Issues

LRR-kinase 2 (LRRK2) is a multi-domain protein with three catalytically inert N-terminal domains (NtDs) and four C-terminal domains, including a kinase and a GTPase domain. In this issue, Störmer and colleagues (pp. 815–833) show that the α3^ROC helix, the Switch II motif in the ROC domain, and the LRR–ROC linker play crucial roles in mediating local and global conformational changes. The cover image shows the α3^ROC Helix of fl-LRRK2^INACT and the α3^ROC Helix in LRRK2^RCKW. The image is courtesy of Susan Taylor.