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Volume 409, Issue 2

January 2008

All Issues

Cover Image

Cover Image
Front Matter
Table of Contents
Editorial Board

ISSN 0264-6021

EISSN 1470-8728

In this Issue

Review articles
Research articles

Review articles

SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

Eric Delpire; Kenneth B. E. Gagnon

Biochem J (2008) 409 (2): 321–331.

Abstract

View Articletitled, SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

Supplementary data

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The histidine phosphatase superfamily: structure and function

Daniel J. Rigden

Biochem J (2008) 409 (2): 333–348.

Abstract

View Articletitled, The histidine phosphatase superfamily: structure and function

Supplementary data

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The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease

Sarah Dunn; Ravinder S. Vohra; Jane E. Murphy; Shervanthi Homer-Vanniasinkam; John H. Walker; Sreenivasan Ponnambalam

Biochem J (2008) 409 (2): 349–355.

Abstract

View Articletitled, The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease

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Research articles

The role of loop and β-turn residues as structural and functional determinants for the lipoyl domain from the Escherichia coli 2-oxoglutarate dehydrogenase complex

D. Dafydd Jones; Richard N. Perham

Biochem J (2008) 409 (2): 357–366.

Abstract

View Articletitled, The role of loop and β-turn residues as structural and functional determinants for the lipoyl domain from the Escherichia coli 2-oxoglutarate dehydrogenase complex

Supplementary data

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The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2

Tim J. Fitzmaurice; David F. Burke; Lee Hopkins; Sujeong Yang; Shuiliang Yu; Man-Sun Sy; Alana M. Thackray; Raymond Bujdoso

Biochem J (2008) 409 (2): 367–375.

Abstract

View Articletitled, The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2

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Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space

Felicity H. Alcock; J. Günter Grossmann; Ian E. Gentle; Vladimir A. Likić; Trevor Lithgow; Kostas Tokatlidis

Biochem J (2008) 409 (2): 377–387.

Abstract

View Articletitled, Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space

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Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1

Tongtong Zou; Lan Liu; Jaladanki N. Rao; Bernard S. Marasa; Jie Chen; Lan Xiao; Huiping Zhou; Myriam Gorospe; Jian-Ying Wang

Biochem J (2008) 409 (2): 389–398.

Abstract

View Articletitled, Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1

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A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae

Tomokazu Ito; Hisashi Hemmi; Kunishige Kataoka; Yukio Mukai; Tohru Yoshimura

Biochem J (2008) 409 (2): 399–406.

Abstract

View Articletitled, A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae

Supplementary data

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A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3

Margaret E. Graham; Mark T. W. Handley; Jeff W. Barclay; Leo F. Ciufo; Stephanie L. Barrow; Alan Morgan; Robert D. Burgoyne

Biochem J (2008) 409 (2): 407–416.

Abstract

View Articletitled, A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3

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Insights into the structural basis of the pH-dependent dimer–tetramer equilibrium through crystallographic analysis of recombinant Diocleinae lectins

Celso S. Nagano; Juan J. Calvete; Domingo Barettino; Alicia Pérez; Benildo S. Cavada; Libia Sanz

Biochem J (2008) 409 (2): 417–428.

Abstract

View Articletitled, Insights into the structural basis of the pH-dependent dimer–tetramer equilibrium through crystallographic analysis of recombinant Diocleinae lectins

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Human group III secreted phospholipase A₂ promotes neuronal outgrowth and survival

Seiko Masuda; Kei Yamamoto; Tetsuya Hirabayashi; Yukio Ishikawa; Toshiharu Ishii; Ichiro Kudo; Makoto Murakami

Biochem J (2008) 409 (2): 429–438.

Abstract

View Articletitled, Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival

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Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy

Lakshmi D. Devanur; Robert W. Evans; Patricia J. Evans; Robert C. Hider

Biochem J (2008) 409 (2): 439–447.

Abstract

View Articletitled, Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy

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Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Shuai Chen; Jane Murphy; Rachel Toth; David G. Campbell; Nick A. Morrice; Carol Mackintosh

Biochem J (2008) 409 (2): 449–459.

Abstract

View Articletitled, Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Supplementary data

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Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family

Marcin Drag; Jowita Mikolajczyk; I. M. Krishnakumar; Ziwei Huang; Guy S. Salvesen

Biochem J (2008) 409 (2): 461–469.

Abstract

View Articletitled, Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family

Supplementary data

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Regulation of clathrin-dependent endocytosis by diacylglycerol kinase δ: importance of kinase activity and binding to AP2α

Takumi Kawasaki; Takeshi Kobayashi; Takehiko Ueyama; Yasuhito Shirai; Naoaki Saito

Biochem J (2008) 409 (2): 471–479.

Abstract

View Articletitled, Regulation of clathrin-dependent endocytosis by diacylglycerol kinase δ: importance of kinase activity and binding to AP2α

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Amino acids 39–456 of the large subunit and 210–262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania

Somdeb Bosedasgupta; Benu Brata Das; Souvik Sengupta; Agneyo Ganguly; Amit Roy; Gayatri Tripathi; Hemanta K. Majumder

Biochem J (2008) 409 (2): 481–489.

Abstract

View Articletitled, Amino acids 39–456 of the large subunit and 210–262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania

Supplementary data

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High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

Florian L. Muller; Yuhong Liu; Muhammad A. Abdul-Ghani; Michael S. Lustgarten; Arunabh Bhattacharya; Youngmok C. Jang; Holly Van Remmen

Biochem J (2008) 409 (2): 491–499.

Abstract

View Articletitled, High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

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Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIβ

Gwanghyun Jung; Jing Wang; Pawel Wlodarski; Barbara Barylko; Derk D. Binns; Hongjun Shu; Helen L. Yin; Joseph P. Albanesi

Biochem J (2008) 409 (2): 501–509.

Abstract

View Articletitled, Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIβ

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A conserved mechanism for replication origin recognition and binding in archaea

Alan I. Majerník; James P. J. Chong

Biochem J (2008) 409 (2): 511–518.

Abstract

View Articletitled, A conserved mechanism for replication origin recognition and binding in archaea

Supplementary data

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Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

Jeffrey D. Carson; Glenn Van Aller; Ruth Lehr; Robert H. Sinnamon; Robert B. Kirkpatrick; Kurt R. Auger; Dashyant Dhanak; Robert A. Copeland; Richard R. Gontarek; Peter J. Tummino; Lusong Luo

Biochem J (2008) 409 (2): 519–524.

Abstract

View Articletitled, Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

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Function of the N-terminus of zizimin1: autoinhibition and membrane targeting

Nahum Meller; M. Jody Westbrook; John D. Shannon; Chittibabu Guda; Martin A. Schwartz

Biochem J (2008) 409 (2): 525–533.

Abstract

View Articletitled, Function of the N-terminus of zizimin1: autoinhibition and membrane targeting

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Complementary roles of SufA and IscA in the biogenesis of iron–sulfur clusters in Escherichia coli

Jianxin Lu; Juanjuan Yang; Guoqiang Tan; Huangen Ding

Biochem J (2008) 409 (2): 535–543.

Abstract

View Articletitled, Complementary roles of SufA and IscA in the biogenesis of iron–sulfur clusters in Escherichia coli

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Trimerization of collagen IX α-chains does not require the presence of the COL1 and NC1 domains

Juha Jäälinoja; Joni Ylöstalo; William Beckett; David J. S. Hulmes; Leena Ala-Kokko

Biochem J (2008) 409 (2): 545–554.

Abstract

View Articletitled, Trimerization of collagen IX α-chains does not require the presence of the COL1 and NC1 domains

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Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane

Satoshi Takida; Yusuke Maeda; Taroh Kinoshita

Biochem J (2008) 409 (2): 555–562.

Abstract

View Articletitled, Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane

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Validation of spermidine synthase as a drug target in African trypanosomes

Martin C. Taylor; Harparkash Kaur; Bernard Blessington; John M. Kelly; Shane R. Wilkinson

Biochem J (2008) 409 (2): 563–569.

Abstract

View Articletitled, Validation of spermidine synthase as a drug target in African trypanosomes

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Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum α-glucosidase inhibition

Dominic S. Alonzi; David C. A. Neville; Robin H. Lachmann; Raymond A. Dwek; Terry D. Butters

Biochem J (2008) 409 (2): 571–580.

Abstract

View Articletitled, Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum α-glucosidase inhibition

Supplementary data

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Nagma Khan; Michael Jeffers; Sampath Kumar; Craig Hackett; Ferenc Boldog; Nicholai Khramtsov; Xiaozhong Qian; Evan Mills; Stanny C. Berghs; Nessa Carey; Paul W. Finn; Laura S. Collins; Anthony Tumber; James W. Ritchie; Peter Buhl Jensen; Henri S. Lichenstein; Maxwell Sehested

Biochem J (2008) 409 (2): 581–589.

Abstract

View Articletitled, Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Supplementary data

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Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals

Herbert Kaltner; Dolores Solís; Jürgen Kopitz; Martin Lensch; Michaela Lohr; Joachim C. Manning; Michael Mürnseer; Martina Schnölzer; Sabine André; José Luis Sáiz; Hans-Joachim Gabius

Biochem J (2008) 409 (2): 591–599.

Abstract

View Articletitled, Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals

Supplementary data

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Novel molecules for intra-oral delivery of antimicrobials to prevent and treat oral infectious diseases

Periathamby Antony Raj; Latha Rajkumar; Andrew R. Dentino

Biochem J (2008) 409 (2): 601–609.

Abstract

View Articletitled, Novel molecules for intra-oral delivery of antimicrobials to prevent and treat oral infectious diseases

Supplementary data

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An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3′-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme

Amit Roy; Benu Brata Das; Agneyo Ganguly; Somdeb Bose Dasgupta; Neeta V. M. Khalkho; Churala Pal; Sumit Dey; Venkatachalam Sesha Giri; Parasuraman Jaisankar; Sanjit Dey; Hemanta K. Majumder

Biochem J (2008) 409 (2): 611–622.

Abstract

View Articletitled, An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3′-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme

Supplementary data

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Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

Activin E is a transforming growth factor β ligand that signals specifically through activin receptor-like kinase 7

Correction: Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition

Expression of Concern: Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway

Review articles

SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

The histidine phosphatase superfamily: structure and function

The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease

Research articles

The role of loop and β-turn residues as structural and functional determinants for the lipoyl domain from the Escherichia coli 2-oxoglutarate dehydrogenase complex

The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2

Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space

Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1

A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3

Insights into the structural basis of the pH-dependent dimer–tetramer equilibrium through crystallographic analysis of recombinant Diocleinae lectins

Human group III secreted phospholipase A₂ promotes neuronal outgrowth and survival

Chelator-facilitated removal of iron from transferrin: relevance to combined chelation therapy

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family

Regulation of clathrin-dependent endocytosis by diacylglycerol kinase δ: importance of kinase activity and binding to AP2α

Amino acids 39–456 of the large subunit and 210–262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania

High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates

Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIβ

A conserved mechanism for replication origin recognition and binding in archaea

Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

Function of the N-terminus of zizimin1: autoinhibition and membrane targeting

Complementary roles of SufA and IscA in the biogenesis of iron–sulfur clusters in Escherichia coli

Trimerization of collagen IX α-chains does not require the presence of the COL1 and NC1 domains

Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane

Validation of spermidine synthase as a drug target in African trypanosomes

Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum α-glucosidase inhibition

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Prototype chicken galectins revisited: characterization of a third protein with distinctive hydrodynamic behaviour and expression pattern in organs of adult animals

Novel molecules for intra-oral delivery of antimicrobials to prevent and treat oral infectious diseases

An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3′-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme

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