Lamp, Irving E. Vega, Edmund Ellsworth, André S. Bachmann, Karsten Melcher
Journal: Biochemical Journal
Biochem J (2021) 478 (23): 4137–4149.
https://doi.org/10.1042/BCJ20210647
Published: 06 December 2021
View article titled, Structural basis of binding and inhibition of ornithine decarboxylase by 1-amino-oxy-3-aminopropane
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Articles

Regulation of Tim-3 function by binding to phosphatidylserine

Lawrence P. Kane
Journal: Biochemical Journal
Biochem J (2021) 478 (22): 3999–4004.
https://doi.org/10.1042/BCJ20210652
Published: 23 November 2021
View article titled, Regulation of Tim-3 function by binding to phosphatidylserine
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Articles

Expression and function of SLC38A5, an amino acid-coupled Na + /H + exchanger, in triple-negative breast cancer and its relevance to macropinocytosis

Sabarish Ramachandran, Souad R. Sennoune, Monica Sharma, Muthusamy Thangaraju, Varshini V. Suresh, Tyler Sneigowski, Yangzom D. Bhutia, Kevin Pruitt, Vadivel Ganapathy
Journal: Biochemical Journal
Biochem J (2021) 478 (21): 3957–3976.
https://doi.org/10.1042/BCJ20210585
Published: 12 November 2021
View article titled, Expression and function of SLC38A5, an amino acid-coupled Na + /H + exchanger, in triple-negative breast cancer and its relevance to macropinocytosis
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Includes: Supplementary data
Articles

IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles

Nicole M. Naranjo, Israa Salem, Maisha A. Harris, Lucia R. Languino
Journal: Biochemical Journal
Biochem J (2021) 478 (21): 3905–3921.
https://doi.org/10.1042/BCJ20210580
Published: 09 November 2021
View article titled, IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles
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Articles

Meiosis initiation: a story of two sexes in all creatures great and small

Ieng Fong Sou, Rebecca M. Pryce, Wee-Wei Tee, Urszula Lucja McClurg
Journal: Biochemical Journal
Biochem J (2021) 478 (20): 3791–3805.
https://doi.org/10.1042/BCJ20210412
Published: 28 October 2021
View article titled, Meiosis initiation: a story of two sexes in all creatures great and small
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Articles

PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target

Bradley K. Schniers, Devaraja Rajasekaran, Ksenija Korac, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia
Journal: Biochemical Journal
Biochem J (2021) 478 (20): 3757–3774.
https://doi.org/10.1042/BCJ20210377
Published: 21 October 2021
View article titled, PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target
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Includes: Supplementary data
Articles

The unfolding role of ceramide in coordinating retinoid-based cancer therapy

Botheina Ghandour, Ghassan Dbaibo, Nadine Darwiche
Journal: Biochemical Journal
Biochem J (2021) 478 (19): 3621–3642.
https://doi.org/10.1042/BCJ20210368
Published: 14 October 2021
View article titled, The unfolding role of ceramide in coordinating retinoid-based cancer therapy
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Articles

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs

Lung-Yu Liang, Michael Roy, Christopher R. Horne, Jarrod J. Sandow, Minglyanna Surudoi, Laura F. Dagley, Samuel N. Young, Toby Dite, Jeffrey J. Babon, Peter W. Janes, Onisha Patel, James M. Murphy, Isabelle S. Lucet
Journal: Biochemical Journal
Biochem J (2021) 478 (17): 3351–3371.
https://doi.org/10.1042/BCJ20210572
Published: 14 September 2021
View article titled, The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
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Includes: Supplementary data
Articles

The roles of epigenetics in cancer progression and metastasis

Jocelyn F. Chen, Qin Yan
Journal: Biochemical Journal
Biochem J (2021) 478 (17): 3373–3393.
https://doi.org/10.1042/BCJ20210084
Published: 14 September 2021
View article titled, The roles of epigenetics in cancer progression and metastasis
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Articles

PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus

Teddy Kamata, Chun-Song Yang, Bryce M. Paschal
Journal: Biochemical Journal
Biochem J (2021) 478 (15): 2999–3014.
https://doi.org/10.1042/BCJ20210378
Published: 10 August 2021
View article titled, PARP7 mono-ADP-ribosylates the agonist conformation of the androgen receptor in the nucleus
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Articles

Cancer stem cell phosphatases

Majid Momeny, Tiina Arsiola, Jukka Westermarck
Journal: Biochemical Journal
Biochem J (2021) 478 (14): 2899–2920.
https://doi.org/10.1042/BCJ20210254
Published: 28 July 2021
View article titled, Cancer stem cell phosphatases
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Articles

Inhibitory feedback control of NF-κB signalling in health and disease

Jack A. Prescott, Jennifer P. Mitchell, Simon J. Cook
Journal: Biochemical Journal
Biochem J (2021) 478 (13): 2619–2664.
https://doi.org/10.1042/BCJ20210139
Published: 16 July 2021
View article titled, Inhibitory feedback control of NF-κB signalling in health and disease
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Articles

Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability

Ravichandran Vignesh, Anita Sjölander, Ganesh Venkatraman, Suresh Kumar Rayala, Gopala Krishna Aradhyam
Journal: Biochemical Journal
Biochem J (2021) 478 (12): 2265–2283.
https://doi.org/10.1042/BCJ20210016
Published: 18 June 2021
View article titled, Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability
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Includes: Supplementary data
Articles

What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression

Yanel Bernardi, Pablo Hernán Strobl-Mazzulla
Journal: Biochemical Journal
Biochem J (2021) 478 (9): 1809–1825.
https://doi.org/10.1042/BCJ20210083
Published: 14 May 2021
View article titled, What we can learn from embryos to understand the mesenchymal-to-epithelial transition in tumor progression
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Articles

Cancer cachexia: molecular mechanism and pharmacological management

Yonghua Li, Huan Jin, Yibing Chen, Ting Huang, Yanjun Mi, Zhengzhi Zou
Journal: Biochemical Journal
Biochem J (2021) 478 (9): 1663–1688.
https://doi.org/10.1042/BCJ20201009
Published: 10 May 2021
View article titled, Cancer cachexia: molecular mechanism and pharmacological management
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Articles

Anti-glycan antibodies: roles in human disease

J. Sebastian Temme, Dorothy L. Butler, Jeffrey C. Gildersleeve
Journal: Biochemical Journal
Biochem J (2021) 478 (8): 1485–1509.
https://doi.org/10.1042/BCJ20200610
Published: 21 April 2021
View article titled, Anti-glycan antibodies: roles in human disease
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