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Francesca Tonelli
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Articles

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

Alexia F. Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M. Lange, Melanie Wightman, Alan R. Prescott, Shalini Padmanabhan, Esther Sammler, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2022) 479 (17): 1759–1783.
DOI: https://doi.org/10.1042/BCJ20220161
Published: 06 September 2022
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Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

In Collection
Protein structure and function
Asad U. Malik, Athanasios Karapetsas, Raja S. Nirujogi, Sebastian Mathea, Deep Chatterjee, Prosenjit Pal, Pawel Lis, Matthew Taylor, Elena Purlyte, Robert Gourlay, Mark Dorward, Simone Weidlich, Rachel Toth, Nicole K. Polinski, Stefan Knapp, Francesca Tonelli, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2021) 478 (3): 553–578.
DOI: https://doi.org/10.1042/BCJ20200937
Published: 10 February 2021
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Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

Raja S. Nirujogi, Francesca Tonelli, Matthew Taylor, Pawel Lis, Alexander Zimprich, Esther Sammler, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2021) 478 (2): 299–326.
DOI: https://doi.org/10.1042/BCJ20200930
Published: 22 January 2021
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The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Rafeeq Mir, Francesca Tonelli, Pawel Lis, Thomas Macartney, Nicole K. Polinski, Terina N. Martinez, Meng-Yun Chou, Andrew J.M. Howden, Theresa König, Christoph Hotzy, Ivan Milenkovic, Thomas Brücke, Alexander Zimprich, Esther Sammler, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2018) 475 (11): 1861–1883.
DOI: https://doi.org/10.1042/BCJ20180248
Published: 06 June 2018
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Includes: Supplementary data
Articles

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Pawel Lis, Sophie Burel, Martin Steger, Matthias Mann, Fiona Brown, Federico Diez, Francesca Tonelli, Janice L. Holton, Philip Winglok Ho, Shu-Leong Ho, Meng-Yun Chou, Nicole K. Polinski, Terina N. Martinez, Paul Davies, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2018) 475 (1): 1–22.
DOI: https://doi.org/10.1042/BCJ20170802
Published: 02 January 2018
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Includes: Supplementary data
Articles

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A.S. Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Philip Wing-Lok Ho, Shu-Leong Ho, Alastair D. Reith, Dario R. Alessi
Journal: Biochemical Journal
Biochem J (2016) 473 (17): 2671–2685.
DOI: https://doi.org/10.1042/BCJ20160557
Published: 30 August 2016
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Includes: Supplementary data