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Articles

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase

Nicholas Purser, Ishita Tripathi-Giesgen, Jerry Li, Daniel C. Scott, Daniel Horn-Ghetko, Kheewoong Baek, Brenda A. Schulman, Arno F. Alpi, Gary Kleiger

Biochem J (2023) 480 (22): 1817–1831.

https://doi.org/10.1042/BCJ20230373

Published: 17 November 2023

View article titled, Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase

Includes: Supplementary data

Articles

Activating mutations drive human MEK1 kinase using a gear-shifting mechanism

Keshav Patil, Yiming Wang, Zhangtao Chen, Krishna Suresh, Ravi Radhakrishnan

Biochem J (2023) 480 (21): 1733–1751.

https://doi.org/10.1042/BCJ20230281

Published: 02 November 2023

View article titled, Activating mutations drive human MEK1 kinase using a gear-shifting mechanism

Articles

RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers

Shanshan Tian, Xiaowei Zhong, Hui Wang, Jinhong Wei, Wenting Guo, Ruiwu Wang, John Paul Estillore, Carlo Napolitano, Henry H. Duff, Erkan Ilhan, Linda M. Knight, Michael S. Lloyd, Jason D. Roberts, Silvia G. Priori, S.R. Wayne Chen

Biochem J (2023) 480 (17): 1379–1395.

https://doi.org/10.1042/BCJ20230254

Published: 01 September 2023

View article titled, RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers

Articles

Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues

Kyler A. Weingartner, Thao Tran, Katherine W. Tripp, Jennifer M. Kavran

Biochem J (2023) 480 (15): 1165–1182.

https://doi.org/10.1042/BCJ20230067

Published: 27 July 2023

View article titled, Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues

Includes: Supplementary data

Articles

Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43

Tianhe Li, Honghong Chen, Xiaole Li, Peter B. Stathopulos, Donglin Bai

Biochem J (2023) 480 (14): 1051–1077.

https://doi.org/10.1042/BCJ20230081

Published: 17 July 2023

View article titled, Inherited disease-linked arginine76/75 mutants in Cx50 and Cx45 showed impaired homotypic and heterotypic gap junction function, but not Cx43

Articles

Self-assembly of shell protein and native enzyme in a crowded environment leads to catalytically active phase condensates

Gaurav Kumar, Sharmistha Sinha

Biochem J (2023) 480 (8): 539–553.

https://doi.org/10.1042/BCJ20220551

Published: 26 April 2023

View article titled, Self-assembly of shell protein and native enzyme in a crowded environment leads to catalytically active phase condensates

Includes: Multimedia, Supplementary data

Articles

From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I

In Collection

Awards

Leonid A. Sazanov

Biochem J (2023) 480 (5): 319–333.

https://doi.org/10.1042/BCJ20210285

Published: 15 March 2023

View article titled, From the ‘black box' to ‘domino effect' mechanism: what have we learned from the structures of respiratory complex I

Includes: Multimedia, Supplementary data

Articles

From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics

In Collection

Cell signaling in the 21st century

Donald E. Ingber

Biochem J (2023) 480 (4): 243–257.

https://doi.org/10.1042/BCJ20220303

Published: 23 February 2023

View article titled, From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics

Articles

Dynamic regulation of RAS and RAS signaling

In Collection

Cell signaling in the 21st century

Walter Kolch, Dénes Berta, Edina Rosta

Biochem J (2023) 480 (1): 1–23.

https://doi.org/10.1042/BCJ20220234

Published: 06 January 2023

View article titled, Dynamic regulation of RAS and RAS signaling

Articles

Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity

Foteini Bartzoka, Monica Gonzalez-Magaldi, Patrick O. Byrne, Nicole I. Callery, Kalina Hristova, Daniel J. Leahy

Biochem J (2022) 479 (24): 2465–2475.

https://doi.org/10.1042/BCJ20220472

Published: 19 December 2022

View article titled, Activity of EGFR transmembrane region variants indicates specific transmembrane dimers are not required for EGFR activity

Includes: Supplementary data

Articles

Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2

In Collection

Coronavirus

Cameron Lee Shetler, Juliana C. Ferreira, Thyago H. S. Cardoso, Edson M.A. Silva, Nitin K. Saksena, Wael M. Rabeh

Biochem J (2022) 479 (20): 2175–2193.

https://doi.org/10.1042/BCJ20220380

Published: 21 October 2022

View article titled, Therapeutic potential of metal ions for COVID-19: insights from the papain-like protease of SARS-CoV-2

Articles

The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin

Mei Nakagawa, Takayuki Obita, Mineyuki Mizuguchi

Biochem J (2022) 479 (18): 1999–2011.

https://doi.org/10.1042/BCJ20220203

Published: 30 September 2022

View article titled, The hydrophobic residue Leu73 is crucial for the high stability and low aggregation properties of murine transthyretin

Includes: Supplementary data

Articles

Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain

Pravin S. Dewangan, Tsebaot G. Beraki, E. Ariana Paiz, Delia Appiah Mensah, Zhe Chen, Michael L. Reese

Biochem J (2022) 479 (17): 1877–1889.

https://doi.org/10.1042/BCJ20220076

Published: 16 September 2022

View article titled, Divergent kinase WNG1 is regulated by phosphorylation of an atypical activation sub-domain

Includes: Supplementary data

Articles

Cryo-EM structure of human MG53 homodimer

Yange Niu, Gengjia Chen, Fengxiang Lv, Rui-Ping Xiao, Xinli Hu, Lei Chen

Biochem J (2022) 479 (17): 1909–1916.

https://doi.org/10.1042/BCJ20220385

Published: 16 September 2022

View article titled, Cryo-EM structure of human MG53 homodimer

Includes: Supplementary data

Articles

How do cells stiffen?

Peter A. Galie, Penelope C. Georges, Paul A. Janmey

Biochem J (2022) 479 (17): 1825–1842.

https://doi.org/10.1042/BCJ20210806

Published: 12 September 2022

View article titled, How do cells stiffen?

Articles

Thermodynamic analysis of Zα domain-nucleic acid interactions

Bharath Srinivasan, Krzysztof Kuś, Alekos Athanasiadis

Biochem J (2022) 479 (16): 1727–1741.

https://doi.org/10.1042/BCJ20220200

Published: 31 August 2022

View article titled, Thermodynamic analysis of Zα domain-nucleic acid interactions

Includes: Supplementary data

Articles

Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity

Athira Pushpakaran, Rachana Rao Battaje, Dulal Panda

Biochem J (2022) 479 (14): 1543–1558.

https://doi.org/10.1042/BCJ20220077

Published: 21 July 2022

View article titled, Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in Streptococcus pneumoniae and displays anti-pneumococcal activity

Includes: Supplementary data

Articles

Highly sensitive tryptophan fluorescence probe for detecting rhythmic conformational changes of KaiC in the cyanobacterial circadian clock system

In Collection

Towards systems biochemistry

Atsushi Mukaiyama, Yoshihiko Furuike, Eiki Yamashita, Shuji Akiyama

Biochem J (2022) 479 (14): 1505–1515.

https://doi.org/10.1042/BCJ20210544

Published: 19 July 2022

View article titled, Highly sensitive tryptophan fluorescence probe for detecting rhythmic conformational changes of KaiC in the cyanobacterial circadian clock system

Includes: Supplementary data

Articles

Binding partners regulate unfolding of myosin VI to activate the molecular motor

Ália dos Santos, Natalia Fili, Yukti Hari-Gupta, Rosemarie E. Gough, Lin Wang, Marisa Martin-Fernandez, Jesse Aaron, Eric Wait, Teng-Leong Chew, Christopher P. Toseland

Biochem J (2022) 479 (13): 1409–1428.

https://doi.org/10.1042/BCJ20220025

Published: 04 July 2022

View article titled, Binding partners regulate unfolding of myosin VI to activate the molecular motor

Includes: Supplementary data

Articles

A structural approach to understanding enzymatic regulation of chemical reaction networks

In Collection

Towards systems biochemistry

Atsushi Mochizuki

Biochem J (2022) 479 (11): 1265–1283.

https://doi.org/10.1042/BCJ20210545

Published: 17 June 2022

View article titled, A structural approach to understanding enzymatic regulation of chemical reaction networks

Articles

Integration of machine learning with computational structural biology of plants

Jiming Chen, Diwakar Shukla

Biochem J (2022) 479 (8): 921–928.

https://doi.org/10.1042/BCJ20200942

Published: 29 April 2022

View article titled, Integration of machine learning with computational structural biology of plants

Articles

Allosteric pluripotency: challenges and opportunities

Madoka Akimoto, Karla Martinez Pomier, Bryan VanSchouwen, Jung Ah Byun, Mariia Khamina, Giuseppe Melacini

Biochem J (2022) 479 (7): 825–838.

https://doi.org/10.1042/BCJ20210528

Published: 11 April 2022

View article titled, Allosteric pluripotency: challenges and opportunities

Articles

α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif

Matthew Batchelor, Robert S. Dawber, Andrew J. Wilson, Richard Bayliss

Biochem J (2022) 479 (5): 687–700.

https://doi.org/10.1042/BCJ20210812

Published: 16 March 2022

View article titled, α-Helix stabilization by co-operative side chain charge-reinforced interactions to phosphoserine in a basic kinase-substrate motif

Includes: Supplementary data

Articles

Quantifying the long-term interplay between photoprotection and repair mechanisms sustaining photosystem II activity

In Collection

Plants and climate change: the role of plants in achieving net zero

Francesco Saccon, Sam Wilson, Felix S. Morey-Burrows, Alexander V. Ruban

Biochem J (2022) 479 (5): 701–717.

https://doi.org/10.1042/BCJ20220031

Published: 16 March 2022

View article titled, Quantifying the long-term interplay between photoprotection and repair mechanisms sustaining photosystem II activity

Includes: Supplementary data

Articles

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Zhuoyao Chen, Jinwei Zhang, Adrián R. Murillo-de-Ozores, María Castañeda-Bueno, Francesca D'Amico, Raphael Heilig, Charlotte E. Manning, Fiona J. Sorrell, Vincenzo D'Angiolella, Roman Fischer, Monique P. C. Mulder, Gerardo Gamba, Dario R. Alessi, Alex N. Bullock

Biochem J (2022) 479 (5): 661–675.

https://doi.org/10.1042/BCJ20220019

Published: 04 March 2022

View article titled, Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

Includes: Supplementary data

Articles

N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Samuel Pazicky, Arne Alder, Haydyn Mertens, Dmitri Svergun, Tim Gilberger, Christian Löw

Biochem J (2022) 479 (3): 337–356.

https://doi.org/10.1042/BCJ20210829

Published: 04 February 2022

View article titled, N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Includes: Supplementary data

Articles

Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly

Yashwanth Ashok, Carlos Vela-Rodríguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö

Biochem J (2022) 479 (3): 289–304.

https://doi.org/10.1042/BCJ20210722

Published: 04 February 2022

View article titled, Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly

Includes: Supplementary data

Articles

Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

In Collection

Towards systems biochemistry

Tsuyoshi Hirashima

Biochem J (2022) 479 (2): 129–143.

https://doi.org/10.1042/BCJ20210557

Published: 20 January 2022

View article titled, Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

Articles

Electron transfer via cytochrome b 6 f complex displays sensitivity to antimycin A upon STT7 kinase activation

Felix Buchert, Martin Scholz, Michael Hippler

Biochem J (2022) 479 (1): 111–127.

https://doi.org/10.1042/BCJ20210802

Published: 14 January 2022

View article titled, Electron transfer via cytochrome b 6 f complex displays sensitivity to antimycin A upon STT7 kinase activation

Includes: Supplementary data

Articles

Making protons tag along with electrons

Matthew J. Guberman-Pfeffer, Nikhil S. Malvankar

Biochem J (2021) 478 (23): 4093–4097.

https://doi.org/10.1042/BCJ20210592

Published: 06 December 2021

View article titled, Making protons tag along with electrons

Articles

Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 Å: the structural basis for dimerisation

Pu Qian, Tristan I. Croll, Andrew Hitchcock, Philip J. Jackson, Jack H. Salisbury, Pablo Castro-Hartmann, Kasim Sader, David J.K. Swainsbury, C. Neil Hunter

Biochem J (2021) 478 (21): 3923–3937.

https://doi.org/10.1042/BCJ20210696

Published: 09 November 2021

View article titled, Cryo-EM structure of the dimeric Rhodobacter sphaeroides RC-LH1 core complex at 2.9 Å: the structural basis for dimerisation

Includes: Supplementary data

Articles

Thermostability-based binding assays reveal complex interplay of cation, substrate and lipid binding in the bacterial DASS transporter, VcINDY

Connor D. D. Sampson, Cristina Fàbregas Bellavista, Matthew J. Stewart, Christopher Mulligan

Biochem J (2021) 478 (21): 3847–3867.

https://doi.org/10.1042/BCJ20210061

Published: 09 November 2021

View article titled, Thermostability-based binding assays reveal complex interplay of cation, substrate and lipid binding in the bacterial DASS transporter, VcINDY

Includes: Supplementary data

Articles

Quantitative characterization of tetraspanin 8 homointeractions in the plasma membrane

Daniel Wirth, Ece Özdemir, Christopher King, Lena Ahlswede, Dirk Schneider, Kalina Hristova

Biochem J (2021) 478 (19): 3643–3654.

https://doi.org/10.1042/BCJ20210459

Published: 14 October 2021

View article titled, Quantitative characterization of tetraspanin 8 homointeractions in the plasma membrane

Articles

Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Muhammad Faheem, Napoleão Fonseca Valadares, José Brandão-Neto, Dom Bellini, Patrick Collins, Nicholas M. Pearce, Louise Bird, Juliana Roberta Torini, Raymond Owens, Humberto DMuniz Pereira, Frank Von Delft, João Alexandre Ribeiro Gonçalves Barbosa

Biochem J (2021) 478 (19): 3655–3670.

https://doi.org/10.1042/BCJ20210041

Published: 14 October 2021

View article titled, Crystallographic approach to fragment-based hit discovery against Schistosoma mansoni purine nucleoside phosphorylase

Articles

Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen

Jennifer M. Crowther, Letitia H. Gilmour, Benjamin T. Porebski, Sarah G. Heath, Neil R. Pattinson, Maurice C. Owen, Rayleen Fredericks, Ashley M. Buckle, Conan J. Fee, Christoph Göbl, Renwick C. J. Dobson

Biochem J (2021) 478 (17): 3319–3330.

https://doi.org/10.1042/BCJ20210476

Published: 14 September 2021

View article titled, Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen

Articles

Electron inventory of the iron-sulfur scaffold complex HypCD essential in [NiFe]-hydrogenase cofactor assembly

Sven T. Stripp, Jonathan Oltmanns, Christina S. Müller, David Ehrenberg, Ramona Schlesinger, Joachim Heberle, Lorenz Adrian, Volker Schünemann, Antonio J. Pierik, Basem Soboh

Biochem J (2021) 478 (17): 3281–3295.

https://doi.org/10.1042/BCJ20210224

Published: 07 September 2021

View article titled, Electron inventory of the iron-sulfur scaffold complex HypCD essential in [NiFe]-hydrogenase cofactor assembly

Includes: Supplementary data

Articles

The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding

Lior Pytowski, David J. Vaux, Létitia Jean

Biochem J (2021) 478 (15): 3025–3046.

https://doi.org/10.1042/BCJ20210384

Published: 13 August 2021

View article titled, The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding

Includes: Multimedia, Supplementary data

Articles

Per aspera ad chaos : a personal journey to the wonderland of intrinsic disorder

Vladimir N. Uversky

Biochem J (2021) 478 (15): 3015–3024.

https://doi.org/10.1042/BCJ20210146

Published: 10 August 2021

View article titled, Per aspera ad chaos : a personal journey to the wonderland of intrinsic disorder

Articles

Mapping the interaction surface of scorpion β-toxins with an insect sodium channel

Boris S. Zhorov, Yuzhe Du, Weizhong Song, Ningguang Luo, Dalia Gordon, Michael Gurevitz, Ke Dong

Biochem J (2021) 478 (14): 2843–2869.

https://doi.org/10.1042/BCJ20210336

Published: 23 July 2021

View article titled, Mapping the interaction surface of scorpion β-toxins with an insect sodium channel

Includes: Supplementary data

Articles

Rational design of electron/proton transfer mechanisms in the exoelectrogenic bacteria Geobacter sulfurreducens

Marta A. Silva, Pilar C. Portela, Carlos A. Salgueiro

Biochem J (2021) 478 (14): 2871–2887.

https://doi.org/10.1042/BCJ20210365

Published: 23 July 2021

View article titled, Rational design of electron/proton transfer mechanisms in the exoelectrogenic bacteria Geobacter sulfurreducens

Includes: Supplementary data

Articles

Conformational plasticity of the ULK3 kinase domain

Sebastian Mathea, Eidarus Salah, Cynthia Tallant, Deep Chatterjee, Benedict-Tilman Berger, Rebecca Konietzny, Susanne Müller, Benedikt M. Kessler, Stefan Knapp

Biochem J (2021) 478 (14): 2811–2823.

https://doi.org/10.1042/BCJ20210257

Published: 23 July 2021

View article titled, Conformational plasticity of the ULK3 kinase domain

Includes: Supplementary data

Articles

The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands

Neda S. Kazemein Jasemi, Christian Herrmann, Eva Magdalena Estirado, Lothar Gremer, Dieter Willbold, Luc Brunsveld, Radovan Dvorsky, Mohammad R. Ahmadian

Biochem J (2021) 478 (14): 2793–2809.

https://doi.org/10.1042/BCJ20210105

Published: 23 July 2021

View article titled, The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands

Includes: Supplementary data

Articles

Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha

Hamine C. de Oliveira, Tainá D. da Silva, Guilherme H. M. Salvador, Ivan R. Moraes, Cíntia A. Fukuda, Andrea C. de Barros, Marcos R. M. Fontes

Biochem J (2021) 478 (13): 2715–2732.

https://doi.org/10.1042/BCJ20210401

Published: 16 July 2021

View article titled, Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha

Articles

The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii

Carolina Conter, Luca Bombardi, Marco Pedretti, Filippo Favretto, Adele Di Matteo, Paola Dominici, Alessandra Astegno

Biochem J (2021) 478 (13): 2571–2587.

https://doi.org/10.1042/BCJ20210295

Published: 09 July 2021

View article titled, The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii

Includes: Supplementary data

Articles

Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability

Ravichandran Vignesh, Anita Sjölander, Ganesh Venkatraman, Suresh Kumar Rayala, Gopala Krishna Aradhyam

Biochem J (2021) 478 (12): 2265–2283.

https://doi.org/10.1042/BCJ20210016

Published: 18 June 2021

View article titled, Aberrant environment and PS-binding to calnuc C-terminal tail drives exosomal packaging and its metastatic ability

Includes: Supplementary data

Articles

Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions

Ali Imran, Brandon S. Moyer, Ashley J. Canning, Dan Kalina, Thomas M. Duncan, Kelsey J. Moody, Aaron J. Wolfe, Michael S. Cosgrove, Liviu Movileanu

Biochem J (2021) 478 (11): 2145–2161.

https://doi.org/10.1042/BCJ20210253

Published: 11 June 2021

View article titled, Kinetics of the multitasking high-affinity Win binding site of WDR5 in restricted and unrestricted conditions

Includes: Supplementary data

Articles

On the specificity of protein–protein interactions in the context of disorder

Kaare Teilum, Johan G. Olsen, Birthe B. Kragelund

Biochem J (2021) 478 (11): 2035–2050.

https://doi.org/10.1042/BCJ20200828

Published: 08 June 2021

View article titled, On the specificity of protein–protein interactions in the context of disorder

Articles

Conformational changes during the reaction cycle of plasma membrane Ca 2+ -ATPase in the autoinhibited and activated states

Nicolás A. Saffioti, Marilina de Sautu, Ana Sol Riesco, Mariela S. Ferreira-Gomes, Juan Pablo F. C. Rossi, Irene C. Mangialavori

Biochem J (2021) 478 (10): 2019–2034.

https://doi.org/10.1042/BCJ20210036

Published: 28 May 2021

View article titled, Conformational changes during the reaction cycle of plasma membrane Ca 2+ -ATPase in the autoinhibited and activated states

Includes: Supplementary data

Articles

The breakthrough in protein structure prediction

Andrei N. Lupas, Joana Pereira, Vikram Alva, Felipe Merino, Murray Coles, Marcus D. Hartmann

Biochem J (2021) 478 (10): 1885–1890.

https://doi.org/10.1042/BCJ20200963

Published: 24 May 2021

View article titled, The breakthrough in protein structure prediction

Articles

Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4

Hunmin Jung, Seongmin Lee

Biochem J (2021) 478 (9): 1769–1781.

https://doi.org/10.1042/BCJ20210162

Published: 10 May 2021

View article titled, Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4

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