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In this issue, Chattopadhyay and colleagues (pp. 4027–4043) determine that obesity-induced FetA acts as a master upstream regulator of AT inflammation by regulating MCP-1 and iNOS expression through JNK-cJun-IFNγ-JAK2-STAT1 signalling pathway. The cover image shows Stromal vascular fraction (SVF) isolated from SD, HFD and HFD + FetAKD mice subjected to iNOS, CD11c and Arginase 1 immunoblotting. Image courtesy of Sutapa Mukherjee.
In this Issue
Tunneling nanotubes and related structures: molecular mechanisms of formation and function
Biochem J (2021) 478 (22): 3977–3998.
Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state
Pratiti Bhadra; Scott Dos Santos; Igor Gamayun; Tillman Pick; Clarissa Neumann; Joy Ogbechi; Belinda S. Hall; Richard Zimmermann; Volkhard Helms; Rachel E. Simmonds; Adolfo Cavalié
Biochem J (2021) 478 (22): 4005–4024.
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: involvement of IFNγ-JAK2-STAT1 pathway
Biochem J (2021) 478 (22): 4027–4043.
Expression of Concern
Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole
Biochem J (2021) 478 (22): 4025.