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April 2020
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Glutamine transport across cell membranes is performed by a variety of transporters, including the alanine serine cysteine transporter 2 (ASCT2). The substrate-binding site of ASCT2 was proposed to be specific for small amino acids with neutral side chains, excluding basic substrates such as lysine. In this issue Ndaru and co-workers (pp. 1443–1457) expand the substrate specificity of ASCT2 to include amino acid substrates with positively charged side chains. The image shows the docking pose of L-DAB and L-DAP, from the side view of the ASCT2 homology model in the outward-open conformation.The image was provided by Christof Grewer.
ISSN 0264-6021
EISSN 1470-8728
In this Issue
Commentaries
Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle
Biochem J (2020) 477 (8): 1479–1482.
Review Articles
O-glycan recognition and function in mice and human cancers
Gabrielle E. Cervoni; Jane J. Cheng; Kathryn A. Stackhouse; Jamie Heimburg-Molinaro; Richard D. Cummings
Biochem J (2020) 477 (8): 1541–1564.
Research Articles
Structure-based design of small bicyclic peptide inhibitors of Cripto-1 activity
Emanuela Iaccarino; Luisa Calvanese; Gustavo Untiveros; Lucia Falcigno; Gabriella D'Auria; Debora Latino; Jwala Priyadarsini Sivaccumar; Luigi Strizzi; Menotti Ruvo; Annamaria Sandomenico
Biochem J (2020) 477 (8): 1391–1407.
Interaction of the neutral amino acid transporter ASCT2 with basic amino acids
Biochem J (2020) 477 (8): 1443–1457.
Differential effects of ‘resurrecting' Csp pseudoproteases during Clostridioides difficile spore germination
Biochem J (2020) 477 (8): 1459–1478.
Structure of a tRNA-specific deaminase with compromised deamination activity
Biochem J (2020) 477 (8): 1483–1497.
Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2
Biochem J (2020) 477 (8): 1499–1513.
Inorganic polyphosphate is produced and hydrolyzed in F0F1-ATP synthase of mammalian mitochondria
Biochem J (2020) 477 (8): 1515–1524.
Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine
Matthew J. Byrne; Nazia Nasir; Christine Basmadjian; Chitra Bhatia; Rory F. Cunnison; Katherine H. Carr; Corine Mas-Droux; Sharon Yeoh; Céline Cano; Richard Bayliss
Biochem J (2020) 477 (8): 1525–1539.
Osmotic pressure effects identify dehydration upon cytochrome c–cytochrome c oxidase complex formation contributing to a specific electron pathway formation
Wataru Sato; Seiji Hitaoka; Takeshi Uchida; Kyoko Shinzawa-Itoh; Kazunari Yoshizawa; Shinya Yoshikawa; Koichiro Ishimori
Biochem J (2020) 477 (8): 1565–1578.
