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Angela CLERK
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Articles

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses

Jacqueline J.T. Marshall, Joshua J. Cull, Hajed O. Alharbi, May Zaw Thin, Susanna T.E. Cooper, Christopher Barrington, Hannah Vanyai, Thomas Snoeks, Bernard Siow, Alejandro Suáarez-Bonnet, Eleanor Herbert, Daniel J. Stuckey, Angus J.M. Cameron, Fabrice Prin, Andrew C. Cook, Simon L. Priestnall, Sonia Chotani, Owen J. L. Rackham, Daniel N. Meijles, Tim Mohun, Angela Clerk, Peter J. Parker
Journal: Biochemical Journal
Biochem J (2022) 479 (13): 1467–1486.
https://doi.org/10.1042/BCJ20220281
Published: 12 July 2022
View article titled, PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses
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Includes: Multimedia, Supplementary data
Articles

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

Angela Clerk, Daniel N. Meijles, Michelle A. Hardyman, Stephen J. Fuller, Sonia P. Chothani, Joshua J. Cull, Susanna T.E. Cooper, Hajed O. Alharbi, Konstantinos Vanezis, Leanne E. Felkin, Thomais Markou, Samuel J. Leonard, Spencer W. Shaw, Owen J.L. Rackham, Stuart A. Cook, Peter E. Glennon, Mary N. Sheppard, John C. Sembrat, Mauricio Rojas, Charles F. McTiernan, Paul J. Barton, Peter H. Sugden
Journal: Biochemical Journal
Biochem J (2022) 479 (3): 401–424.
https://doi.org/10.1042/BCJ20210615
Published: 11 February 2022
View article titled, Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo
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Includes: Supplementary data
Articles

MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins

Stephen J. Fuller, Nick S. Edmunds, Liam J. McGuffin, Michelle A. Hardyman, Joshua J. Cull, Hajed O. Alharbi, Daniel N. Meijles, Peter H. Sugden, Angela Clerk
Journal: Biochemical Journal
Biochem J (2021) 478 (11): 2121–2143.
https://doi.org/10.1042/BCJ20210003
Published: 11 June 2021
View article titled, MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins
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Includes: Supplementary data
Articles

The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α 1 -adrenergic receptors

Daniel N. Meijles, Stephen J. Fuller, Joshua J. Cull, Hajed O. Alharbi, Susanna T.E. Cooper, Peter H. Sugden, Angela Clerk
Journal: Biochemical Journal
Biochem J (2021) 478 (11): 2059–2079.
https://doi.org/10.1042/BCJ20210144
Published: 08 June 2021
View article titled, The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α 1 -adrenergic receptors
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Includes: Supplementary data
Articles

SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions

Peter H. Sugden, Liam J. McGuffin, Angela Clerk
Journal: Biochemical Journal
Biochem J (2013) 454 (1): 13–30.
https://doi.org/10.1042/BJ20130219
Published: 26 July 2013
View article titled, SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions
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Includes: Multimedia, Supplementary data
Articles

p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G q -protein-coupled receptor stimuli, endothelin-1 and α 1 -adrenergic receptor agonists

Emre Amirak, Stephen J. Fuller, Peter H. Sugden, Angela Clerk
Journal: Biochemical Journal
Biochem J (2013) 450 (2): 351–363.
https://doi.org/10.1042/BJ20121371
Published: 15 February 2013
View article titled, p90 Ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G q -protein-coupled receptor stimuli, endothelin-1 and α 1 -adrenergic receptor agonists
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Includes: Supplementary data
Articles

Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target

Alejandro Giraldo, Oliver P. T. Barrett, Marcus J. Tindall, Stephen J. Fuller, Emre Amirak, Bonhi S. Bhattacharya, Peter H. Sugden, Angela Clerk
Journal: Biochemical Journal
Biochem J (2012) 444 (2): 343–355.
https://doi.org/10.1042/BJ20120125
Published: 11 May 2012
View article titled, Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target
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Includes: Supplementary data
Articles

A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)

Stephen J. Fuller, Liam J. McGuffin, Andrew K. Marshall, Alejandro Giraldo, Sampsa Pikkarainen, Angela Clerk, Peter H. Sugden
Journal: Biochemical Journal
Biochem J (2012) 442 (3): 595–610.
https://doi.org/10.1042/BJ20112000
Published: 24 February 2012
View article titled, A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3)
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Includes: Supplementary data
Articles

Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein

Angela CLERK, Timothy J. KEMP, Joanne G. HARRISON, Anthony J. MULLEN, Paul J.R. BARTON, Peter H. SUGDEN
Journal: Biochemical Journal
Biochem J (2002) 368 (1): 101–110.
https://doi.org/10.1042/bj20021083
Published: 15 November 2002
View article titled, Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein
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Articles

Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes

Angela CLERK, Ashour MICHAEL, Peter H. SUGDEN
Journal: Biochemical Journal
Biochem J (1998) 333 (3): 581–589.
https://doi.org/10.1042/bj3330581
Published: 01 August 1998
View article titled, Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes
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Articles

Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart

Antigone LAZOU, Peter H. SUGDEN, Angela CLERK
Journal: Biochemical Journal
Biochem J (1998) 332 (2): 459–465.
https://doi.org/10.1042/bj3320459
Published: 01 June 1998
View article titled, Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart
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Articles

Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes

Angela CLERK, Peter H. SUGDEN
Journal: Biochemical Journal
Biochem J (1997) 325 (3): 801–810.
https://doi.org/10.1042/bj3250801
Published: 01 August 1997
View article titled, Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes
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Articles

Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogen-activated protein kinase activity by bradykinin in rat ventricular myocytes: dissociation from the hypertrophic response

Angela CLERK, Judith GILLESPIE-BROWN, Stephen J. FULLER, Peter H. SUGDEN
Journal: Biochemical Journal
Biochem J (1996) 317 (1): 109–118.
https://doi.org/10.1042/bj3170109
Published: 01 July 1996
View article titled, Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogen-activated protein kinase activity by bradykinin in rat ventricular myocytes: dissociation from the hypertrophic response
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Articles

Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy

Marie A. BOGOYEVITCH, Monica B. ANDERSSON, Judith GILLESPIE-BROWN, Angela CLERK, Peter E. GLENNON, Stephen J. FULLER, Peter H. SUGDEN
Journal: Biochemical Journal
Biochem J (1996) 314 (1): 115–121.
https://doi.org/10.1042/bj3140115
Published: 15 February 1996
View article titled, Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy
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