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Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI

In Collection

Mitchell H. Omar, Maryanne Kihiu, Dominic P. Byrne, Kyung-Soon Lee, Tyler M. Lakey, Erik Butcher, Patrick A. Eyers, John D. Scott

Biochem J (2023) 480 (12): 875–890.

https://doi.org/10.1042/BCJ20230183

Published: 22 June 2023

View article titled, Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI

Articles

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

In Collection

Cell signaling in the 21st century

Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook

Biochem J (2023) 480 (9): 587–605.

https://doi.org/10.1042/BCJ20220598

Published: 04 May 2023

View article titled, ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

Includes: Supplementary data

Articles

Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

In Collection

Cell signaling in the 21st century

Dominic P. Byrne, Safal Shrestha, Leonard A. Daly, Vanessa Marensi, Krithika Ramakrishnan, Claire E. Eyers, Natarajan Kannan, Patrick A. Eyers

Biochem J (2023) 480 (2): 141–160.

https://doi.org/10.1042/BCJ20220474

Published: 23 January 2023

View article titled, Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

Includes: Multimedia, Supplementary data

Articles

Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

Dominic P. Byrne, James A. London, Patrick A. Eyers, Edwin A. Yates, Alan Cartmell

Biochem J (2021) 478 (13): 2537–2538.

https://doi.org/10.1042/BCJ-2020-0952_COR

Published: 02 July 2021

View article titled, Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

Articles

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

Dominic P. Byrne, James A. London, Patrick A. Eyers, Edwin A. Yates, Alan Cartmell

Biochem J (2021) 478 (4): 735–748.

https://doi.org/10.1042/BCJ20200952

Published: 18 February 2021

View article titled, Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

Articles

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

Dominic P. Byrne, Christopher J. Clarke, Philip J. Brownridge, Anton Kalyuzhnyy, Simon Perkins, Amy Campbell, David Mason, Andrew R. Jones, Patrick A. Eyers, Claire E. Eyers

Biochem J (2020) 477 (13): 2451–2475.

https://doi.org/10.1042/BCJ20200309

Published: 02 July 2020

View article titled, Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

Includes: Supplementary data

Articles

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

In Collection

Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019

Dominic P. Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2435–2455.

https://doi.org/10.1042/BCJ20180266

Published: 14 August 2018

View article titled, New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

Includes: Supplementary data

Articles

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Dominic P. Byrne, Yong Li, Krithika Ramakrishnan, Igor L. Barsukov, Edwin A. Yates, Claire E. Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H. Drewry, William J. Zuercher, Neil G. Berry, David G. Fernig, Patrick A. Eyers

Biochem J (2018) 475 (15): 2417–2433.

https://doi.org/10.1042/BCJ20180265

Published: 14 August 2018

View article titled, New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Includes: Supplementary data

Articles

Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease

Patrick A. Eyers

Biochem J (2018) 475 (1): 185–189.

https://doi.org/10.1042/BCJ20170870

Published: 05 January 2018

View article titled, Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease

Articles

cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry

Dominic P. Byrne, Matthias Vonderach, Samantha Ferries, Philip J. Brownridge, Claire E. Eyers, Patrick A. Eyers

Biochem J (2016) 473 (19): 3159–3175.

https://doi.org/10.1042/BCJ20160648

Published: 27 September 2016

View article titled, cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry

Includes: Supplementary data

Articles

‘Up with the LRRK’: a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement

Patrick A. Eyers

Biochem J (2016) 473 (18): 2757–2762.

https://doi.org/10.1042/BCJ20160671C

Published: 12 September 2016

View article titled, ‘Up with the LRRK’: a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement

Articles

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Fiona P. Bailey, Dominic P. Byrne, Krishnadev Oruganty, Claire E. Eyers, Christopher J. Novotny, Kevan M. Shokat, Natarajan Kannan, Patrick A. Eyers

Biochem J (2015) 467 (1): 47–62.

https://doi.org/10.1042/BJ20141441

Published: 20 March 2015

View article titled, The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Includes: Supplementary data

Articles

Going for broke: targeting the human cancer pseudokinome

Fiona P. Bailey, Dominic P. Byrne, Daniel McSkimming, Natarajan Kannan, Patrick A. Eyers

Biochem J (2015) 465 (2): 195–211.

https://doi.org/10.1042/BJ20141060

Published: 06 January 2015

View article titled, Going for broke: targeting the human cancer pseudokinome

Articles

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Biochem J (2014) 457 (2): 323–334.

https://doi.org/10.1042/BJ20131174

Published: 20 December 2013

View article titled, A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Includes: Supplementary data

Articles

Phosphoregulation of human Mps1 kinase

Rebecca K. Tyler, Matthew L. H. Chu, Hannah Johnson, Edward A. McKenzie, Simon J. Gaskell, Patrick A. Eyers

Biochem J (2009) 417 (1): 173–184.

https://doi.org/10.1042/BJ20081310

Published: 12 December 2008

View article titled, Phosphoregulation of human Mps1 kinase

Includes: Supplementary data

NARROW

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Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI

ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1

Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease

cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility–mass spectrometry

‘Up with the LRRK’: a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Going for broke: targeting the human cancer pseudokinome

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

Phosphoregulation of human Mps1 kinase

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