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Volume 432, Issue 1

November 2010

All Issues

Cover Image

Cover Image
Front Matter
Table of Contents
Editorial Board

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Accelerated Publications
Research Articles

Accelerated Publications

Human OGA binds substrates in a conserved peptide recognition groove

Marianne Schimpl; Alexander W. Schüttelkopf; Vladimir S. Borodkin; Daan M. F. van Aalten

Biochem J (2010) 432 (1): 1–12.

Abstract

View Articletitled, Human OGA binds substrates in a conserved peptide recognition groove

Supplementary data

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Research Articles

Prevention of diabetic nephropathy in Ins2^+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ

Balu K. Chacko; Colin Reily; Anup Srivastava; Michelle S. Johnson; Yaozu Ye; Elena Ulasova; Anupam Agarwal; Kurt R. Zinn; Michael P. Murphy; Balaraman Kalyanaraman; Victor Darley-Usmar

Biochem J (2010) 432 (1): 9–19.

Abstract

View Articletitled, Prevention of diabetic nephropathy in Ins2+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ

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High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Paul D. Andrews; Melissa Becroft; Anders Aspegren; Jane Gilmour; Martyn J. James; Scott McRae; Robert Kime; Robert W. Allcock; Achamma Abraham; Zhong Jiang; Raimund Strehl; Joanne C. Mountford; Graeme Milligan; Miles D. Houslay; David R. Adams; Julie A. Frearson

Biochem J (2010) 432 (1): 21–35.

Abstract

View Articletitled, High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Supplementary data

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Lysophosphatidylcholines activate G2A inducing G_αi-1-/G_αq/11- Ca²⁺ flux, G_βγ-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

Samina Y. Khan; Nathan J. D. McLaughlin; Marguerite R. Kelher; Phillip Eckels; Fabia Gamboni-Robertson; Anirban Banerjee; Christopher C. Silliman

Biochem J (2010) 432 (1): 35–45.

Abstract

View Articletitled, Lysophosphatidylcholines activate G2A inducing Gαi-1-/Gαq/11- Ca2+ flux, Gβγ-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

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Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development

Yumi Watanabe; Kosei Takeuchi; Susumu Higa Onaga; Michiko Sato; Mika Tsujita; Manabu Abe; Rie Natsume; Minqi Li; Tatsuya Furuichi; Mika Saeki; Tomomi Izumikawa; Ayumi Hasegawa; Minesuke Yokoyama; Shiro Ikegawa; Kenji Sakimura; Norio Amizuka; Hiroshi Kitagawa; Michihiro Igarashi

Biochem J (2010) 432 (1): 47–55.

Abstract

View Articletitled, Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development

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The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric-binding protein A

Husain K. Khambati; Trevor F. Moraes; Jagroop Singh; Stephen R. Shouldice; Rong-hua Yu; Anthony B. Schryvers

Biochem J (2010) 432 (1): 57–67.

Abstract

View Articletitled, The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric-binding protein A

Supplementary data

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Lipin proteins form homo- and hetero-oligomers

Guang-Hui Liu; Jing Qu; Anne E. Carmack; Hyun Bae Kim; Chang Chen; Hongmei Ren; Andrew J. Morris; Brian N. Finck; Thurl E. Harris

Biochem J (2010) 432 (1): 65–76.

Abstract

View Articletitled, Lipin proteins form homo- and hetero-oligomers

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Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations

Joanne Durgan; Peter J. Parker

Biochem J (2010) 432 (1): 77–87.

Abstract

View Articletitled, Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations

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Site-specific modification of calmodulin Ca²⁺ affinity tunes the skeletal muscle ryanodine receptor activation profile

Jie Jiang; Yubin Zhou; Jin Zou; Yanyi Chen; Priya Patel; Jenny J. Yang; Edward M. Balog

Biochem J (2010) 432 (1): 89–99.

Abstract

View Articletitled, Site-specific modification of calmodulin Ca2+ affinity tunes the skeletal muscle ryanodine receptor activation profile

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Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy

Yuki Abe; Jayesh Gor; Daniel G. Bracewell; Stephen J. Perkins; Paul A. Dalby

Biochem J (2010) 432 (1): 101–114.

Abstract

View Articletitled, Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy

Supplementary data

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The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes

Vita Chien; Jacqueline F. Aitken; Shaoping Zhang; Christina M. Buchanan; Anthony Hickey; Thomas Brittain; Garth J. S. Cooper; Kerry M. Loomes

Biochem J (2010) 432 (1): 113–121.

Abstract

View Articletitled, The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes

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Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

Darius J.R. Lane; Stephen R. Robinson; Hania Czerwinska; Glenda M. Bishop; Alfons Lawen

Biochem J (2010) 432 (1): 123–132.

Abstract

View Articletitled, Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

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Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells

Jennifer Robertson; Sue Lang; Peter A. Lambert; Patricia E. Martin

Biochem J (2010) 432 (1): 133–143.

Abstract

View Articletitled, Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells

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Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake¹

Louay Mardini; Jadwiga Gasiorek; Anna Derjuga; Lucie Carrière; Matthias Schranzhofer; Barry H. Paw; Prem Ponka; Volker Blank

Biochem J (2010) 432 (1): 145–151.

Abstract

View Articletitled, Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake1

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Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Sharon A. Matthews; Maria N. Navarro; Linda V. Sinclair; Elizabeth Emslie; Carmen Feijoo-Carnero; Doreen A. Cantrell

Biochem J (2010) 432 (1): 153–163.

Abstract

View Articletitled, Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

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The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals

René Thierbach; Gunnar Drewes; Markus Fusser; Anja Voigt; Doreen Kuhlow; Urte Blume; Tim J. Schulz; Carina Reiche; Hansruedi Glatt; Bernd Epe; Pablo Steinberg; Michael Ristow

Biochem J (2010) 432 (1): 165–172.

Abstract

View Articletitled, The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals

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Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor

Valentina Arfilli; Domenica Carnicelli; Laura Rocchi; Francesca Ricci; Pasqualepaolo Pagliaro; Pier Luigi Tazzari; Maurizio Brigotti

Biochem J (2010) 432 (1): 173–180.

Abstract

View Articletitled, Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor

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Functional domains of yeast hexokinase 2

Rafael Peláez; Pilar Herrero; Fernando Moreno

Biochem J (2010) 432 (1): 181–190.

Abstract

View Articletitled, Functional domains of yeast hexokinase 2

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Akt inhibitors reduce glucose uptake independently of their effects on Akt

Shi-Xiong Tan; Yvonne Ng; David E. James

Biochem J (2010) 432 (1): 191–198.

Abstract

View Articletitled, Akt inhibitors reduce glucose uptake independently of their effects on Akt

Supplementary data

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MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells

Lu Jiang; Xiqiang Liu; Zujian Chen; Yi Jin; Caroline E. Heidbreder; Antonia Kolokythas; Anxun Wang; Yang Dai; Xiaofeng Zhou

Biochem J (2010) 432 (1): 199–207.

Abstract

View Articletitled, MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells

Supplementary data

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Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

Rebecca J. Bird; George S. Baillie; Stephen J. Yarwood

Biochem J (2010) 432 (1): 207–219.

Abstract

View Articletitled, Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

Supplementary data

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Functional dissection of the N-terminal degron of human thymidylate synthase

Sandra P. Melo; Asami Yoshida; Franklin G. Berger

Biochem J (2010) 432 (1): 217–226.

Abstract

View Articletitled, Functional dissection of the N-terminal degron of human thymidylate synthase

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Accelerated Publications

Human OGA binds substrates in a conserved peptide recognition groove

Research Articles

Prevention of diabetic nephropathy in Ins2^+/−AkitaJ mice by the mitochondria-targeted therapy MitoQ

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

Lysophosphatidylcholines activate G2A inducing G_αi-1-/G_αq/11- Ca²⁺ flux, G_βγ-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs

Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development

The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric-binding protein A

Lipin proteins form homo- and hetero-oligomers

Regulation of the tumour suppressor Fbw7α by PKC-dependent phosphorylation and cancer-associated mutations

Site-specific modification of calmodulin Ca²⁺ affinity tunes the skeletal muscle ryanodine receptor activation profile

Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy

The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes

Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells

Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake¹

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals

Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor

Functional domains of yeast hexokinase 2

Akt inhibitors reduce glucose uptake independently of their effects on Akt

MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

Functional dissection of the N-terminal degron of human thymidylate synthase

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