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Articles

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

In Collection

Catia L. Pierotti, Annette V. Jacobsen, Christoph Grohmann, Ruby K. Dempsey, Nima Etemadi, Joanne M. Hildebrand, Cheree Fitzgibbon, Samuel N. Young, Katherine A. Davies, Wilhelmus J. A. Kersten, John Silke, Kym N. Lowes, Hélène Jousset Sabroux, David C. S. Huang, Mark F. van Delft, James M. Murphy, Guillaume Lessene

Biochem J (2023) 480 (9): 665–684.

DOI: https://doi.org/10.1042/BCJ20230035

Published: 12 May 2023

View article titled, The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

Articles

Principles of phosphoproteomics and applications in cancer research

In Collection

Cell signaling in the 21st century

Luke Higgins, Henry Gerdes, Pedro R. Cutillas

Biochem J (2023) 480 (6): 403–420.

DOI: https://doi.org/10.1042/BCJ20220220

Published: 24 March 2023

View article titled, Principles of phosphoproteomics and applications in cancer research

Articles

Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Edwin T. Gibbs, II, Chad A. Lerner, Mark A. Watson, Hoi-Shan Wong, Akos A. Gerencser, Martin D. Brand

Biochem J (2023) 480 (5): 363–384.

DOI: https://doi.org/10.1042/BCJ20220611

Published: 15 March 2023

View article titled, Site I Q in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions

Articles

Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry

Karin Murakami, Ryo Tamura, Sanae Ikehara, Hayato Ota, Tomomi Ichimiya, Naoki Matsumoto, Hisahiro Matsubara, Shoko Nishihara, Yuzuru Ikehara, Kazuo Yamamoto

Biochem J (2023) 480 (1): 41–56.

DOI: https://doi.org/10.1042/BCJ20220339

Published: 06 January 2023

View article titled, Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry

Includes: Supplementary data

Articles

Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12

Elisha H. McCrory, Vyacheslav Akimov, Philip Cohen, Blagoy Blagoev

Biochem J (2022) 479 (23): 2419–2431.

DOI: https://doi.org/10.1042/BCJ20220510

Published: 07 December 2022

View article titled, Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12

Includes: Supplementary data

Articles

Common and unique features of glycosylation and glycosyltransferases in African trypanosomes

Samuel M. Duncan, Michael A.J. Ferguson

Biochem J (2022) 479 (17): 1743–1758.

DOI: https://doi.org/10.1042/BCJ20210778

Published: 06 September 2022

View article titled, Common and unique features of glycosylation and glycosyltransferases in African trypanosomes

Articles

The function of BK channels extracted and purified within SMALPs

Jaimin H. Patel, Naomi L. Pollock, Jacqueline Maher, Alice J. Rothnie, Marcus C. Allen

Biochem J (2022) 479 (15): 1609–1619.

DOI: https://doi.org/10.1042/BCJ20210628

Published: 05 August 2022

View article titled, The function of BK channels extracted and purified within SMALPs

Includes: Supplementary data

Articles

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Biochem J (2022) 479 (11): 1181–1204.

DOI: https://doi.org/10.1042/BCJ20220067

Published: 08 June 2022

View article titled, Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Includes: Supplementary data

Articles

Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity

In Collection

Coronavirus

Gavin D. Garland, Robert F. Harvey, Thomas E. Mulroney, Mie Monti, Stewart Fuller, Richard Haigh, Pehuén Pereyra Gerber, Michael R. Barer, Nicholas J. Matheson, Anne E. Willis

Biochem J (2022) 479 (8): 901–920.

DOI: https://doi.org/10.1042/BCJ20220105

Published: 21 April 2022

View article titled, Development of a colorimetric assay for the detection of SARS-CoV-2 3CLpro activity

Includes: Supplementary data

Articles

Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

Karen M. Dunkerley, Anne C. Rintala-Dempsey, Giulia Salzano, Roya Tadayon, Dania Hadi, Kathryn R. Barber, Helen Walden, Gary S. Shaw

Biochem J (2022) 479 (6): 751–766.

DOI: https://doi.org/10.1042/BCJ20210741

Published: 28 March 2022

View article titled, Distinct phosphorylation signals drive acceptor versus free ubiquitin chain targeting by parkin

Includes: Supplementary data

Articles

Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Bradley K. Schniers, Mitchell S. Wachtel, Meenu Sharma, Ksenija Korac, Devaraja Rajasekaran, Shengping Yang, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia

Biochem J (2022) 479 (5): 719–730.

DOI: https://doi.org/10.1042/BCJ20210855

Published: 16 March 2022

View article titled, Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Articles

TAT–RHIM: a more complex issue than expected

In Collection

Cell death and survival

Benedikt Kolbrink, Theresa Riebeling, Nikolas K. Teiwes, Claudia Steinem, Hubert Kalbacher, Ulrich Kunzendorf, Stefan Krautwald

Biochem J (2022) 479 (3): 259–272.

DOI: https://doi.org/10.1042/BCJ20210677

Published: 04 February 2022

View article titled, TAT–RHIM: a more complex issue than expected

Articles

Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly

Yashwanth Ashok, Carlos Vela-Rodríguez, Chunsong Yang, Heli I. Alanen, Fan Liu, Bryce M. Paschal, Lari Lehtiö

Biochem J (2022) 479 (3): 289–304.

DOI: https://doi.org/10.1042/BCJ20210722

Published: 04 February 2022

View article titled, Reconstitution of the DTX3L–PARP9 complex reveals determinants for high-affinity heterodimerization and multimeric assembly

Includes: Supplementary data

Articles

Conformational trapping of an ABC transporter in polymer lipid nanoparticles

Naomi L. Pollock, James Lloyd, Carlotta Montinaro, Megha Rai, Timothy R. Dafforn

Biochem J (2022) 479 (2): 145–159.

DOI: https://doi.org/10.1042/BCJ20210312

Published: 20 January 2022

View article titled, Conformational trapping of an ABC transporter in polymer lipid nanoparticles

Includes: Supplementary data

Articles

Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

In Collection

Towards systems biochemistry

Tsuyoshi Hirashima

Biochem J (2022) 479 (2): 129–143.

DOI: https://doi.org/10.1042/BCJ20210557

Published: 20 January 2022

View article titled, Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

Articles

SLC26A9 is selected for endoplasmic reticulum associated degradation (ERAD) via Hsp70-dependent targeting of the soluble STAS domain

Patrick G. Needham, Jennifer L. Goeckeler-Fried, Casey Zhang, Zhihao Sun, Adam R. Wetzel, Carol A. Bertrand, Jeffrey L. Brodsky

Biochem J (2021) 478 (24): 4203–4220.

DOI: https://doi.org/10.1042/BCJ20210644

Published: 23 December 2021

View article titled, SLC26A9 is selected for endoplasmic reticulum associated degradation (ERAD) via Hsp70-dependent targeting of the soluble STAS domain

Includes: Supplementary data

Articles

New tools for automated cryo-EM single-particle analysis in RELION-4.0

In Collection

Awards

Dari Kimanius, Liyi Dong, Grigory Sharov, Takanori Nakane, Sjors H. W. Scheres

Biochem J (2021) 478 (24): 4169–4185.

DOI: https://doi.org/10.1042/BCJ20210708

Published: 16 December 2021

View article titled, New tools for automated cryo-EM single-particle analysis in RELION-4.0

Articles

Signalling dynamics in embryonic development

Katharina F. Sonnen, Claudia Y. Janda

Biochem J (2021) 478 (23): 4045–4070.

DOI: https://doi.org/10.1042/BCJ20210043

Published: 06 December 2021

View article titled, Signalling dynamics in embryonic development

Articles

PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target

Bradley K. Schniers, Devaraja Rajasekaran, Ksenija Korac, Tyler Sniegowski, Vadivel Ganapathy, Yangzom D. Bhutia

Biochem J (2021) 478 (20): 3757–3774.

DOI: https://doi.org/10.1042/BCJ20210377

Published: 21 October 2021

View article titled, PEPT1 is essential for the growth of pancreatic cancer cells: a viable drug target

Includes: Supplementary data

Articles

Stepwise oxidations play key roles in the structural and functional regulations of DJ-1

In-Kang Song, Mi-Sun Kim, James E. Ferrell Jr., Dong-Hae Shin, Kong-Joo Lee

Biochem J (2021) 478 (19): 3505–3525.

DOI: https://doi.org/10.1042/BCJ20210245

Published: 06 October 2021

View article titled, Stepwise oxidations play key roles in the structural and functional regulations of DJ-1

Includes: Supplementary data

Articles

Investigation of sequon engineering for improved O-glycosylation by the human polypeptide N-acetylgalactosaminyl transferase T2 isozyme and two orthologues

Nicole K. Thompson, Leif T. N. LeClaire, Samantha Rodriguez Perez, Warren W. Wakarchuk

Biochem J (2021) 478 (19): 3527–3537.

DOI: https://doi.org/10.1042/BCJ20210382

Published: 06 October 2021

View article titled, Investigation of sequon engineering for improved O-glycosylation by the human polypeptide N-acetylgalactosaminyl transferase T2 isozyme and two orthologues

Includes: Supplementary data

Articles

The BRCA1/BARD1 ubiquitin ligase and its substrates

Samuel R. Witus, Mikaela D. Stewart, Rachel E. Klevit

Biochem J (2021) 478 (18): 3467–3483.

DOI: https://doi.org/10.1042/BCJ20200864

Published: 30 September 2021

View article titled, The BRCA1/BARD1 ubiquitin ligase and its substrates

Articles

Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen

Jennifer M. Crowther, Letitia H. Gilmour, Benjamin T. Porebski, Sarah G. Heath, Neil R. Pattinson, Maurice C. Owen, Rayleen Fredericks, Ashley M. Buckle, Conan J. Fee, Christoph Göbl, Renwick C. J. Dobson

Biochem J (2021) 478 (17): 3319–3330.

DOI: https://doi.org/10.1042/BCJ20210476

Published: 14 September 2021

View article titled, Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen

Articles

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs

Lung-Yu Liang, Michael Roy, Christopher R. Horne, Jarrod J. Sandow, Minglyanna Surudoi, Laura F. Dagley, Samuel N. Young, Toby Dite, Jeffrey J. Babon, Peter W. Janes, Onisha Patel, James M. Murphy, Isabelle S. Lucet

Biochem J (2021) 478 (17): 3351–3371.

DOI: https://doi.org/10.1042/BCJ20210572

Published: 14 September 2021

View article titled, The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs

Includes: Supplementary data

Articles

Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli

Saurabh Sharma, Ramesh Kumar, Ayushi Jain, Manoj Kumar, Rahul Gauttam, Rajdeep Banerjee, Jayanta Mukhopadhyay, Jaya Sivaswami Tyagi

Biochem J (2021) 478 (16): 3079–3098.

DOI: https://doi.org/10.1042/BCJ20210268

Published: 20 August 2021

View article titled, Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli

Includes: Supplementary data

Articles

The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding

Lior Pytowski, David J. Vaux, Létitia Jean

Biochem J (2021) 478 (15): 3025–3046.

DOI: https://doi.org/10.1042/BCJ20210384

Published: 13 August 2021

View article titled, The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding

Includes: Multimedia, Supplementary data

Articles

The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands

Neda S. Kazemein Jasemi, Christian Herrmann, Eva Magdalena Estirado, Lothar Gremer, Dieter Willbold, Luc Brunsveld, Radovan Dvorsky, Mohammad R. Ahmadian

Biochem J (2021) 478 (14): 2793–2809.

DOI: https://doi.org/10.1042/BCJ20210105

Published: 23 July 2021

View article titled, The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands

Includes: Supplementary data

Articles

SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization

Alexandra D. Gurzau, Christopher R. Horne, Yee-Foong Mok, Megan Iminitoff, Tracy A. Willson, Samuel N. Young, Marnie E. Blewitt, James M. Murphy

Biochem J (2021) 478 (13): 2555–2569.

DOI: https://doi.org/10.1042/BCJ20210278

Published: 09 July 2021

View article titled, SMCHD1's ubiquitin-like domain is required for N-terminal dimerization and chromatin localization

Includes: Supplementary data

Articles

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

In Collection

Coronavirus , Tackling SARS-CoV-2 biochemistry

Jingkun Zeng, Florian Weissmann, Agustina P. Bertolin, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C. Milligan, Chloe Roustan, Annabel Borg, Laura McCoy, Lucy S. Drury, Svend Kjaer, John McCauley, Michael Howell, Rupert Beale, John F.X. Diffley

Biochem J (2021) 478 (13): 2405–2423.

DOI: https://doi.org/10.1042/BCJ20210201

Published: 02 July 2021

View article titled, Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

Includes: Supplementary data

Articles

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

In Collection

Coronavirus , Tackling SARS-CoV-2 biochemistry

Agustina P. Bertolin, Florian Weissmann, Jingkun Zeng, Viktor Posse, Jennifer C. Milligan, Berta Canal, Rachel Ulferts, Mary Wu, Lucy S. Drury, Michael Howell, Rupert Beale, John F.X. Diffley

Biochem J (2021) 478 (13): 2425–2443.

DOI: https://doi.org/10.1042/BCJ20210200

Published: 02 July 2021

View article titled, Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase

Includes: Supplementary data

Articles

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

In Collection

Coronavirus , Tackling SARS-CoV-2 biochemistry

Berta Canal, Ryo Fujisawa, Allison W. McClure, Tom D. Deegan, Mary Wu, Rachel Ulferts, Florian Weissmann, Lucy S. Drury, Agustina P. Bertolin, Jingkun Zeng, Rupert Beale, Michael Howell, Karim Labib, John F.X. Diffley

Biochem J (2021) 478 (13): 2465–2479.

DOI: https://doi.org/10.1042/BCJ20210199

Published: 02 July 2021

View article titled, Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease

Includes: Supplementary data

Articles

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

In Collection

Coronavirus , Tackling SARS-CoV-2 biochemistry

Chew Theng Lim, Kang Wei Tan, Mary Wu, Rachel Ulferts, Lee A. Armstrong, Eiko Ozono, Lucy S. Drury, Jennifer C. Milligan, Theresa U. Zeisner, Jingkun Zeng, Florian Weissmann, Berta Canal, Ganka Bineva-Todd, Michael Howell, Nicola O'Reilly, Rupert Beale, Yogesh Kulathu, Karim Labib, John F.X. Diffley

Biochem J (2021) 478 (13): 2517–2531.

DOI: https://doi.org/10.1042/BCJ20210244

Published: 02 July 2021

View article titled, Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease

Includes: Supplementary data

Articles

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease

In Collection

Coronavirus , Tackling SARS-CoV-2 biochemistry

Biochem J (2021) 478 (13): 2499–2515.

DOI: https://doi.org/10.1042/BCJ20210197

Published: 02 July 2021

View article titled, Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease

Includes: Supplementary data

Articles

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

In Collection

Coronavirus , Tackling SARS-CoV-2 biochemistry

Biochem J (2021) 478 (13): 2481–2497.

DOI: https://doi.org/10.1042/BCJ20210219

Published: 02 July 2021

View article titled, Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

Includes: Supplementary data

Articles

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

In Collection

Coronavirus , Tackling SARS-CoV-2 biochemistry

Berta Canal, Allison W. McClure, Joseph F. Curran, Mary Wu, Rachel Ulferts, Florian Weissmann, Jingkun Zeng, Agustina P. Bertolin, Jennifer C. Milligan, Souradeep Basu, Lucy S. Drury, Tom D. Deegan, Ryo Fujisawa, Emma L. Roberts, Clovis Basier, Karim Labib, Rupert Beale, Michael Howell, John F.X. Diffley

Biochem J (2021) 478 (13): 2445–2464.

DOI: https://doi.org/10.1042/BCJ20210198

Published: 02 July 2021

View article titled, Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

Includes: Supplementary data

Articles

Evaluation of artificial signal peptides for secretion of two lysosomal enzymes in CHO cells

Kai-Wen Cheng, Feng Wang, George A. Lopez, Srikanth Singamsetty, Jill Wood, Patricia I. Dickson, Tsui-Fen Chou

Biochem J (2021) 478 (12): 2309–2319.

DOI: https://doi.org/10.1042/BCJ20210015

Published: 23 June 2021

View article titled, Evaluation of artificial signal peptides for secretion of two lysosomal enzymes in CHO cells

Includes: Supplementary data

Articles

Structure of plant photosystem I-plastocyanin complex reveals strong hydrophobic interactions

Ido Caspy, Mariia Fadeeva, Sebastian Kuhlgert, Anna Borovikova-Sheinker, Daniel Klaiman, Gal Masrati, Friedel Drepper, Nir Ben-Tal, Michael Hippler, Nathan Nelson

Biochem J (2021) 478 (12): 2371–2384.

DOI: https://doi.org/10.1042/BCJ20210267

Published: 23 June 2021

View article titled, Structure of plant photosystem I-plastocyanin complex reveals strong hydrophobic interactions

Includes: Multimedia, Supplementary data

Articles

Functional role of residues involved in substrate binding of human 4-hydroxyphenylpyruvate dioxygenase

Chih-Wei Huang, Chi-Ching Hwang, Yung-Lung Chang, Jen-Tzu Liu, Sheng-Peng Wu, Kai-Ling Huang, Wei-min Huang, Hwei-Jen Lee

Biochem J (2021) 478 (12): 2201–2215.

DOI: https://doi.org/10.1042/BCJ20210005

Published: 18 June 2021

View article titled, Functional role of residues involved in substrate binding of human 4-hydroxyphenylpyruvate dioxygenase

Includes: Supplementary data

Articles

Current data processing strategies for cryo-electron tomography and subtomogram averaging

In Collection

Awards

Euan Pyle, Giulia Zanetti

Biochem J (2021) 478 (10): 1827–1845.

DOI: https://doi.org/10.1042/BCJ20200715

Published: 18 May 2021

View article titled, Current data processing strategies for cryo-electron tomography and subtomogram averaging

Articles

Classification, structural biology, and applications of mucin domain-targeting proteases

D. Judy Shon, Angel Kuo, Michael J. Ferracane, Stacy A. Malaker

Biochem J (2021) 478 (8): 1585–1603.

DOI: https://doi.org/10.1042/BCJ20200607

Published: 28 April 2021

View article titled, Classification, structural biology, and applications of mucin domain-targeting proteases

Articles

Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response

Hayato Irokawa, Satoshi Numasaki, Shin Kato, Kenta Iwai, Atsushi Inose-Maruyama, Takumi Ohdate, Gi-Wook Hwang, Takashi Toyama, Toshihiko Watanabe, Shusuke Kuge

Biochem J (2021) 478 (7): 1453–1470.

DOI: https://doi.org/10.1042/BCJ20200897

Published: 16 April 2021

View article titled, Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response

Includes: Supplementary data

Articles

Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2

Raghupathi Kummari, Shubhankar Dutta, Shubhangi Patil, Snehal Pandav Mudrale, Kakoli Bose

Biochem J (2021) 478 (6): 1241–1259.

DOI: https://doi.org/10.1042/BCJ20200923

Published: 19 March 2021

View article titled, Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2

Includes: Supplementary data

Articles

Principles and practice of determining metal–protein affinities

Tessa R. Young, Zhiguang Xiao

Biochem J (2021) 478 (5): 1085–1116.

DOI: https://doi.org/10.1042/BCJ20200838

Published: 10 March 2021

View article titled, Principles and practice of determining metal–protein affinities

Articles

Influence of the heme distal pocket on nitrite binding orientation and reactivity in Sperm Whale myoglobin

Wilford Tse, Nathan Whitmore, Myles R. Cheesman, Nicholas J. Watmough

Biochem J (2021) 478 (4): 927–942.

DOI: https://doi.org/10.1042/BCJ20200596

Published: 26 February 2021

View article titled, Influence of the heme distal pocket on nitrite binding orientation and reactivity in Sperm Whale myoglobin

Includes: Supplementary data

Articles

Glycoengineering: scratching the surface

Meg Critcher, Timothy O'Leary, Mia L. Huang

Biochem J (2021) 478 (4): 703–719.

DOI: https://doi.org/10.1042/BCJ20200612

Published: 18 February 2021

View article titled, Glycoengineering: scratching the surface

Articles

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

In Collection

Protein structure and function

Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Sebastian Mathea, Deep Chatterjee, Prosenjit Pal, Pawel Lis, Matthew Taylor, Elena Purlyte, Robert Gourlay, Mark Dorward, Simone Weidlich, Rachel Toth, Nicole K. Polinski, Stefan Knapp, Francesca Tonelli, Dario R. Alessi

Biochem J (2021) 478 (3): 553–578.

DOI: https://doi.org/10.1042/BCJ20200937

Published: 10 February 2021

View article titled, Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

Includes: Supplementary data

Articles

Simultaneous detection of reciprocal interactions between calmodulin, Ca 2+ and molecular targets: a focus on the calmodulin-RyR2 complex

Daniele Dell'Orco

Biochem J (2021) 478 (3): 487–491.

DOI: https://doi.org/10.1042/BCJ20200818

Published: 05 February 2021

View article titled, Simultaneous detection of reciprocal interactions between calmodulin, Ca 2+ and molecular targets: a focus on the calmodulin-RyR2 complex

Articles

2′,7′-dichlorofluorescin-based analysis of Fenton chemistry reveals auto-amplification of probe fluorescence and albumin as catalyst for the detection of hydrogen peroxide

Teresa Gonzalez, Franck Peiretti, Catherine Defoort, Patrick Borel, Roland Govers

Biochem J (2020) 477 (24): 4689–4710.

DOI: https://doi.org/10.1042/BCJ20200602

Published: 18 December 2020

View article titled, 2′,7′-dichlorofluorescin-based analysis of Fenton chemistry reveals auto-amplification of probe fluorescence and albumin as catalyst for the detection of hydrogen peroxide

Includes: Supplementary data

Articles

Fragment-derived modulators of an industrial β-glucosidase

Eleni Makraki, John F. Darby, Marta G. Carneiro, James D. Firth, Alex Heyam, Eiso AB, Peter O'Brien, Gregg Siegal, Roderick E. Hubbard

Biochem J (2020) 477 (22): 4383–4395.

DOI: https://doi.org/10.1042/BCJ20200507

Published: 26 November 2020

View article titled, Fragment-derived modulators of an industrial β-glucosidase

Includes: Supplementary data

Articles

Crystal structure of Leptospira leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells

Shen-Hsing Hsu, Chen-Hsi Chu, Ya-Chung Tian, Ming-Yang Chang, Li-Feng Chou, Yuh-Ju Sun, Chih-Wei Yang

Biochem J (2020) 477 (21): 4313–4326.

DOI: https://doi.org/10.1042/BCJ20200547

Published: 13 November 2020

View article titled, Crystal structure of Leptospira leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells

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