Issues

In this issue Arora and colleagues (pp. 25–39) show that Plasmodium PfUSP is an essential protease for parasite survival, and its inhibition increases the efficacy of artemisinin-based drugs. Therefore, PfUSP can be targeted to develop novel scaffolds for developing new antimalarials to combat artemisinin resistance. The cover image shows fluorescent microscope images of PfUSP transgenic parasites immuno-stained with anti-HA and anti-BiP antibody at different time points in control and iKD sets. This depicts the effect of down-regulation of PfUSP on development of parasite endoplasmic reticulum. The image is courtesy of Asif Mohmmed.